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Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling

Rescue of cognitive function represents an unmet need in the treatment of neurodegenerative disorders such as Alzheimer’s disease (AD). Nutraceuticals deliver a concentrated form of a presumed bioactive(s) agent(s) that can improve cognitive function alone or in combination with current approved dru...

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Autores principales: Grasso, Margherita, Caruso, Giuseppe, Godos, Justyna, Bonaccorso, Angela, Carbone, Claudia, Castellano, Sabrina, Currenti, Walter, Grosso, Giuseppe, Musumeci, Teresa, Caraci, Filippo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301008/
https://www.ncbi.nlm.nih.gov/pubmed/34356309
http://dx.doi.org/10.3390/antiox10071075
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author Grasso, Margherita
Caruso, Giuseppe
Godos, Justyna
Bonaccorso, Angela
Carbone, Claudia
Castellano, Sabrina
Currenti, Walter
Grosso, Giuseppe
Musumeci, Teresa
Caraci, Filippo
author_facet Grasso, Margherita
Caruso, Giuseppe
Godos, Justyna
Bonaccorso, Angela
Carbone, Claudia
Castellano, Sabrina
Currenti, Walter
Grosso, Giuseppe
Musumeci, Teresa
Caraci, Filippo
author_sort Grasso, Margherita
collection PubMed
description Rescue of cognitive function represents an unmet need in the treatment of neurodegenerative disorders such as Alzheimer’s disease (AD). Nutraceuticals deliver a concentrated form of a presumed bioactive(s) agent(s) that can improve cognitive function alone or in combination with current approved drugs for the treatment of cognitive disorders. Nutraceuticals include different natural compounds such as flavonoids and their subclasses (flavan-3-ols, catechins, anthocyanins, and flavonols), omega-3, and carnosine that can improve synaptic plasticity and rescue cognitive deficits through multiple molecular mechanisms. A deficit of transforming growth factor-β1 (TGF-β1) pathway is an early event in the pathophysiology of cognitive impairment in different neuropsychiatric disorders, from depression to AD. In the present review, we provide evidence that different nutraceuticals, such as Hypericum perforatum (hypericin and hyperforin), flavonoids such as hesperidin, omega-3, and carnosine, can target TGF-β1 signaling and increase TGF-β1 production in the central nervous system as well as cognitive function. The bioavailability of these nutraceuticals, in particular carnosine, can be significantly improved with novel formulations (nanoparticulate systems, nanoliposomes) that increase the efficacy and stability of this peptide. Overall, these studies suggest that the synergism between nutraceuticals targeting the TGF-β1 pathway and current approved drugs might represent a novel pharmacological approach for reverting cognitive deficits in AD patients.
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spelling pubmed-83010082021-07-24 Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling Grasso, Margherita Caruso, Giuseppe Godos, Justyna Bonaccorso, Angela Carbone, Claudia Castellano, Sabrina Currenti, Walter Grosso, Giuseppe Musumeci, Teresa Caraci, Filippo Antioxidants (Basel) Review Rescue of cognitive function represents an unmet need in the treatment of neurodegenerative disorders such as Alzheimer’s disease (AD). Nutraceuticals deliver a concentrated form of a presumed bioactive(s) agent(s) that can improve cognitive function alone or in combination with current approved drugs for the treatment of cognitive disorders. Nutraceuticals include different natural compounds such as flavonoids and their subclasses (flavan-3-ols, catechins, anthocyanins, and flavonols), omega-3, and carnosine that can improve synaptic plasticity and rescue cognitive deficits through multiple molecular mechanisms. A deficit of transforming growth factor-β1 (TGF-β1) pathway is an early event in the pathophysiology of cognitive impairment in different neuropsychiatric disorders, from depression to AD. In the present review, we provide evidence that different nutraceuticals, such as Hypericum perforatum (hypericin and hyperforin), flavonoids such as hesperidin, omega-3, and carnosine, can target TGF-β1 signaling and increase TGF-β1 production in the central nervous system as well as cognitive function. The bioavailability of these nutraceuticals, in particular carnosine, can be significantly improved with novel formulations (nanoparticulate systems, nanoliposomes) that increase the efficacy and stability of this peptide. Overall, these studies suggest that the synergism between nutraceuticals targeting the TGF-β1 pathway and current approved drugs might represent a novel pharmacological approach for reverting cognitive deficits in AD patients. MDPI 2021-07-05 /pmc/articles/PMC8301008/ /pubmed/34356309 http://dx.doi.org/10.3390/antiox10071075 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Grasso, Margherita
Caruso, Giuseppe
Godos, Justyna
Bonaccorso, Angela
Carbone, Claudia
Castellano, Sabrina
Currenti, Walter
Grosso, Giuseppe
Musumeci, Teresa
Caraci, Filippo
Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling
title Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling
title_full Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling
title_fullStr Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling
title_full_unstemmed Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling
title_short Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling
title_sort improving cognition with nutraceuticals targeting tgf-β1 signaling
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301008/
https://www.ncbi.nlm.nih.gov/pubmed/34356309
http://dx.doi.org/10.3390/antiox10071075
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