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Individualized Glaucoma Change Detection Using Deep Learning Auto Encoder-Based Regions of Interest
PURPOSE: To compare change over time in eye-specific optical coherence tomography (OCT) retinal nerve fiber layer (RNFL)-based region-of-interest (ROI) maps developed using unsupervised deep-learning auto-encoders (DL-AE) to circumpapillary RNFL (cpRNFL) thickness for the detection of glaucomatous p...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300051/ https://www.ncbi.nlm.nih.gov/pubmed/34293095 http://dx.doi.org/10.1167/tvst.10.8.19 |
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author | Bowd, Christopher Belghith, Akram Christopher, Mark Goldbaum, Michael H. Fazio, Massimo A. Girkin, Christopher A. Liebmann, Jeffrey M. de Moraes, Carlos Gustavo Weinreb, Robert N. Zangwill, Linda M. |
author_facet | Bowd, Christopher Belghith, Akram Christopher, Mark Goldbaum, Michael H. Fazio, Massimo A. Girkin, Christopher A. Liebmann, Jeffrey M. de Moraes, Carlos Gustavo Weinreb, Robert N. Zangwill, Linda M. |
author_sort | Bowd, Christopher |
collection | PubMed |
description | PURPOSE: To compare change over time in eye-specific optical coherence tomography (OCT) retinal nerve fiber layer (RNFL)-based region-of-interest (ROI) maps developed using unsupervised deep-learning auto-encoders (DL-AE) to circumpapillary RNFL (cpRNFL) thickness for the detection of glaucomatous progression. METHODS: Forty-four progressing glaucoma eyes (by stereophotograph assessment), 189 nonprogressing glaucoma eyes (by stereophotograph assessment), and 109 healthy eyes were followed for ≥3 years with ≥4 visits using OCT. The San Diego Automated Layer Segmentation Algorithm was used to automatically segment the RNFL layer from raw three-dimensional OCT images. For each longitudinal series, DL-AEs were used to generate individualized eye-based ROI maps by identifying RNFL regions of likely progression and no change. Sensitivities and specificities for detecting change over time and rates of change over time were compared for the DL-AE ROI and global cpRNFL thickness measurements derived from a 2.22-mm to 3.45-mm annulus centered on the optic disc. RESULTS: The sensitivity for detecting change in progressing eyes was greater for DL-AE ROIs than for global cpRNFL annulus thicknesses (0.90 and 0.63, respectively). The specificity for detecting not likely progression in nonprogressing eyes was similar (0.92 and 0.93, respectively). The mean rates of change in DL-AE ROI were significantly faster than for cpRNFL annulus thickness in progressing eyes (−1.28 µm/y vs. −0.83 µm/y) and nonprogressing eyes (−1.03 µm/y vs. −0.78 µm/y). CONCLUSIONS: Eye-specific ROIs identified using DL-AE analysis of OCT images show promise for improving assessment of glaucomatous progression. TRANSLATIONAL RELEVANCE: The detection and monitoring of structural glaucomatous progression can be improved by considering eye-specific regions of likely progression identified using deep learning. |
format | Online Article Text |
id | pubmed-8300051 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Association for Research in Vision and Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-83000512021-07-28 Individualized Glaucoma Change Detection Using Deep Learning Auto Encoder-Based Regions of Interest Bowd, Christopher Belghith, Akram Christopher, Mark Goldbaum, Michael H. Fazio, Massimo A. Girkin, Christopher A. Liebmann, Jeffrey M. de Moraes, Carlos Gustavo Weinreb, Robert N. Zangwill, Linda M. Transl Vis Sci Technol Article PURPOSE: To compare change over time in eye-specific optical coherence tomography (OCT) retinal nerve fiber layer (RNFL)-based region-of-interest (ROI) maps developed using unsupervised deep-learning auto-encoders (DL-AE) to circumpapillary RNFL (cpRNFL) thickness for the detection of glaucomatous progression. METHODS: Forty-four progressing glaucoma eyes (by stereophotograph assessment), 189 nonprogressing glaucoma eyes (by stereophotograph assessment), and 109 healthy eyes were followed for ≥3 years with ≥4 visits using OCT. The San Diego Automated Layer Segmentation Algorithm was used to automatically segment the RNFL layer from raw three-dimensional OCT images. For each longitudinal series, DL-AEs were used to generate individualized eye-based ROI maps by identifying RNFL regions of likely progression and no change. Sensitivities and specificities for detecting change over time and rates of change over time were compared for the DL-AE ROI and global cpRNFL thickness measurements derived from a 2.22-mm to 3.45-mm annulus centered on the optic disc. RESULTS: The sensitivity for detecting change in progressing eyes was greater for DL-AE ROIs than for global cpRNFL annulus thicknesses (0.90 and 0.63, respectively). The specificity for detecting not likely progression in nonprogressing eyes was similar (0.92 and 0.93, respectively). The mean rates of change in DL-AE ROI were significantly faster than for cpRNFL annulus thickness in progressing eyes (−1.28 µm/y vs. −0.83 µm/y) and nonprogressing eyes (−1.03 µm/y vs. −0.78 µm/y). CONCLUSIONS: Eye-specific ROIs identified using DL-AE analysis of OCT images show promise for improving assessment of glaucomatous progression. TRANSLATIONAL RELEVANCE: The detection and monitoring of structural glaucomatous progression can be improved by considering eye-specific regions of likely progression identified using deep learning. The Association for Research in Vision and Ophthalmology 2021-07-22 /pmc/articles/PMC8300051/ /pubmed/34293095 http://dx.doi.org/10.1167/tvst.10.8.19 Text en Copyright 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
spellingShingle | Article Bowd, Christopher Belghith, Akram Christopher, Mark Goldbaum, Michael H. Fazio, Massimo A. Girkin, Christopher A. Liebmann, Jeffrey M. de Moraes, Carlos Gustavo Weinreb, Robert N. Zangwill, Linda M. Individualized Glaucoma Change Detection Using Deep Learning Auto Encoder-Based Regions of Interest |
title | Individualized Glaucoma Change Detection Using Deep Learning Auto Encoder-Based Regions of Interest |
title_full | Individualized Glaucoma Change Detection Using Deep Learning Auto Encoder-Based Regions of Interest |
title_fullStr | Individualized Glaucoma Change Detection Using Deep Learning Auto Encoder-Based Regions of Interest |
title_full_unstemmed | Individualized Glaucoma Change Detection Using Deep Learning Auto Encoder-Based Regions of Interest |
title_short | Individualized Glaucoma Change Detection Using Deep Learning Auto Encoder-Based Regions of Interest |
title_sort | individualized glaucoma change detection using deep learning auto encoder-based regions of interest |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300051/ https://www.ncbi.nlm.nih.gov/pubmed/34293095 http://dx.doi.org/10.1167/tvst.10.8.19 |
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