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Evaluation of the Clinical Use of Ceftriaxone among In-Patients in Selected Health Facilities in Uganda

Ceftriaxone has a high propensity for misuse because of its high rate of utilization. In this study, we aimed at assessing the appropriateness of the clinical utilization of ceftriaxone in nine health facilities in Uganda. Using the World Health Organization (WHO) Drug Use Evaluation indicators, we...

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Autores principales: Kutyabami, Paul, Munanura, Edson Ireeta, Kalidi, Rajab, Balikuna, Sulah, Ndagire, Margaret, Kaggwa, Bruhan, Nambatya, Winnie, Kamba, Pakoyo Fadhiru, Musiimenta, Allan, Kesi, Diana Nakitto, Nambasa, Victoria, Serwanga, Allan, Ndagije, Helen Byomire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300672/
https://www.ncbi.nlm.nih.gov/pubmed/34202391
http://dx.doi.org/10.3390/antibiotics10070779
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author Kutyabami, Paul
Munanura, Edson Ireeta
Kalidi, Rajab
Balikuna, Sulah
Ndagire, Margaret
Kaggwa, Bruhan
Nambatya, Winnie
Kamba, Pakoyo Fadhiru
Musiimenta, Allan
Kesi, Diana Nakitto
Nambasa, Victoria
Serwanga, Allan
Ndagije, Helen Byomire
author_facet Kutyabami, Paul
Munanura, Edson Ireeta
Kalidi, Rajab
Balikuna, Sulah
Ndagire, Margaret
Kaggwa, Bruhan
Nambatya, Winnie
Kamba, Pakoyo Fadhiru
Musiimenta, Allan
Kesi, Diana Nakitto
Nambasa, Victoria
Serwanga, Allan
Ndagije, Helen Byomire
author_sort Kutyabami, Paul
collection PubMed
description Ceftriaxone has a high propensity for misuse because of its high rate of utilization. In this study, we aimed at assessing the appropriateness of the clinical utilization of ceftriaxone in nine health facilities in Uganda. Using the World Health Organization (WHO) Drug Use Evaluation indicators, we reviewed a systematic sample of 885 patients’ treatment records selected over a three (3)-month period. Our results showed that prescriptions were written mostly by medical officers at 53.3% (470/882). Ceftriaxone was prescribed mainly for surgical prophylaxis at 25.3% (154/609), respiratory tract infections at 17% (104/609), and sepsis at 11% (67/609), as well as for non-recommended indications such as malaria at 7% (43/609) and anemia at 8% (49/609). Ceftriaxone was mostly prescribed once daily (92.3%; 817/885), as a 2 g dose (50.1%; 443/885), and for 5 days (41%; 363/885). The average score of inappropriate use of ceftriaxone in the eight indicators was 32.1%. Only 58.3% (516/885) of the ceftriaxone doses prescribed were administered to completion. Complete blood count and culture and sensitivity testing rates were 38.8% (343/885) and 1.13% (10/885), respectively. Over 85.4% (756/885) of the patients improved and were discharged. Factors associated with appropriate ceftriaxone use were gender, pregnancy status, days of hospitalization, health facility level of care, health facility type, and type of prescriber.
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spelling pubmed-83006722021-07-24 Evaluation of the Clinical Use of Ceftriaxone among In-Patients in Selected Health Facilities in Uganda Kutyabami, Paul Munanura, Edson Ireeta Kalidi, Rajab Balikuna, Sulah Ndagire, Margaret Kaggwa, Bruhan Nambatya, Winnie Kamba, Pakoyo Fadhiru Musiimenta, Allan Kesi, Diana Nakitto Nambasa, Victoria Serwanga, Allan Ndagije, Helen Byomire Antibiotics (Basel) Article Ceftriaxone has a high propensity for misuse because of its high rate of utilization. In this study, we aimed at assessing the appropriateness of the clinical utilization of ceftriaxone in nine health facilities in Uganda. Using the World Health Organization (WHO) Drug Use Evaluation indicators, we reviewed a systematic sample of 885 patients’ treatment records selected over a three (3)-month period. Our results showed that prescriptions were written mostly by medical officers at 53.3% (470/882). Ceftriaxone was prescribed mainly for surgical prophylaxis at 25.3% (154/609), respiratory tract infections at 17% (104/609), and sepsis at 11% (67/609), as well as for non-recommended indications such as malaria at 7% (43/609) and anemia at 8% (49/609). Ceftriaxone was mostly prescribed once daily (92.3%; 817/885), as a 2 g dose (50.1%; 443/885), and for 5 days (41%; 363/885). The average score of inappropriate use of ceftriaxone in the eight indicators was 32.1%. Only 58.3% (516/885) of the ceftriaxone doses prescribed were administered to completion. Complete blood count and culture and sensitivity testing rates were 38.8% (343/885) and 1.13% (10/885), respectively. Over 85.4% (756/885) of the patients improved and were discharged. Factors associated with appropriate ceftriaxone use were gender, pregnancy status, days of hospitalization, health facility level of care, health facility type, and type of prescriber. MDPI 2021-06-25 /pmc/articles/PMC8300672/ /pubmed/34202391 http://dx.doi.org/10.3390/antibiotics10070779 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kutyabami, Paul
Munanura, Edson Ireeta
Kalidi, Rajab
Balikuna, Sulah
Ndagire, Margaret
Kaggwa, Bruhan
Nambatya, Winnie
Kamba, Pakoyo Fadhiru
Musiimenta, Allan
Kesi, Diana Nakitto
Nambasa, Victoria
Serwanga, Allan
Ndagije, Helen Byomire
Evaluation of the Clinical Use of Ceftriaxone among In-Patients in Selected Health Facilities in Uganda
title Evaluation of the Clinical Use of Ceftriaxone among In-Patients in Selected Health Facilities in Uganda
title_full Evaluation of the Clinical Use of Ceftriaxone among In-Patients in Selected Health Facilities in Uganda
title_fullStr Evaluation of the Clinical Use of Ceftriaxone among In-Patients in Selected Health Facilities in Uganda
title_full_unstemmed Evaluation of the Clinical Use of Ceftriaxone among In-Patients in Selected Health Facilities in Uganda
title_short Evaluation of the Clinical Use of Ceftriaxone among In-Patients in Selected Health Facilities in Uganda
title_sort evaluation of the clinical use of ceftriaxone among in-patients in selected health facilities in uganda
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300672/
https://www.ncbi.nlm.nih.gov/pubmed/34202391
http://dx.doi.org/10.3390/antibiotics10070779
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