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Comparative Analysis of Felixounavirus Genomes Including Two New Members of the Genus That Infect Salmonella Infantis

Salmonella spp. is one of the most common foodborne pathogens worldwide; therefore, its control is highly relevant for the food industry. Phages of the Felixounavirus genus have the characteristic that one phage can infect a large number of different Salmonella serovars and, thus, are proposed as an...

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Autores principales: Barron-Montenegro, Rocío, García, Rodrigo, Dueñas, Fernando, Rivera, Dácil, Opazo-Capurro, Andrés, Erickson, Stephen, Moreno-Switt, Andrea I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300805/
https://www.ncbi.nlm.nih.gov/pubmed/34356727
http://dx.doi.org/10.3390/antibiotics10070806
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author Barron-Montenegro, Rocío
García, Rodrigo
Dueñas, Fernando
Rivera, Dácil
Opazo-Capurro, Andrés
Erickson, Stephen
Moreno-Switt, Andrea I
author_facet Barron-Montenegro, Rocío
García, Rodrigo
Dueñas, Fernando
Rivera, Dácil
Opazo-Capurro, Andrés
Erickson, Stephen
Moreno-Switt, Andrea I
author_sort Barron-Montenegro, Rocío
collection PubMed
description Salmonella spp. is one of the most common foodborne pathogens worldwide; therefore, its control is highly relevant for the food industry. Phages of the Felixounavirus genus have the characteristic that one phage can infect a large number of different Salmonella serovars and, thus, are proposed as an alternative to antimicrobials in food production. Here, we describe two new members of the Felixounavirus genus named vB_Si_35FD and vB_Si_DR94, which can infect Salmonella Infantis. These new members were isolated and sequenced, and a subsequent comparative genomic analysis was conducted including 23 publicly available genomes of Felixounaviruses that infect Salmonella. The genomes of vB_Si_35FD and vB_Si_DR94 are 85,818 and 85,730 bp large and contain 129 and 125 coding sequences, respectively. The genomes did not show genes associated with virulence or antimicrobial resistance, which could be useful for candidates to use as biocontrol agents. Comparative genomics revealed that closely related Felixounavirus are found in distinct geographical locations and that this genus has a conserved genomic structure despite its worldwide distribution. Our study revealed a highly conserved structure of the phage genomes, and the two newly described phages could represent promising biocontrol candidates against Salmonella spp. from a genomic viewpoint.
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spelling pubmed-83008052021-07-24 Comparative Analysis of Felixounavirus Genomes Including Two New Members of the Genus That Infect Salmonella Infantis Barron-Montenegro, Rocío García, Rodrigo Dueñas, Fernando Rivera, Dácil Opazo-Capurro, Andrés Erickson, Stephen Moreno-Switt, Andrea I Antibiotics (Basel) Article Salmonella spp. is one of the most common foodborne pathogens worldwide; therefore, its control is highly relevant for the food industry. Phages of the Felixounavirus genus have the characteristic that one phage can infect a large number of different Salmonella serovars and, thus, are proposed as an alternative to antimicrobials in food production. Here, we describe two new members of the Felixounavirus genus named vB_Si_35FD and vB_Si_DR94, which can infect Salmonella Infantis. These new members were isolated and sequenced, and a subsequent comparative genomic analysis was conducted including 23 publicly available genomes of Felixounaviruses that infect Salmonella. The genomes of vB_Si_35FD and vB_Si_DR94 are 85,818 and 85,730 bp large and contain 129 and 125 coding sequences, respectively. The genomes did not show genes associated with virulence or antimicrobial resistance, which could be useful for candidates to use as biocontrol agents. Comparative genomics revealed that closely related Felixounavirus are found in distinct geographical locations and that this genus has a conserved genomic structure despite its worldwide distribution. Our study revealed a highly conserved structure of the phage genomes, and the two newly described phages could represent promising biocontrol candidates against Salmonella spp. from a genomic viewpoint. MDPI 2021-07-02 /pmc/articles/PMC8300805/ /pubmed/34356727 http://dx.doi.org/10.3390/antibiotics10070806 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Barron-Montenegro, Rocío
García, Rodrigo
Dueñas, Fernando
Rivera, Dácil
Opazo-Capurro, Andrés
Erickson, Stephen
Moreno-Switt, Andrea I
Comparative Analysis of Felixounavirus Genomes Including Two New Members of the Genus That Infect Salmonella Infantis
title Comparative Analysis of Felixounavirus Genomes Including Two New Members of the Genus That Infect Salmonella Infantis
title_full Comparative Analysis of Felixounavirus Genomes Including Two New Members of the Genus That Infect Salmonella Infantis
title_fullStr Comparative Analysis of Felixounavirus Genomes Including Two New Members of the Genus That Infect Salmonella Infantis
title_full_unstemmed Comparative Analysis of Felixounavirus Genomes Including Two New Members of the Genus That Infect Salmonella Infantis
title_short Comparative Analysis of Felixounavirus Genomes Including Two New Members of the Genus That Infect Salmonella Infantis
title_sort comparative analysis of felixounavirus genomes including two new members of the genus that infect salmonella infantis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300805/
https://www.ncbi.nlm.nih.gov/pubmed/34356727
http://dx.doi.org/10.3390/antibiotics10070806
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