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Potential Impact of the Involvement of Clinical Pharmacists in Antimicrobial Stewardship Programs on the Incidence of Antimicrobial-Related Adverse Events in Hospitalized Patients: A Multicenter Retrospective Study

Although specialized pharmacists have been suggested to be essential members of antimicrobial stewardship programs (ASPs), not all hospitals in Korea operate ASPs with pharmacists involved. We aimed to evaluate the association of involvement of clinical pharmacists as team members of multidisciplina...

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Autores principales: Suh, Yewon, Ah, Young-Mi, Chun, Ha-Jin, Lee, Su-Mi, Kim, Hyung-sook, Gu, Hyun-Jun, Kim, A-Jeong, Chung, Jee-Eun, Cho, Yoonsook, Lee, Young-Hee, Hwangbo, Shin-Yi, Kim, Jeongmee, Kim, Eu-Suk, Kim, Hong-Bin, Lee, Eunsook, Lee, Ju-Yeun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300750/
https://www.ncbi.nlm.nih.gov/pubmed/34356774
http://dx.doi.org/10.3390/antibiotics10070853
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author Suh, Yewon
Ah, Young-Mi
Chun, Ha-Jin
Lee, Su-Mi
Kim, Hyung-sook
Gu, Hyun-Jun
Kim, A-Jeong
Chung, Jee-Eun
Cho, Yoonsook
Lee, Young-Hee
Hwangbo, Shin-Yi
Kim, Jeongmee
Kim, Eu-Suk
Kim, Hong-Bin
Lee, Eunsook
Lee, Ju-Yeun
author_facet Suh, Yewon
Ah, Young-Mi
Chun, Ha-Jin
Lee, Su-Mi
Kim, Hyung-sook
Gu, Hyun-Jun
Kim, A-Jeong
Chung, Jee-Eun
Cho, Yoonsook
Lee, Young-Hee
Hwangbo, Shin-Yi
Kim, Jeongmee
Kim, Eu-Suk
Kim, Hong-Bin
Lee, Eunsook
Lee, Ju-Yeun
author_sort Suh, Yewon
collection PubMed
description Although specialized pharmacists have been suggested to be essential members of antimicrobial stewardship programs (ASPs), not all hospitals in Korea operate ASPs with pharmacists involved. We aimed to evaluate the association of involvement of clinical pharmacists as team members of multidisciplinary ASPs with the incidence of antimicrobial-related adverse drug events (ADEs). Five tertiary teaching hospitals participated in this retrospective cohort study. At each participating hospital, we randomly selected 1000 participants among patients who had received systemic antimicrobial agents for more than one day during the first quarter of 2017. We investigated five categories of antimicrobial-related ADEs: allergic reactions, hematologic toxicity, nephrotoxicity, hepatotoxicity, and antimicrobial-related diarrhea. Multivariate logistic regression analysis was used to evaluate the potential impact of pharmacist involvement in ASPs on the incidence of ADEs. A total of 1195 antimicrobial-related ADEs occurred in 618 (12.4%) of the 4995 patients included in the analysis. The overall rate of ADE occurrence was 17.4 per 1000 patient days. Hospitals operating ASPs with pharmacists showed significantly lower AE incidence proportions than other hospitals (8.9% vs. 14.7%; p < 0.001). Multidisciplinary ASPs that included clinical pharmacists reduced the risk of antimicrobial-related ADEs by 38% (adjusted odds ratio 0.62; 95% confidence interval 0.50–0.77). Our results suggest that the active involvement of clinical pharmacists in multidisciplinary ASPs may contribute to reduce the incidence of antimicrobial-related ADEs in hospitalized patients.
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spelling pubmed-83007502021-07-24 Potential Impact of the Involvement of Clinical Pharmacists in Antimicrobial Stewardship Programs on the Incidence of Antimicrobial-Related Adverse Events in Hospitalized Patients: A Multicenter Retrospective Study Suh, Yewon Ah, Young-Mi Chun, Ha-Jin Lee, Su-Mi Kim, Hyung-sook Gu, Hyun-Jun Kim, A-Jeong Chung, Jee-Eun Cho, Yoonsook Lee, Young-Hee Hwangbo, Shin-Yi Kim, Jeongmee Kim, Eu-Suk Kim, Hong-Bin Lee, Eunsook Lee, Ju-Yeun Antibiotics (Basel) Article Although specialized pharmacists have been suggested to be essential members of antimicrobial stewardship programs (ASPs), not all hospitals in Korea operate ASPs with pharmacists involved. We aimed to evaluate the association of involvement of clinical pharmacists as team members of multidisciplinary ASPs with the incidence of antimicrobial-related adverse drug events (ADEs). Five tertiary teaching hospitals participated in this retrospective cohort study. At each participating hospital, we randomly selected 1000 participants among patients who had received systemic antimicrobial agents for more than one day during the first quarter of 2017. We investigated five categories of antimicrobial-related ADEs: allergic reactions, hematologic toxicity, nephrotoxicity, hepatotoxicity, and antimicrobial-related diarrhea. Multivariate logistic regression analysis was used to evaluate the potential impact of pharmacist involvement in ASPs on the incidence of ADEs. A total of 1195 antimicrobial-related ADEs occurred in 618 (12.4%) of the 4995 patients included in the analysis. The overall rate of ADE occurrence was 17.4 per 1000 patient days. Hospitals operating ASPs with pharmacists showed significantly lower AE incidence proportions than other hospitals (8.9% vs. 14.7%; p < 0.001). Multidisciplinary ASPs that included clinical pharmacists reduced the risk of antimicrobial-related ADEs by 38% (adjusted odds ratio 0.62; 95% confidence interval 0.50–0.77). Our results suggest that the active involvement of clinical pharmacists in multidisciplinary ASPs may contribute to reduce the incidence of antimicrobial-related ADEs in hospitalized patients. MDPI 2021-07-14 /pmc/articles/PMC8300750/ /pubmed/34356774 http://dx.doi.org/10.3390/antibiotics10070853 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Suh, Yewon
Ah, Young-Mi
Chun, Ha-Jin
Lee, Su-Mi
Kim, Hyung-sook
Gu, Hyun-Jun
Kim, A-Jeong
Chung, Jee-Eun
Cho, Yoonsook
Lee, Young-Hee
Hwangbo, Shin-Yi
Kim, Jeongmee
Kim, Eu-Suk
Kim, Hong-Bin
Lee, Eunsook
Lee, Ju-Yeun
Potential Impact of the Involvement of Clinical Pharmacists in Antimicrobial Stewardship Programs on the Incidence of Antimicrobial-Related Adverse Events in Hospitalized Patients: A Multicenter Retrospective Study
title Potential Impact of the Involvement of Clinical Pharmacists in Antimicrobial Stewardship Programs on the Incidence of Antimicrobial-Related Adverse Events in Hospitalized Patients: A Multicenter Retrospective Study
title_full Potential Impact of the Involvement of Clinical Pharmacists in Antimicrobial Stewardship Programs on the Incidence of Antimicrobial-Related Adverse Events in Hospitalized Patients: A Multicenter Retrospective Study
title_fullStr Potential Impact of the Involvement of Clinical Pharmacists in Antimicrobial Stewardship Programs on the Incidence of Antimicrobial-Related Adverse Events in Hospitalized Patients: A Multicenter Retrospective Study
title_full_unstemmed Potential Impact of the Involvement of Clinical Pharmacists in Antimicrobial Stewardship Programs on the Incidence of Antimicrobial-Related Adverse Events in Hospitalized Patients: A Multicenter Retrospective Study
title_short Potential Impact of the Involvement of Clinical Pharmacists in Antimicrobial Stewardship Programs on the Incidence of Antimicrobial-Related Adverse Events in Hospitalized Patients: A Multicenter Retrospective Study
title_sort potential impact of the involvement of clinical pharmacists in antimicrobial stewardship programs on the incidence of antimicrobial-related adverse events in hospitalized patients: a multicenter retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300750/
https://www.ncbi.nlm.nih.gov/pubmed/34356774
http://dx.doi.org/10.3390/antibiotics10070853
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