Lenalidomide-Induced Myocarditis, Rare But Possibly Fatal Toxicity of a Commonly Used Immunotherapy

A 66-year-old woman with follicular lymphoma on lenalidomide and rituximab presented with chest pain. High-sensitivity troponin T peaked at 7,566 ng/l. Cardiac biopsy revealed extensive inflammation consistent with medication-induced myocarditis. Lenalidomide was stopped with improvement in troponin...

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Detalles Bibliográficos
Autores principales: Jacob, Robin, Strati, Paolo, Palaskas, Nicolas, Lopez-Mattei, Juan C., Marmagkiolis, Konstantinos, Buja, L. Maximilian, Deswal, Anita, Iliescu, Cezar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Mini-Focus Issue: Cardiomyopathies and Myocarditis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299772/
https://www.ncbi.nlm.nih.gov/pubmed/34317115
http://dx.doi.org/10.1016/j.jaccas.2020.07.033
Descripción
Sumario:A 66-year-old woman with follicular lymphoma on lenalidomide and rituximab presented with chest pain. High-sensitivity troponin T peaked at 7,566 ng/l. Cardiac biopsy revealed extensive inflammation consistent with medication-induced myocarditis. Lenalidomide was stopped with improvement in troponins and patient was initiated on high-dose corticosteroid therapy. (Level of Difficulty: Intermediate.)

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