The conditional growth suppressor E7.25d.7 is an allele of the sterile-20 kinase misshapen

The notion of a two-hit or multi-hit model of carcinogenesis dates to at least the 1970’s and work done by Alfred Knudson. This concept was considered in the design and execution of a previous FLP/FRT screen in Drosophila melanogaster for conditional growth suppressors. During the course of this wor...

Descripción completa

Detalles Bibliográficos
Autores principales: Kiely, Evan, Gilbert-Ross, Melissa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2021
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299297/
https://www.ncbi.nlm.nih.gov/pubmed/34316546
http://dx.doi.org/10.17912/micropub.biology.000424
_version_ 1783726242189541376
author Kiely, Evan
Gilbert-Ross, Melissa
author_facet Kiely, Evan
Gilbert-Ross, Melissa
author_sort Kiely, Evan
collection PubMed
description The notion of a two-hit or multi-hit model of carcinogenesis dates to at least the 1970’s and work done by Alfred Knudson. This concept was considered in the design and execution of a previous FLP/FRT screen in Drosophila melanogaster for conditional growth suppressors. During the course of this work, the lethal allele E7.25D.7 was identified as being of phenotypic interest. Here we report the genetic mapping of E7.25D.7, an allele of the sterile-20 kinase misshapen (msn).
format Online
Article
Text
id pubmed-8299297
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Caltech Library
record_format MEDLINE/PubMed
spelling pubmed-82992972021-07-26 The conditional growth suppressor E7.25d.7 is an allele of the sterile-20 kinase misshapen Kiely, Evan Gilbert-Ross, Melissa MicroPubl Biol New Finding The notion of a two-hit or multi-hit model of carcinogenesis dates to at least the 1970’s and work done by Alfred Knudson. This concept was considered in the design and execution of a previous FLP/FRT screen in Drosophila melanogaster for conditional growth suppressors. During the course of this work, the lethal allele E7.25D.7 was identified as being of phenotypic interest. Here we report the genetic mapping of E7.25D.7, an allele of the sterile-20 kinase misshapen (msn). Caltech Library 2021-07-22 /pmc/articles/PMC8299297/ /pubmed/34316546 http://dx.doi.org/10.17912/micropub.biology.000424 Text en Copyright: © 2021 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Kiely, Evan
Gilbert-Ross, Melissa
The conditional growth suppressor E7.25d.7 is an allele of the sterile-20 kinase misshapen
title The conditional growth suppressor E7.25d.7 is an allele of the sterile-20 kinase misshapen
title_full The conditional growth suppressor E7.25d.7 is an allele of the sterile-20 kinase misshapen
title_fullStr The conditional growth suppressor E7.25d.7 is an allele of the sterile-20 kinase misshapen
title_full_unstemmed The conditional growth suppressor E7.25d.7 is an allele of the sterile-20 kinase misshapen
title_short The conditional growth suppressor E7.25d.7 is an allele of the sterile-20 kinase misshapen
title_sort conditional growth suppressor e7.25d.7 is an allele of the sterile-20 kinase misshapen
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299297/
https://www.ncbi.nlm.nih.gov/pubmed/34316546
http://dx.doi.org/10.17912/micropub.biology.000424
work_keys_str_mv AT kielyevan theconditionalgrowthsuppressore725d7isanalleleofthesterile20kinasemisshapen
AT gilbertrossmelissa theconditionalgrowthsuppressore725d7isanalleleofthesterile20kinasemisshapen
AT kielyevan conditionalgrowthsuppressore725d7isanalleleofthesterile20kinasemisshapen
AT gilbertrossmelissa conditionalgrowthsuppressore725d7isanalleleofthesterile20kinasemisshapen

Ejemplares similares