Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2

Agrimonia pilosa (AP), Galla rhois (RG), and their mixture (APRG64) strongly inhibited SARS-CoV-2 by interfering with multiple steps of the viral life cycle including viral entry and replication. Furthermore, among 12 components identified in APRG64, three displayed strong antiviral activity, ursoli...

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Autores principales: Lee, Yeong-Geun, Kang, Kyung Won, Hong, Woojae, Kim, Yeon Hwa, Oh, Jen Taek, Park, Dae Won, Ko, Minsung, Bai, Yun-Feng, Seo, Young-Jin, Lee, Sang-Myeong, Kim, Hyunggun, Kang, Se Chan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299292/
https://www.ncbi.nlm.nih.gov/pubmed/34329818
http://dx.doi.org/10.1016/j.bmc.2021.116329
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author Lee, Yeong-Geun
Kang, Kyung Won
Hong, Woojae
Kim, Yeon Hwa
Oh, Jen Taek
Park, Dae Won
Ko, Minsung
Bai, Yun-Feng
Seo, Young-Jin
Lee, Sang-Myeong
Kim, Hyunggun
Kang, Se Chan
author_facet Lee, Yeong-Geun
Kang, Kyung Won
Hong, Woojae
Kim, Yeon Hwa
Oh, Jen Taek
Park, Dae Won
Ko, Minsung
Bai, Yun-Feng
Seo, Young-Jin
Lee, Sang-Myeong
Kim, Hyunggun
Kang, Se Chan
author_sort Lee, Yeong-Geun
collection PubMed
description Agrimonia pilosa (AP), Galla rhois (RG), and their mixture (APRG64) strongly inhibited SARS-CoV-2 by interfering with multiple steps of the viral life cycle including viral entry and replication. Furthermore, among 12 components identified in APRG64, three displayed strong antiviral activity, ursolic acid (1), quercetin (7), and 1,2,3,4,6-penta-O-galloyl-β-d-glucose (12). Molecular docking analysis showed these components to bind potently to the spike receptor-binding-domain (RBD) of the SARS-CoV-2 and its variant B.1.1.7. Taken together, these findings indicate APRG64 as a potent drug candidate to treat SARS-CoV-2 and its variants.
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spelling pubmed-82992922021-07-23 Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2 Lee, Yeong-Geun Kang, Kyung Won Hong, Woojae Kim, Yeon Hwa Oh, Jen Taek Park, Dae Won Ko, Minsung Bai, Yun-Feng Seo, Young-Jin Lee, Sang-Myeong Kim, Hyunggun Kang, Se Chan Bioorg Med Chem Article Agrimonia pilosa (AP), Galla rhois (RG), and their mixture (APRG64) strongly inhibited SARS-CoV-2 by interfering with multiple steps of the viral life cycle including viral entry and replication. Furthermore, among 12 components identified in APRG64, three displayed strong antiviral activity, ursolic acid (1), quercetin (7), and 1,2,3,4,6-penta-O-galloyl-β-d-glucose (12). Molecular docking analysis showed these components to bind potently to the spike receptor-binding-domain (RBD) of the SARS-CoV-2 and its variant B.1.1.7. Taken together, these findings indicate APRG64 as a potent drug candidate to treat SARS-CoV-2 and its variants. Elsevier Ltd. 2021-09-01 2021-07-23 /pmc/articles/PMC8299292/ /pubmed/34329818 http://dx.doi.org/10.1016/j.bmc.2021.116329 Text en © 2021 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Lee, Yeong-Geun
Kang, Kyung Won
Hong, Woojae
Kim, Yeon Hwa
Oh, Jen Taek
Park, Dae Won
Ko, Minsung
Bai, Yun-Feng
Seo, Young-Jin
Lee, Sang-Myeong
Kim, Hyunggun
Kang, Se Chan
Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2
title Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2
title_full Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2
title_fullStr Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2
title_full_unstemmed Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2
title_short Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2
title_sort potent antiviral activity of agrimonia pilosa, galla rhois, and their components against sars-cov-2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299292/
https://www.ncbi.nlm.nih.gov/pubmed/34329818
http://dx.doi.org/10.1016/j.bmc.2021.116329
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