Cargando…

T-Cell Exhaustion Status Under High and Low Levels of Hypoxia-Inducible Factor 1α Expression in Glioma

Background: Hypoxia-inducible factor 1α (HIF1A), the principal regulator of hypoxia, is involved in the suppression of antitumor immunity. We aimed to describe the T-cell exhaustion status of gliomas under different levels of HIF1A expression. Methods: In this study, 692 patients, whose data were co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Shuai, Liu, Xing, Zhang, Chuanbao, Shan, Wei, Qiu, Xiaoguang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8299942/ https://www.ncbi.nlm.nih.gov/pubmed/34305618 http://dx.doi.org/10.3389/fphar.2021.711772

Ejemplares similares

Thymoquinone affects the gemcitabine sensitivity of pancreatic cancer by regulating collagen via hypoxia inducible factor-1α
por: Zhao, Zhanxue, et al.
Publicado: (2023)

Ginsenoside Re Treatment Attenuates Myocardial Hypoxia/Reoxygenation Injury by Inhibiting HIF-1α Ubiquitination
por: Sun, Huiyuan, et al.
Publicado: (2020)

Targeting Hypoxia Inducible Factors-1α As a Novel Therapy in Fibrosis
por: Xiong, Anji, et al.
Publicado: (2017)

Spatial immune heterogeneity of hypoxia-induced exhausted features in high-grade glioma
por: Kim, A-Reum, et al.
Publicado: (2022)

Sevoflurane Postconditioning Attenuates Hypoxia/Reoxygenation Injury of Cardiomyocytes Under High Glucose by Regulating HIF-1α/MIF/AMPK Pathway
por: Ma, Haiping, et al.
Publicado: (2021)

Roles of hypoxia-inducible factor in hepatocellular carcinoma under local ablation therapies
por: Xiao, Chunying, et al.
Publicado: (2023)

The relationship between expression of PD-L1 and HIF-1α in glioma cells under hypoxia
por: Ding, Xing-chen, et al.
Publicado: (2021)

Regulation of CYP450 and drug transporter mediated by gut microbiota under high-altitude hypoxia
por: Bai, Xue, et al.
Publicado: (2022)

The Prognostic and Therapeutic Value of PD-L1 in Glioma
por: Chen, Ruo Qiao, et al.
Publicado: (2019)

Long-term adjuvant administration of temozolomide impacts serum ions concentration in high-grade glioma
por: Zhong, Liyun, et al.
Publicado: (2022)

A novel T-cell exhaustion-related feature can accurately predict the prognosis of OC patients
por: Yuan, Kemiao, et al.
Publicado: (2023)

Low-Intensity Pulsed Ultrasound Alleviates Hypoxia-Induced Chondrocyte Damage in Temporomandibular Disorders by Modulating the Hypoxia-Inducible Factor Pathway
por: Yang, Tao, et al.
Publicado: (2020)

High-dose radiation associated with improved survival in IDH-wildtype low-grade glioma
por: Liu, Shuai, et al.
Publicado: (2021)

Hypoxia and Hypoxia-Inducible Factors in Lymphedema
por: Jiang, Xinguo, et al.
Publicado: (2022)

The Protective Effect of Quercetin on Endothelial Cells Injured by Hypoxia and Reoxygenation
por: Li, Meng-Ting, et al.
Publicado: (2021)

Disulfiram in glioma: Literature review of drug repurposing
por: Zhong, Shiyu, et al.
Publicado: (2022)

Research Progress About Glioma Stem Cells in the Immune Microenvironment of Glioma
por: Li, Xiangyu, et al.
Publicado: (2021)

Rechallenge to Carboplatin in Children with Low Grade Glioma and Carboplatin Hypersensitivity Reactions
por: Ruggiero, Antonio, et al.
Publicado: (2017)

Comprehensive analysis of hypoxia-related genes for prognosis value, immune status, and therapy in osteosarcoma patients
por: Han, Tao, et al.
Publicado: (2023)

Hirsutella Sinensis Fungus Regulates CD8(+) T Cell Exhaustion Through Involvement of T-Bet/Eomes in the Tumor Microenvironment
por: Jin, Lu, et al.
Publicado: (2021)

Differences of macrophages in the tumor microenvironment as an underlying key factor in glioma patients
por: Wang, Yangyang, et al.
Publicado: (2022)

Saikosaponin-d Inhibits the Hepatoma Cells and Enhances Chemosensitivity Through SENP5-Dependent Inhibition of Gli1 SUMOylation Under Hypoxia
por: Zhang, Chun-Yan, et al.
Publicado: (2019)

Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions
por: Miyazaki, Yukiko, et al.
Publicado: (2018)

Trimetazidine Attenuates Exhaustive Exercise-Induced Myocardial Injury in Rats via Regulation of the Nrf2/NF-κB Signaling Pathway
por: Zhang, Hongming, et al.
Publicado: (2019)

The Hypoxia-Activated Prodrug TH-302: Exploiting Hypoxia in Cancer Therapy
por: Li, Yue, et al.
Publicado: (2021)

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion
por: Scharping, Nicole E., et al.
Publicado: (2021)

Liraglutide Increases VEGF Expression via CNPY2-PERK Pathway Induced by Hypoxia/Reoxygenation Injury
por: Liu, Chong, et al.
Publicado: (2019)

Sanguinarine Reverses Pulmonary Vascular Remolding of Hypoxia-Induced PH via Survivin/HIF1α-Attenuating Kv Channels
por: Fan, Fenling, et al.
Publicado: (2021)

Metabonomic Analysis of the Therapeutic Effects of Chinese Medicine Sanqi Oral Solution on Rats With Exhaustive Exercise
por: Xu, Peng, et al.
Publicado: (2019)

A systematic and comprehensive analysis of T cell exhaustion related to therapy in lung adenocarcinoma tumor microenvironment
por: Hu, Peipei, et al.
Publicado: (2023)

A multifunctional oxidative stress nanoamplifier with ROS amplification and GSH exhaustion for enhanced chemodynamic therapy
por: Zhong, Wenzhao, et al.
Publicado: (2022)

A ROCK1 Inhibitior Fasudil Alleviates Cardiomyocyte Apoptosis in Diabetic Cardiomyopathy by Inhibiting Mitochondrial Fission in a Type 2 Diabetes Mouse Model
por: Fan, Xinhui, et al.
Publicado: (2022)

Synthesis and Evaluations of Novel Apocynin Derivatives as Anti-Glioma Agents
por: Yang, Tao, et al.
Publicado: (2019)

Bibliometric analysis of hypoxia inducible factor prolyl hydroxylase inhibitor in anemia
por: Zheng, Li, et al.
Publicado: (2022)

Molecular and clinical characterization of PD-L1 expression at transcriptional level via 976 samples of brain glioma
por: Wang, Zheng, et al.
Publicado: (2016)

Comprehensive Analysis of Inflammatory Response–Related Genes, and Prognosis and Immune Infiltration in Patients With Low-Grade Glioma
por: Han, Tao, et al.
Publicado: (2021)

Global Pattern of CD8(+) T-Cell Infiltration and Exhaustion in Colorectal Cancer Predicts Cancer Immunotherapy Response
por: Tian, Sun, et al.
Publicado: (2021)

Cuproptosis-related molecular subtypes direct T cell exhaustion phenotypes and therapeutic strategies for patients with lung adenocarcinoma
por: Zhu, Yi-Pan, et al.
Publicado: (2023)

Systematic analysis of the necroptosis index in pan-cancer and classification in discriminating the prognosis and immunotherapy responses of 1716 glioma patients
por: Ma, Shuai, et al.
Publicado: (2023)

Association of high‐dose radiotherapy with improved survival in patients with newly diagnosed low‐grade gliomas
por: Liu, Yanwei, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_rrd4ldsdhq95e8m9hakp3cpbhn