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Performance and drug deposition of kappa-carrageenan microspheres encapsulating ciprofloxacin HCl: Effect of polymer concentration
It has been known that in respiratory disease, antibiotic is selected for respiratory diseases or lung infections and this research focused on ciprofloxacin HCl as a model. The aim was to evaluate the effect of kappa-carrageenan polymer concentrations on characteristics, release, and drug deposition...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300320/ https://www.ncbi.nlm.nih.gov/pubmed/34345602 http://dx.doi.org/10.4103/japtr.JAPTR_197_21 |
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author | Hariyadi, Dewi Melani Purwanti, Tutiek Maulydia, Dinda Estherline, Cindy Alicia Hendradi, Esti Rahmadi, Mahardian |
author_facet | Hariyadi, Dewi Melani Purwanti, Tutiek Maulydia, Dinda Estherline, Cindy Alicia Hendradi, Esti Rahmadi, Mahardian |
author_sort | Hariyadi, Dewi Melani |
collection | PubMed |
description | It has been known that in respiratory disease, antibiotic is selected for respiratory diseases or lung infections and this research focused on ciprofloxacin HCl as a model. The aim was to evaluate the effect of kappa-carrageenan polymer concentrations on characteristics, release, and drug deposition in the lung. Ciprofloxacin HCl-carrageenan microspheres were produced with kappa carrageenan (0.75%, 0.50%, and 0.25%) as polymer and KCl (1.5%) as crosslinker. Physical characteristics were included morphology, size, moisture content, swelling index, mucoadhesivity, drug loading, entrapment efficiency, and yield. Freeze-dried microspheres were inhaled by animal, and drug deposition was observed. Results showed that dried, smooth, and spherical microspheres of size of 1.34 to 1.70 μm and loading of 15.63% to 38.72%. Entrapment efficiency and yield were 25.38%–51.61% and 52.53%–63.19%, respectively. Mucoadhesivity was 0.0059–0.0096 kg force, and release in 24 h was 74.38%–81.02%. Release kinetics demonstrated Higuchi mechanism. Increasing carrageenan concentration affected size, loading, and efficiency but did not influence adhesivity, yield, and release. Higher amount of polymer caused the lower deposit on the lungs. Respirable size of ciprofloxacin HCl-kappa carrageenan microspheres was successfully achieved target site and prolonged residence time in lungs. |
format | Online Article Text |
id | pubmed-8300320 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-83003202021-08-02 Performance and drug deposition of kappa-carrageenan microspheres encapsulating ciprofloxacin HCl: Effect of polymer concentration Hariyadi, Dewi Melani Purwanti, Tutiek Maulydia, Dinda Estherline, Cindy Alicia Hendradi, Esti Rahmadi, Mahardian J Adv Pharm Technol Res Original Article It has been known that in respiratory disease, antibiotic is selected for respiratory diseases or lung infections and this research focused on ciprofloxacin HCl as a model. The aim was to evaluate the effect of kappa-carrageenan polymer concentrations on characteristics, release, and drug deposition in the lung. Ciprofloxacin HCl-carrageenan microspheres were produced with kappa carrageenan (0.75%, 0.50%, and 0.25%) as polymer and KCl (1.5%) as crosslinker. Physical characteristics were included morphology, size, moisture content, swelling index, mucoadhesivity, drug loading, entrapment efficiency, and yield. Freeze-dried microspheres were inhaled by animal, and drug deposition was observed. Results showed that dried, smooth, and spherical microspheres of size of 1.34 to 1.70 μm and loading of 15.63% to 38.72%. Entrapment efficiency and yield were 25.38%–51.61% and 52.53%–63.19%, respectively. Mucoadhesivity was 0.0059–0.0096 kg force, and release in 24 h was 74.38%–81.02%. Release kinetics demonstrated Higuchi mechanism. Increasing carrageenan concentration affected size, loading, and efficiency but did not influence adhesivity, yield, and release. Higher amount of polymer caused the lower deposit on the lungs. Respirable size of ciprofloxacin HCl-kappa carrageenan microspheres was successfully achieved target site and prolonged residence time in lungs. Wolters Kluwer - Medknow 2021 2021-07-16 /pmc/articles/PMC8300320/ /pubmed/34345602 http://dx.doi.org/10.4103/japtr.JAPTR_197_21 Text en Copyright: © 2021 Journal of Advanced Pharmaceutical Technology & Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Hariyadi, Dewi Melani Purwanti, Tutiek Maulydia, Dinda Estherline, Cindy Alicia Hendradi, Esti Rahmadi, Mahardian Performance and drug deposition of kappa-carrageenan microspheres encapsulating ciprofloxacin HCl: Effect of polymer concentration |
title | Performance and drug deposition of kappa-carrageenan microspheres encapsulating ciprofloxacin HCl: Effect of polymer concentration |
title_full | Performance and drug deposition of kappa-carrageenan microspheres encapsulating ciprofloxacin HCl: Effect of polymer concentration |
title_fullStr | Performance and drug deposition of kappa-carrageenan microspheres encapsulating ciprofloxacin HCl: Effect of polymer concentration |
title_full_unstemmed | Performance and drug deposition of kappa-carrageenan microspheres encapsulating ciprofloxacin HCl: Effect of polymer concentration |
title_short | Performance and drug deposition of kappa-carrageenan microspheres encapsulating ciprofloxacin HCl: Effect of polymer concentration |
title_sort | performance and drug deposition of kappa-carrageenan microspheres encapsulating ciprofloxacin hcl: effect of polymer concentration |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300320/ https://www.ncbi.nlm.nih.gov/pubmed/34345602 http://dx.doi.org/10.4103/japtr.JAPTR_197_21 |
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