Lenalidomide-Induced Myocarditis, Rare But Possibly Fatal Toxicity of a Commonly Used Immunotherapy

A 66-year-old woman with follicular lymphoma on lenalidomide and rituximab presented with chest pain. High-sensitivity troponin T peaked at 7,566 ng/l. Cardiac biopsy revealed extensive inflammation consistent with medication-induced myocarditis. Lenalidomide was stopped with improvement in troponin...

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Autores principales: Jacob, Robin, Strati, Paolo, Palaskas, Nicolas, Lopez-Mattei, Juan C., Marmagkiolis, Konstantinos, Buja, L. Maximilian, Deswal, Anita, Iliescu, Cezar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Mini-Focus Issue: Cardiomyopathies and Myocarditis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299772/
https://www.ncbi.nlm.nih.gov/pubmed/34317115
http://dx.doi.org/10.1016/j.jaccas.2020.07.033
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author Jacob, Robin
Strati, Paolo
Palaskas, Nicolas
Lopez-Mattei, Juan C.
Marmagkiolis, Konstantinos
Buja, L. Maximilian
Deswal, Anita
Iliescu, Cezar
author_facet Jacob, Robin
Strati, Paolo
Palaskas, Nicolas
Lopez-Mattei, Juan C.
Marmagkiolis, Konstantinos
Buja, L. Maximilian
Deswal, Anita
Iliescu, Cezar
author_sort Jacob, Robin
collection PubMed
description A 66-year-old woman with follicular lymphoma on lenalidomide and rituximab presented with chest pain. High-sensitivity troponin T peaked at 7,566 ng/l. Cardiac biopsy revealed extensive inflammation consistent with medication-induced myocarditis. Lenalidomide was stopped with improvement in troponins and patient was initiated on high-dose corticosteroid therapy. (Level of Difficulty: Intermediate.)
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spelling pubmed-82997722021-07-26 Lenalidomide-Induced Myocarditis, Rare But Possibly Fatal Toxicity of a Commonly Used Immunotherapy Jacob, Robin Strati, Paolo Palaskas, Nicolas Lopez-Mattei, Juan C. Marmagkiolis, Konstantinos Buja, L. Maximilian Deswal, Anita Iliescu, Cezar JACC Case Rep Mini-Focus Issue: Cardiomyopathies and Myocarditis A 66-year-old woman with follicular lymphoma on lenalidomide and rituximab presented with chest pain. High-sensitivity troponin T peaked at 7,566 ng/l. Cardiac biopsy revealed extensive inflammation consistent with medication-induced myocarditis. Lenalidomide was stopped with improvement in troponins and patient was initiated on high-dose corticosteroid therapy. (Level of Difficulty: Intermediate.) Elsevier 2020-09-30 /pmc/articles/PMC8299772/ /pubmed/34317115 http://dx.doi.org/10.1016/j.jaccas.2020.07.033 Text en © 2020 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Mini-Focus Issue: Cardiomyopathies and Myocarditis
Jacob, Robin
Strati, Paolo
Palaskas, Nicolas
Lopez-Mattei, Juan C.
Marmagkiolis, Konstantinos
Buja, L. Maximilian
Deswal, Anita
Iliescu, Cezar
Lenalidomide-Induced Myocarditis, Rare But Possibly Fatal Toxicity of a Commonly Used Immunotherapy
title Lenalidomide-Induced Myocarditis, Rare But Possibly Fatal Toxicity of a Commonly Used Immunotherapy
title_full Lenalidomide-Induced Myocarditis, Rare But Possibly Fatal Toxicity of a Commonly Used Immunotherapy
title_fullStr Lenalidomide-Induced Myocarditis, Rare But Possibly Fatal Toxicity of a Commonly Used Immunotherapy
title_full_unstemmed Lenalidomide-Induced Myocarditis, Rare But Possibly Fatal Toxicity of a Commonly Used Immunotherapy
title_short Lenalidomide-Induced Myocarditis, Rare But Possibly Fatal Toxicity of a Commonly Used Immunotherapy
title_sort lenalidomide-induced myocarditis, rare but possibly fatal toxicity of a commonly used immunotherapy
topic Mini-Focus Issue: Cardiomyopathies and Myocarditis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299772/
https://www.ncbi.nlm.nih.gov/pubmed/34317115
http://dx.doi.org/10.1016/j.jaccas.2020.07.033
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