Chronic Myeloid Leukemia in a Patient with Hepatitis B Virus Infection: A Case Report

Chronic myeloid leukemia (CML) is a myeloproliferative disorder diagnosed by demonstrating the Philadelphia chromosome (Ph) or the BCR-ABL fusion gene. Tyrosine kinase inhibitors (TKIs) are the standard of therapy. There are increasing reports of hepatitis B virus reactivation (HBVr) in patients on...

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Autores principales: Ali Hailan, Yousef Mohammed, Mudawi, Deena, Yassin, Mohamed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299369/
https://www.ncbi.nlm.nih.gov/pubmed/34326735
http://dx.doi.org/10.1159/000516747
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author Ali Hailan, Yousef Mohammed
Mudawi, Deena
Yassin, Mohamed A.
author_facet Ali Hailan, Yousef Mohammed
Mudawi, Deena
Yassin, Mohamed A.
author_sort Ali Hailan, Yousef Mohammed
collection PubMed
description Chronic myeloid leukemia (CML) is a myeloproliferative disorder diagnosed by demonstrating the Philadelphia chromosome (Ph) or the BCR-ABL fusion gene. Tyrosine kinase inhibitors (TKIs) are the standard of therapy. There are increasing reports of hepatitis B virus reactivation (HBVr) in patients on this treatment. We report a case of a 46-year-old male patient diagnosed to have CML in the chronic phase and resolved hepatitis B infection. He was treated with imatinib as upfront therapy for CML and with lamivudine as prophylaxis against HBVr. The patient tolerated both treatments well with no adverse effects. The aim is to address the deficiencies in the literature in regard to managing these patients, prevention, and follow-up.
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spelling pubmed-82993692021-07-28 Chronic Myeloid Leukemia in a Patient with Hepatitis B Virus Infection: A Case Report Ali Hailan, Yousef Mohammed Mudawi, Deena Yassin, Mohamed A. Case Rep Oncol Case Report Chronic myeloid leukemia (CML) is a myeloproliferative disorder diagnosed by demonstrating the Philadelphia chromosome (Ph) or the BCR-ABL fusion gene. Tyrosine kinase inhibitors (TKIs) are the standard of therapy. There are increasing reports of hepatitis B virus reactivation (HBVr) in patients on this treatment. We report a case of a 46-year-old male patient diagnosed to have CML in the chronic phase and resolved hepatitis B infection. He was treated with imatinib as upfront therapy for CML and with lamivudine as prophylaxis against HBVr. The patient tolerated both treatments well with no adverse effects. The aim is to address the deficiencies in the literature in regard to managing these patients, prevention, and follow-up. S. Karger AG 2021-06-24 /pmc/articles/PMC8299369/ /pubmed/34326735 http://dx.doi.org/10.1159/000516747 Text en Copyright © 2021 by S. Karger AG, Basel https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC). Usage and distribution for commercial purposes requires written permission. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
spellingShingle Case Report
Ali Hailan, Yousef Mohammed
Mudawi, Deena
Yassin, Mohamed A.
Chronic Myeloid Leukemia in a Patient with Hepatitis B Virus Infection: A Case Report
title Chronic Myeloid Leukemia in a Patient with Hepatitis B Virus Infection: A Case Report
title_full Chronic Myeloid Leukemia in a Patient with Hepatitis B Virus Infection: A Case Report
title_fullStr Chronic Myeloid Leukemia in a Patient with Hepatitis B Virus Infection: A Case Report
title_full_unstemmed Chronic Myeloid Leukemia in a Patient with Hepatitis B Virus Infection: A Case Report
title_short Chronic Myeloid Leukemia in a Patient with Hepatitis B Virus Infection: A Case Report
title_sort chronic myeloid leukemia in a patient with hepatitis b virus infection: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299369/
https://www.ncbi.nlm.nih.gov/pubmed/34326735
http://dx.doi.org/10.1159/000516747
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AT mudawideena chronicmyeloidleukemiainapatientwithhepatitisbvirusinfectionacasereport
AT yassinmohameda chronicmyeloidleukemiainapatientwithhepatitisbvirusinfectionacasereport

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