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Acute kidney injury with partial Fanconi syndrome in a patient with leptospirosis: a case report

BACKGROUND: Leptospirosis is an underdiagnosed bacterial infection with nonspecific symptoms, hence, a diagnostic challenge. Identifying a case of leptospirosis in Switzerland is uncommon. Although kidney complications are frequent in severe forms, including tubular dysfunction, observing this compl...

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Autores principales: Weiner, Marc, Coen, Matteo, Serratrice, Jacques, Mavrakanas, Thomas A., Leidi, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299617/
https://www.ncbi.nlm.nih.gov/pubmed/34294111
http://dx.doi.org/10.1186/s13256-021-02978-0
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author Weiner, Marc
Coen, Matteo
Serratrice, Jacques
Mavrakanas, Thomas A.
Leidi, Antonio
author_facet Weiner, Marc
Coen, Matteo
Serratrice, Jacques
Mavrakanas, Thomas A.
Leidi, Antonio
author_sort Weiner, Marc
collection PubMed
description BACKGROUND: Leptospirosis is an underdiagnosed bacterial infection with nonspecific symptoms, hence, a diagnostic challenge. Identifying a case of leptospirosis in Switzerland is uncommon. Although kidney complications are frequent in severe forms, including tubular dysfunction, observing this complication is rare in our country. We report the case of a patient with leptospirosis and kidney dysfunction, which was notable for proximal tubulopathy. This case report describes the diagnosis and management of this patient’s tubular dysfunction. CASE PRESENTATION: A 34-year-old Caucasian male known for alcohol and drug abuse presented to our emergency department suffering from severe pain in the lower limbs, jaundice, and fever with flu-like symptoms. Physical examination was not contributory. Blood tests showed cytopenia, elevated inflammatory markers, acute kidney injury, and altered liver function tests with predominant cholestasis. Urinalysis showed proteinuria and significant glycosuria without concomitant hyperglycemia. Leptospirosis was suspected and confirmed by both positive serum polymerase chain reaction and elevated immunoglobulin M for Leptospira interrogans. The patient was treated with intravenous amoxicillin–clavulanate and doxycycline for 7 days. After antibiotic treatment, symptoms disappeared, and kidney dysfunction completely resolved. CONCLUSION: Our case focuses on the description of leptospirosis-related acute kidney injury with proximal tubular dysfunction, which is a rare finding in Switzerland.
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spelling pubmed-82996172021-07-28 Acute kidney injury with partial Fanconi syndrome in a patient with leptospirosis: a case report Weiner, Marc Coen, Matteo Serratrice, Jacques Mavrakanas, Thomas A. Leidi, Antonio J Med Case Rep Case Report BACKGROUND: Leptospirosis is an underdiagnosed bacterial infection with nonspecific symptoms, hence, a diagnostic challenge. Identifying a case of leptospirosis in Switzerland is uncommon. Although kidney complications are frequent in severe forms, including tubular dysfunction, observing this complication is rare in our country. We report the case of a patient with leptospirosis and kidney dysfunction, which was notable for proximal tubulopathy. This case report describes the diagnosis and management of this patient’s tubular dysfunction. CASE PRESENTATION: A 34-year-old Caucasian male known for alcohol and drug abuse presented to our emergency department suffering from severe pain in the lower limbs, jaundice, and fever with flu-like symptoms. Physical examination was not contributory. Blood tests showed cytopenia, elevated inflammatory markers, acute kidney injury, and altered liver function tests with predominant cholestasis. Urinalysis showed proteinuria and significant glycosuria without concomitant hyperglycemia. Leptospirosis was suspected and confirmed by both positive serum polymerase chain reaction and elevated immunoglobulin M for Leptospira interrogans. The patient was treated with intravenous amoxicillin–clavulanate and doxycycline for 7 days. After antibiotic treatment, symptoms disappeared, and kidney dysfunction completely resolved. CONCLUSION: Our case focuses on the description of leptospirosis-related acute kidney injury with proximal tubular dysfunction, which is a rare finding in Switzerland. BioMed Central 2021-07-23 /pmc/articles/PMC8299617/ /pubmed/34294111 http://dx.doi.org/10.1186/s13256-021-02978-0 Text en © The Author(s) 2021, corrected publication 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Weiner, Marc
Coen, Matteo
Serratrice, Jacques
Mavrakanas, Thomas A.
Leidi, Antonio
Acute kidney injury with partial Fanconi syndrome in a patient with leptospirosis: a case report
title Acute kidney injury with partial Fanconi syndrome in a patient with leptospirosis: a case report
title_full Acute kidney injury with partial Fanconi syndrome in a patient with leptospirosis: a case report
title_fullStr Acute kidney injury with partial Fanconi syndrome in a patient with leptospirosis: a case report
title_full_unstemmed Acute kidney injury with partial Fanconi syndrome in a patient with leptospirosis: a case report
title_short Acute kidney injury with partial Fanconi syndrome in a patient with leptospirosis: a case report
title_sort acute kidney injury with partial fanconi syndrome in a patient with leptospirosis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299617/
https://www.ncbi.nlm.nih.gov/pubmed/34294111
http://dx.doi.org/10.1186/s13256-021-02978-0
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