Cargando…

Triazolo Based-Thiadiazole Derivatives. Synthesis, Biological Evaluation and Molecular Docking Studies

The goal of this research is to investigate the antimicrobial activity of nineteen previously synthesized 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives. The compounds were tested against a panel of three Gram-positive and three Gram-negative bacteria, three resistant strains,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kamoutsis, Charalampos, Fesatidou, Maria, Petrou, Anthi, Geronikaki, Athina, Poroikov, Vladimir, Ivanov, Marija, Soković, Marina, Ćirić, Ana, Carazo, Alejandro, Mladěnka, Přemysl
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300616/ https://www.ncbi.nlm.nih.gov/pubmed/34356726 http://dx.doi.org/10.3390/antibiotics10070804

Ejemplares similares

Antimicrobial Activity of Nitrogen-Containing 5-α-Androstane Derivatives: In Silico and Experimental Studies
por: Amiranashvili, Lela, et al.
Publicado: (2020)

5-Benzyliden-2-(5-methylthiazol-2-ylimino)thiazolidin-4-ones as Antimicrobial Agents. Design, Synthesis, Biological Evaluation and Molecular Docking Studies
por: Haroun, Michelyne, et al.
Publicado: (2021)

Synthesis, Biological Evaluation and Molecular Docking Studies of 5-Indolylmethylen-4-oxo-2-thioxothiazolidine Derivatives
por: Horishny, Volodymyr, et al.
Publicado: (2022)

Thiazole Ring—A Biologically Active Scaffold
por: Petrou, Anthi, et al.
Publicado: (2021)

Chromenol Derivatives as Novel Antifungal Agents: Synthesis, In Silico and In Vitro Evaluation
por: Zveaghintseva, Marina, et al.
Publicado: (2021)

5-(1H-Indol-3-ylmethylene)-4-oxo-2-thioxothiazolidin-3-yl)alkancarboxylic Acids as Antimicrobial Agents: Synthesis, Biological Evaluation, and Molecular Docking Studies
por: Horishny, Volodymyr, et al.
Publicado: (2020)

3-Amino-5-(indol-3-yl)methylene-4-oxo-2-thioxothiazolidine Derivatives as Antimicrobial Agents: Synthesis, Computational and Biological Evaluation
por: Horishny, Volodymyr, et al.
Publicado: (2020)

Synthesis and Antimicrobial Activity of New Heteroaryl(aryl) Thiazole Derivatives Molecular Docking Studies
por: Kartsev, Victor, et al.
Publicado: (2022)

Antimicrobial Activity of Catechol-Containing Biopolymer Poly[3-(3,4-dihydroxyphenyl)glyceric Acid] from Different Medicinal Plants of Boraginaceae Family
por: Barbakadze, Vakhtang, et al.
Publicado: (2023)

Antimicrobial Activity of Some Steroidal Hydrazones
por: Merlani, Maia, et al.
Publicado: (2023)

Thiazolidin-4-Ones as Potential Antimicrobial Agents: Experimental and In Silico Evaluation
por: Tratrat, Christophe, et al.
Publicado: (2022)

Exploration of the Antimicrobial Effects of Benzothiazolylthiazolidin-4-One and In Silico Mechanistic Investigation
por: Haroun, Michelyne, et al.
Publicado: (2021)

Experimental and In Silico Evaluation of New Heteroaryl Benzothiazole Derivatives as Antimicrobial Agents
por: Zubenko, Alexander, et al.
Publicado: (2022)

N-Derivatives of (Z)-Methyl 3-(4-Oxo-2-thioxothiazolidin-5-ylidene)methyl)-1H-indole-2-carboxylates as Antimicrobial Agents—In Silico and In Vitro Evaluation
por: Petrou, Anthi, et al.
Publicado: (2023)

The Synthesis of Triazolium Salts as Antifungal Agents: A Biological and In Silico Evaluation
por: Pogrebnoi, Serghei, et al.
Publicado: (2022)

4-(Indol-3-yl)thiazole-2-amines and 4-ιndol-3-yl)thiazole Acylamines as Νovel Antimicrobial Agents: Synthesis, In Silico and In Vitro Evaluation
por: Simakov, Sergei, et al.
Publicado: (2021)

Thiazole/Thiadiazole/Benzothiazole Based Thiazolidin-4-One Derivatives as Potential Inhibitors of Main Protease of SARS-CoV-2
por: Petrou, Anthi, et al.
Publicado: (2022)

Identification of Novel Cyclooxygenase-1 Selective Inhibitors of Thiadiazole-Based Scaffold as Potent Anti-Inflammatory Agents with Safety Gastric and Cytotoxic Profile
por: Haroun, Michelyne, et al.
Publicado: (2023)

Marine Ligands of the Pregnane X Receptor (PXR): An Overview
por: Carazo, Alejandro, et al.
Publicado: (2019)

Thiazoles and Thiazolidinones as COX/LOX Inhibitors
por: Liaras, Konstantinos, et al.
Publicado: (2018)

New Substituted 5-Benzylideno-2-Adamantylthiazol[3,2-b][1,2,4]Triazol-6(5H)ones as Possible Anti-Inflammatory Agents
por: Tratrat, Christophe, et al.
Publicado: (2021)

In Silico Evaluation of the Effectivity of Approved Protease Inhibitors against the Main Protease of the Novel SARS-CoV-2 Virus
por: Eleftheriou, Phaedra, et al.
Publicado: (2020)

New Heparanase-Inhibiting Triazolo-Thiadiazoles Attenuate Primary Tumor Growth and Metastasis
por: Barash, Uri, et al.
Publicado: (2021)

Identification of Novel Class of Triazolo-Thiadiazoles as Potent Inhibitors of Human Heparanase and their Anticancer Activity
por: Baburajeev, C. P., et al.
Publicado: (2017)

Anticancer Activity of Triazolo-Thiadiazole Derivatives and Inhibition of AKT1 and AKT2 Activation
por: Trafalis, Dimitrios T., et al.
Publicado: (2021)

Discovery of 5-Methylthiazole-Thiazolidinone Conjugates as Potential Anti-Inflammatory Agents: Molecular Target Identification and In Silico Studies
por: Haroun, Michelyne, et al.
Publicado: (2022)

Novel Thiazolidin-4-ones as Potential Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase
por: Petrou, Anthi, et al.
Publicado: (2019)

Discovery of Fused Triazolo-thiadiazoles as Inhibitors of TNF-alpha: Pharmacophore Hybridization for Treatment of Neuropathic Pain
por: Sharma, Monika, et al.
Publicado: (2012)

Pyrazolo[4,3-c]pyridine Sulfonamides as Carbonic Anhydrase Inhibitors: Synthesis, Biological and In Silico Studies
por: Angeli, Andrea, et al.
Publicado: (2022)

Synthesis, Biological and In Silico Studies of Griseofulvin and Usnic Acid Sulfonamide Derivatives as Fungal, Bacterial and Human Carbonic Anhydrase Inhibitors
por: Angeli, Andrea, et al.
Publicado: (2023)

Developing New Treatments for COVID-19 through Dual-Action Antiviral/Anti-Inflammatory Small Molecules and Physiologically Based Pharmacokinetic Modeling
por: Zagaliotis, Panagiotis, et al.
Publicado: (2022)

Vitamin A Update: Forms, Sources, Kinetics, Detection, Function, Deficiency, Therapeutic Use and Toxicity
por: Carazo, Alejandro, et al.
Publicado: (2021)

Development of Novel Triazolo-Thiadiazoles from Heterogeneous “Green” Catalysis as Protein Tyrosine Phosphatase 1B Inhibitors
por: Baburajeev, C. P., et al.
Publicado: (2015)

Analysis of Tonsil Tissues from Patients Diagnosed with Chronic Tonsillitis—Microbiological Profile, Biofilm-Forming Capacity and Histology
por: Kostić, Marina, et al.
Publicado: (2022)

Synthesis and Biological Activity of 3-(2-Furanyl)-6-Aryl-1,2,4-Triazolo[3,4-b]-1,3,4 –Thiadiazoles
por: Zhang, Li-Xue, et al.
Publicado: (2002)

Extending the Inhibition Profiles of Coumarin-Based Compounds Against Human Carbonic Anhydrases: Synthesis, Biological, and In Silico Evaluation
por: Kartsev, Victor, et al.
Publicado: (2019)

Carbonic Anhydrase Inhibition with Sulfonamides Incorporating Pyrazole- and Pyridazinecarboxamide Moieties Provides Examples of Isoform-Selective Inhibitors
por: Angeli, Andrea, et al.
Publicado: (2021)

Chromene-Containing Aromatic Sulfonamides with Carbonic Anhydrase Inhibitory Properties
por: Angeli, Andrea, et al.
Publicado: (2021)

Application of Docking Analysis in the Prediction and Biological Evaluation of the Lipoxygenase Inhibitory Action of Thiazolyl Derivatives of Mycophenolic Acid
por: Tsolaki, Evangelia, et al.
Publicado: (2018)

A Comparative Study of Lactarius Mushrooms: Chemical Characterization, Antibacterial, Antibiofilm, Antioxidant and Cytotoxic Activity
por: Kostić, Marina, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_nblel77juhv0c32ocrdqnqikt2