Developing Recommendations for Cumulative Endpoints and Lifetime Use for Research Animals

SIMPLE SUMMARY: The welfare of research animals should be a top priority in any research program, and that includes their long-term welfare. Animals may be used in multiple experiments or used for training purposes, which may lead to cumulative suffering. To prevent this, humane endpoints need to be defined specifying limits on experiments, procedures, and time that animals are used for research. There are few resources available for deciding which criteria to use when making endpoint decisions. The purpose of this paper is to present results of a survey identifying laboratory animal professionals’ attitudes and institutional strategies regarding cumulative endpoints, review regulations and tools addressing cumulative welfare in research animals and provide recommendations for how to move forward addressing this issue. While institutions may have endpoint guidelines in place, many of them only cover certain species or may be informal. There is a need for more specific guidelines that allow for the diversity of experiments using animals. Welfare assessment tools could help provide objective guidance on humane endpoints for research animals. Further research on which tools are the most efficient and comprehensive would be beneficial in improving animal welfare as well as the quality of the science using research animals. ABSTRACT: Research animals are important for scientific advancement, and therefore, their long-term welfare needs to be monitored to not only minimize suffering, but to provide positive affective states and experiences. Currently, there is limited guidance in countries around the world on cumulative and experimental endpoints. This paper aims to explore current opinions and institutional strategies regarding cumulative use and endpoints through a scoping survey and review of current regulations and welfare assessment tools, and ultimately to provide recommendations for assessment of cumulative and lifetime use of research animals. The survey found that only 36% of respondents indicated that their institution had cumulative use endpoint policies in place, but these policies may be informal and/or vary by species. Most respondents supported more specific guidelines but expressed concerns about formal policies that may limit their ability to make case-by-case decisions. The wide diversity in how research animals are used makes it difficult for specific policies to be implemented. Endpoint decisions should be made in an objective manner using standardized welfare assessment tools. Future research should focus on robust, efficient welfare assessment tools that can be used to support planning and recommendations for cumulative endpoints and lifetime use of research and teaching animals.