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Review: Effect of Gut Microbiota and Its Metabolite SCFAs on Radiation-Induced Intestinal Injury

Gut microbiota is regarded as the second human genome and forgotten organ, which is symbiotic with the human host and cannot live and exist alone. The gut microbiota performs multiple physiological functions and plays a pivotal role in host health and intestinal homeostasis. However, the gut microbi...

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Autores principales: Li, Yangyang, Zhang, Yiming, Wei, Kongxi, He, Jinpeng, Ding, Nan, Hua, Junrui, Zhou, Ting, Niu, Fan, Zhou, Gucheng, Shi, Tongfan, Zhang, Liying, Liu, Yongqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300561/
https://www.ncbi.nlm.nih.gov/pubmed/34307184
http://dx.doi.org/10.3389/fcimb.2021.577236
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author Li, Yangyang
Zhang, Yiming
Wei, Kongxi
He, Jinpeng
Ding, Nan
Hua, Junrui
Zhou, Ting
Niu, Fan
Zhou, Gucheng
Shi, Tongfan
Zhang, Liying
Liu, Yongqi
author_facet Li, Yangyang
Zhang, Yiming
Wei, Kongxi
He, Jinpeng
Ding, Nan
Hua, Junrui
Zhou, Ting
Niu, Fan
Zhou, Gucheng
Shi, Tongfan
Zhang, Liying
Liu, Yongqi
author_sort Li, Yangyang
collection PubMed
description Gut microbiota is regarded as the second human genome and forgotten organ, which is symbiotic with the human host and cannot live and exist alone. The gut microbiota performs multiple physiological functions and plays a pivotal role in host health and intestinal homeostasis. However, the gut microbiota can always be affected by various factors and among them, it is radiotherapy that results in gut microbiota dysbiosis and it is often embodied in a decrease in the abundance and diversity of gut microbiota, an increase in harmful bacteria and a decrease in beneficial bacteria, thereby affecting many disease states, especially intestine diseases. Furthermore, gut microbiota can produce a variety of metabolites, among which short-chain fatty acids (SCFAs) are one of the most abundant and important metabolites. More importantly, SCFAs can be identified as second messengers to promote signal transduction and affect the occurrence and development of diseases. Radiotherapy can lead to the alterations of SCFAs-producing bacteria and cause changes in SCFAs, which is associated with a variety of diseases such as radiation-induced intestinal injury. However, the specific mechanism of its occurrence is not yet clear. Therefore, this review intends to emphasize the alterations of gut microbiota after radiotherapy and highlight the alterations of SCFAs-producing bacteria and SCFAs to explore the mechanisms of radiation-induced intestinal injury from the perspective of gut microbiota and its metabolite SCFAs.
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spelling pubmed-83005612021-07-24 Review: Effect of Gut Microbiota and Its Metabolite SCFAs on Radiation-Induced Intestinal Injury Li, Yangyang Zhang, Yiming Wei, Kongxi He, Jinpeng Ding, Nan Hua, Junrui Zhou, Ting Niu, Fan Zhou, Gucheng Shi, Tongfan Zhang, Liying Liu, Yongqi Front Cell Infect Microbiol Cellular and Infection Microbiology Gut microbiota is regarded as the second human genome and forgotten organ, which is symbiotic with the human host and cannot live and exist alone. The gut microbiota performs multiple physiological functions and plays a pivotal role in host health and intestinal homeostasis. However, the gut microbiota can always be affected by various factors and among them, it is radiotherapy that results in gut microbiota dysbiosis and it is often embodied in a decrease in the abundance and diversity of gut microbiota, an increase in harmful bacteria and a decrease in beneficial bacteria, thereby affecting many disease states, especially intestine diseases. Furthermore, gut microbiota can produce a variety of metabolites, among which short-chain fatty acids (SCFAs) are one of the most abundant and important metabolites. More importantly, SCFAs can be identified as second messengers to promote signal transduction and affect the occurrence and development of diseases. Radiotherapy can lead to the alterations of SCFAs-producing bacteria and cause changes in SCFAs, which is associated with a variety of diseases such as radiation-induced intestinal injury. However, the specific mechanism of its occurrence is not yet clear. Therefore, this review intends to emphasize the alterations of gut microbiota after radiotherapy and highlight the alterations of SCFAs-producing bacteria and SCFAs to explore the mechanisms of radiation-induced intestinal injury from the perspective of gut microbiota and its metabolite SCFAs. Frontiers Media S.A. 2021-07-09 /pmc/articles/PMC8300561/ /pubmed/34307184 http://dx.doi.org/10.3389/fcimb.2021.577236 Text en Copyright © 2021 Li, Zhang, Wei, He, Ding, Hua, Zhou, Niu, Zhou, Shi, Zhang and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Li, Yangyang
Zhang, Yiming
Wei, Kongxi
He, Jinpeng
Ding, Nan
Hua, Junrui
Zhou, Ting
Niu, Fan
Zhou, Gucheng
Shi, Tongfan
Zhang, Liying
Liu, Yongqi
Review: Effect of Gut Microbiota and Its Metabolite SCFAs on Radiation-Induced Intestinal Injury
title Review: Effect of Gut Microbiota and Its Metabolite SCFAs on Radiation-Induced Intestinal Injury
title_full Review: Effect of Gut Microbiota and Its Metabolite SCFAs on Radiation-Induced Intestinal Injury
title_fullStr Review: Effect of Gut Microbiota and Its Metabolite SCFAs on Radiation-Induced Intestinal Injury
title_full_unstemmed Review: Effect of Gut Microbiota and Its Metabolite SCFAs on Radiation-Induced Intestinal Injury
title_short Review: Effect of Gut Microbiota and Its Metabolite SCFAs on Radiation-Induced Intestinal Injury
title_sort review: effect of gut microbiota and its metabolite scfas on radiation-induced intestinal injury
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300561/
https://www.ncbi.nlm.nih.gov/pubmed/34307184
http://dx.doi.org/10.3389/fcimb.2021.577236
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