The conditional growth suppressor E7.25d.7 is an allele of the sterile-20 kinase misshapen

The notion of a two-hit or multi-hit model of carcinogenesis dates to at least the 1970’s and work done by Alfred Knudson. This concept was considered in the design and execution of a previous FLP/FRT screen in Drosophila melanogaster for conditional growth suppressors. During the course of this wor...

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Detalles Bibliográficos
Autores principales: Kiely, Evan, Gilbert-Ross, Melissa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2021
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299297/
https://www.ncbi.nlm.nih.gov/pubmed/34316546
http://dx.doi.org/10.17912/micropub.biology.000424
Descripción
Sumario:The notion of a two-hit or multi-hit model of carcinogenesis dates to at least the 1970’s and work done by Alfred Knudson. This concept was considered in the design and execution of a previous FLP/FRT screen in Drosophila melanogaster for conditional growth suppressors. During the course of this work, the lethal allele E7.25D.7 was identified as being of phenotypic interest. Here we report the genetic mapping of E7.25D.7, an allele of the sterile-20 kinase misshapen (msn).

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