Cargando…

Performance and drug deposition of kappa-carrageenan microspheres encapsulating ciprofloxacin HCl: Effect of polymer concentration

It has been known that in respiratory disease, antibiotic is selected for respiratory diseases or lung infections and this research focused on ciprofloxacin HCl as a model. The aim was to evaluate the effect of kappa-carrageenan polymer concentrations on characteristics, release, and drug deposition...

Descripción completa

Detalles Bibliográficos
Autores principales: Hariyadi, Dewi Melani, Purwanti, Tutiek, Maulydia, Dinda, Estherline, Cindy Alicia, Hendradi, Esti, Rahmadi, Mahardian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300320/
https://www.ncbi.nlm.nih.gov/pubmed/34345602
http://dx.doi.org/10.4103/japtr.JAPTR_197_21
_version_ 1783726445815660544
author Hariyadi, Dewi Melani
Purwanti, Tutiek
Maulydia, Dinda
Estherline, Cindy Alicia
Hendradi, Esti
Rahmadi, Mahardian
author_facet Hariyadi, Dewi Melani
Purwanti, Tutiek
Maulydia, Dinda
Estherline, Cindy Alicia
Hendradi, Esti
Rahmadi, Mahardian
author_sort Hariyadi, Dewi Melani
collection PubMed
description It has been known that in respiratory disease, antibiotic is selected for respiratory diseases or lung infections and this research focused on ciprofloxacin HCl as a model. The aim was to evaluate the effect of kappa-carrageenan polymer concentrations on characteristics, release, and drug deposition in the lung. Ciprofloxacin HCl-carrageenan microspheres were produced with kappa carrageenan (0.75%, 0.50%, and 0.25%) as polymer and KCl (1.5%) as crosslinker. Physical characteristics were included morphology, size, moisture content, swelling index, mucoadhesivity, drug loading, entrapment efficiency, and yield. Freeze-dried microspheres were inhaled by animal, and drug deposition was observed. Results showed that dried, smooth, and spherical microspheres of size of 1.34 to 1.70 μm and loading of 15.63% to 38.72%. Entrapment efficiency and yield were 25.38%–51.61% and 52.53%–63.19%, respectively. Mucoadhesivity was 0.0059–0.0096 kg force, and release in 24 h was 74.38%–81.02%. Release kinetics demonstrated Higuchi mechanism. Increasing carrageenan concentration affected size, loading, and efficiency but did not influence adhesivity, yield, and release. Higher amount of polymer caused the lower deposit on the lungs. Respirable size of ciprofloxacin HCl-kappa carrageenan microspheres was successfully achieved target site and prolonged residence time in lungs.
format Online
Article
Text
id pubmed-8300320
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-83003202021-08-02 Performance and drug deposition of kappa-carrageenan microspheres encapsulating ciprofloxacin HCl: Effect of polymer concentration Hariyadi, Dewi Melani Purwanti, Tutiek Maulydia, Dinda Estherline, Cindy Alicia Hendradi, Esti Rahmadi, Mahardian J Adv Pharm Technol Res Original Article It has been known that in respiratory disease, antibiotic is selected for respiratory diseases or lung infections and this research focused on ciprofloxacin HCl as a model. The aim was to evaluate the effect of kappa-carrageenan polymer concentrations on characteristics, release, and drug deposition in the lung. Ciprofloxacin HCl-carrageenan microspheres were produced with kappa carrageenan (0.75%, 0.50%, and 0.25%) as polymer and KCl (1.5%) as crosslinker. Physical characteristics were included morphology, size, moisture content, swelling index, mucoadhesivity, drug loading, entrapment efficiency, and yield. Freeze-dried microspheres were inhaled by animal, and drug deposition was observed. Results showed that dried, smooth, and spherical microspheres of size of 1.34 to 1.70 μm and loading of 15.63% to 38.72%. Entrapment efficiency and yield were 25.38%–51.61% and 52.53%–63.19%, respectively. Mucoadhesivity was 0.0059–0.0096 kg force, and release in 24 h was 74.38%–81.02%. Release kinetics demonstrated Higuchi mechanism. Increasing carrageenan concentration affected size, loading, and efficiency but did not influence adhesivity, yield, and release. Higher amount of polymer caused the lower deposit on the lungs. Respirable size of ciprofloxacin HCl-kappa carrageenan microspheres was successfully achieved target site and prolonged residence time in lungs. Wolters Kluwer - Medknow 2021 2021-07-16 /pmc/articles/PMC8300320/ /pubmed/34345602 http://dx.doi.org/10.4103/japtr.JAPTR_197_21 Text en Copyright: © 2021 Journal of Advanced Pharmaceutical Technology & Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Hariyadi, Dewi Melani
Purwanti, Tutiek
Maulydia, Dinda
Estherline, Cindy Alicia
Hendradi, Esti
Rahmadi, Mahardian
Performance and drug deposition of kappa-carrageenan microspheres encapsulating ciprofloxacin HCl: Effect of polymer concentration
title Performance and drug deposition of kappa-carrageenan microspheres encapsulating ciprofloxacin HCl: Effect of polymer concentration
title_full Performance and drug deposition of kappa-carrageenan microspheres encapsulating ciprofloxacin HCl: Effect of polymer concentration
title_fullStr Performance and drug deposition of kappa-carrageenan microspheres encapsulating ciprofloxacin HCl: Effect of polymer concentration
title_full_unstemmed Performance and drug deposition of kappa-carrageenan microspheres encapsulating ciprofloxacin HCl: Effect of polymer concentration
title_short Performance and drug deposition of kappa-carrageenan microspheres encapsulating ciprofloxacin HCl: Effect of polymer concentration
title_sort performance and drug deposition of kappa-carrageenan microspheres encapsulating ciprofloxacin hcl: effect of polymer concentration
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300320/
https://www.ncbi.nlm.nih.gov/pubmed/34345602
http://dx.doi.org/10.4103/japtr.JAPTR_197_21
work_keys_str_mv AT hariyadidewimelani performanceanddrugdepositionofkappacarrageenanmicrospheresencapsulatingciprofloxacinhcleffectofpolymerconcentration
AT purwantitutiek performanceanddrugdepositionofkappacarrageenanmicrospheresencapsulatingciprofloxacinhcleffectofpolymerconcentration
AT maulydiadinda performanceanddrugdepositionofkappacarrageenanmicrospheresencapsulatingciprofloxacinhcleffectofpolymerconcentration
AT estherlinecindyalicia performanceanddrugdepositionofkappacarrageenanmicrospheresencapsulatingciprofloxacinhcleffectofpolymerconcentration
AT hendradiesti performanceanddrugdepositionofkappacarrageenanmicrospheresencapsulatingciprofloxacinhcleffectofpolymerconcentration
AT rahmadimahardian performanceanddrugdepositionofkappacarrageenanmicrospheresencapsulatingciprofloxacinhcleffectofpolymerconcentration