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Access to systemic anti-cancer therapies for women with secondary breast cancer—protocol for a mixed methods systematic review
BACKGROUND: It is well recognised that access and receipt of appropriate guideline recommended treatment with systemic anti-cancer therapies for secondary breast cancer is a key determinant in overall survival. Where there is disparity in access this may result in unwarranted variation and disparity...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299679/ https://www.ncbi.nlm.nih.gov/pubmed/34294151 http://dx.doi.org/10.1186/s13643-021-01761-y |
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author | Pearson, Sally Anne Taylor, Sally Marsden, Antonia Yorke, Janelle |
author_facet | Pearson, Sally Anne Taylor, Sally Marsden, Antonia Yorke, Janelle |
author_sort | Pearson, Sally Anne |
collection | PubMed |
description | BACKGROUND: It is well recognised that access and receipt of appropriate guideline recommended treatment with systemic anti-cancer therapies for secondary breast cancer is a key determinant in overall survival. Where there is disparity in access this may result in unwarranted variation and disparity in outcomes. Individual, clinical and wider contextual factors have been associated with these disparities, however this remains poorly understood for women with secondary breast cancer. The purpose of the review is to examine individual, clinical and contextual factors which influence access to evidence-based systemic anti-cancer therapies for women with secondary breast cancer. This will include barriers and facilitators for access and receipt of treatment and an exploration of women and clinicians experience and perspectives on access. METHODS: A mixed methods approach with a segregated design will be used to examine and explore factors which influence access to systemic anti-cancer therapies for women with secondary breast cancer. Electronic databases to be searched from January 2000 onwards will be EBSCO CINAHL Plus, Ovid MEDLINE, Ovid EMBASE, PsychINFO and the Cochrane Library and JBI database. This will include NHS Evidence which will be searched for unpublished studies and gray literature. Title and abstract citations and full-text articles will be screened by the author and second reviewer. Data will be extracted by the author and validated by the second reviewer. An overarching synthesis will be produced which brings together quantitative and qualitative findings. Methodological quality and risk of bias will be assessed using the Mixed Methods Appraisal Tool. DISCUSSION: Understanding individual, clinical and wider contextual factors associated with access and receipt of systemic anti-cancer therapies for secondary breast cancer is a complex phenomenon. These will be examined to determine any association with access. Review findings will be used to guide future research in this area and the development of an evidence-based service level intervention designed to address unwarranted variation in access based upon the Medical Research Council (MRC) approach to the development, implementation and evaluation of complex interventions. SYSTEMATIC REVIEW REGISTRATION: The review protocol has been registered in PROSPERO CRD42020196490. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13643-021-01761-y. |
format | Online Article Text |
id | pubmed-8299679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-82996792021-07-28 Access to systemic anti-cancer therapies for women with secondary breast cancer—protocol for a mixed methods systematic review Pearson, Sally Anne Taylor, Sally Marsden, Antonia Yorke, Janelle Syst Rev Protocol BACKGROUND: It is well recognised that access and receipt of appropriate guideline recommended treatment with systemic anti-cancer therapies for secondary breast cancer is a key determinant in overall survival. Where there is disparity in access this may result in unwarranted variation and disparity in outcomes. Individual, clinical and wider contextual factors have been associated with these disparities, however this remains poorly understood for women with secondary breast cancer. The purpose of the review is to examine individual, clinical and contextual factors which influence access to evidence-based systemic anti-cancer therapies for women with secondary breast cancer. This will include barriers and facilitators for access and receipt of treatment and an exploration of women and clinicians experience and perspectives on access. METHODS: A mixed methods approach with a segregated design will be used to examine and explore factors which influence access to systemic anti-cancer therapies for women with secondary breast cancer. Electronic databases to be searched from January 2000 onwards will be EBSCO CINAHL Plus, Ovid MEDLINE, Ovid EMBASE, PsychINFO and the Cochrane Library and JBI database. This will include NHS Evidence which will be searched for unpublished studies and gray literature. Title and abstract citations and full-text articles will be screened by the author and second reviewer. Data will be extracted by the author and validated by the second reviewer. An overarching synthesis will be produced which brings together quantitative and qualitative findings. Methodological quality and risk of bias will be assessed using the Mixed Methods Appraisal Tool. DISCUSSION: Understanding individual, clinical and wider contextual factors associated with access and receipt of systemic anti-cancer therapies for secondary breast cancer is a complex phenomenon. These will be examined to determine any association with access. Review findings will be used to guide future research in this area and the development of an evidence-based service level intervention designed to address unwarranted variation in access based upon the Medical Research Council (MRC) approach to the development, implementation and evaluation of complex interventions. SYSTEMATIC REVIEW REGISTRATION: The review protocol has been registered in PROSPERO CRD42020196490. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13643-021-01761-y. BioMed Central 2021-07-23 /pmc/articles/PMC8299679/ /pubmed/34294151 http://dx.doi.org/10.1186/s13643-021-01761-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Protocol Pearson, Sally Anne Taylor, Sally Marsden, Antonia Yorke, Janelle Access to systemic anti-cancer therapies for women with secondary breast cancer—protocol for a mixed methods systematic review |
title | Access to systemic anti-cancer therapies for women with secondary breast cancer—protocol for a mixed methods systematic review |
title_full | Access to systemic anti-cancer therapies for women with secondary breast cancer—protocol for a mixed methods systematic review |
title_fullStr | Access to systemic anti-cancer therapies for women with secondary breast cancer—protocol for a mixed methods systematic review |
title_full_unstemmed | Access to systemic anti-cancer therapies for women with secondary breast cancer—protocol for a mixed methods systematic review |
title_short | Access to systemic anti-cancer therapies for women with secondary breast cancer—protocol for a mixed methods systematic review |
title_sort | access to systemic anti-cancer therapies for women with secondary breast cancer—protocol for a mixed methods systematic review |
topic | Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299679/ https://www.ncbi.nlm.nih.gov/pubmed/34294151 http://dx.doi.org/10.1186/s13643-021-01761-y |
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