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Therapeutic Potential of α-Crystallins in Retinal Neurodegenerative Diseases

The chaperone and anti-apoptotic activity of α-crystallins (αA- and αB-) and their derivatives has received increasing attention due to their tremendous potential in preventing cell death. While originally known and described for their role in the lens, the upregulation of these proteins in cells an...

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Autores principales: Phadte, Ashutosh S., Sluzala, Zachary B., Fort, Patrice E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300683/
https://www.ncbi.nlm.nih.gov/pubmed/34201535
http://dx.doi.org/10.3390/antiox10071001
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author Phadte, Ashutosh S.
Sluzala, Zachary B.
Fort, Patrice E.
author_facet Phadte, Ashutosh S.
Sluzala, Zachary B.
Fort, Patrice E.
author_sort Phadte, Ashutosh S.
collection PubMed
description The chaperone and anti-apoptotic activity of α-crystallins (αA- and αB-) and their derivatives has received increasing attention due to their tremendous potential in preventing cell death. While originally known and described for their role in the lens, the upregulation of these proteins in cells and animal models of neurodegenerative diseases highlighted their involvement in adaptive protective responses to neurodegeneration associated stress. However, several studies also suggest that chronic neurodegenerative conditions are associated with progressive loss of function of these proteins. Thus, while external supplementation of α-crystallin shows promise, their potential as a protein-based therapeutic for the treatment of chronic neurodegenerative diseases remains ambiguous. The current review aims at assessing the current literature supporting the anti-apoptotic potential of αA- and αB-crystallins and its potential involvement in retinal neurodegenerative diseases. The review further extends into potentially modulating the chaperone and the anti-apoptotic function of α-crystallins and the use of such functionally enhanced proteins for promoting neuronal viability in retinal neurodegenerative disease.
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spelling pubmed-83006832021-07-24 Therapeutic Potential of α-Crystallins in Retinal Neurodegenerative Diseases Phadte, Ashutosh S. Sluzala, Zachary B. Fort, Patrice E. Antioxidants (Basel) Review The chaperone and anti-apoptotic activity of α-crystallins (αA- and αB-) and their derivatives has received increasing attention due to their tremendous potential in preventing cell death. While originally known and described for their role in the lens, the upregulation of these proteins in cells and animal models of neurodegenerative diseases highlighted their involvement in adaptive protective responses to neurodegeneration associated stress. However, several studies also suggest that chronic neurodegenerative conditions are associated with progressive loss of function of these proteins. Thus, while external supplementation of α-crystallin shows promise, their potential as a protein-based therapeutic for the treatment of chronic neurodegenerative diseases remains ambiguous. The current review aims at assessing the current literature supporting the anti-apoptotic potential of αA- and αB-crystallins and its potential involvement in retinal neurodegenerative diseases. The review further extends into potentially modulating the chaperone and the anti-apoptotic function of α-crystallins and the use of such functionally enhanced proteins for promoting neuronal viability in retinal neurodegenerative disease. MDPI 2021-06-23 /pmc/articles/PMC8300683/ /pubmed/34201535 http://dx.doi.org/10.3390/antiox10071001 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Phadte, Ashutosh S.
Sluzala, Zachary B.
Fort, Patrice E.
Therapeutic Potential of α-Crystallins in Retinal Neurodegenerative Diseases
title Therapeutic Potential of α-Crystallins in Retinal Neurodegenerative Diseases
title_full Therapeutic Potential of α-Crystallins in Retinal Neurodegenerative Diseases
title_fullStr Therapeutic Potential of α-Crystallins in Retinal Neurodegenerative Diseases
title_full_unstemmed Therapeutic Potential of α-Crystallins in Retinal Neurodegenerative Diseases
title_short Therapeutic Potential of α-Crystallins in Retinal Neurodegenerative Diseases
title_sort therapeutic potential of α-crystallins in retinal neurodegenerative diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300683/
https://www.ncbi.nlm.nih.gov/pubmed/34201535
http://dx.doi.org/10.3390/antiox10071001
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