Cargando…
Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling
Rescue of cognitive function represents an unmet need in the treatment of neurodegenerative disorders such as Alzheimer’s disease (AD). Nutraceuticals deliver a concentrated form of a presumed bioactive(s) agent(s) that can improve cognitive function alone or in combination with current approved dru...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301008/ https://www.ncbi.nlm.nih.gov/pubmed/34356309 http://dx.doi.org/10.3390/antiox10071075 |
_version_ | 1783726572075745280 |
---|---|
author | Grasso, Margherita Caruso, Giuseppe Godos, Justyna Bonaccorso, Angela Carbone, Claudia Castellano, Sabrina Currenti, Walter Grosso, Giuseppe Musumeci, Teresa Caraci, Filippo |
author_facet | Grasso, Margherita Caruso, Giuseppe Godos, Justyna Bonaccorso, Angela Carbone, Claudia Castellano, Sabrina Currenti, Walter Grosso, Giuseppe Musumeci, Teresa Caraci, Filippo |
author_sort | Grasso, Margherita |
collection | PubMed |
description | Rescue of cognitive function represents an unmet need in the treatment of neurodegenerative disorders such as Alzheimer’s disease (AD). Nutraceuticals deliver a concentrated form of a presumed bioactive(s) agent(s) that can improve cognitive function alone or in combination with current approved drugs for the treatment of cognitive disorders. Nutraceuticals include different natural compounds such as flavonoids and their subclasses (flavan-3-ols, catechins, anthocyanins, and flavonols), omega-3, and carnosine that can improve synaptic plasticity and rescue cognitive deficits through multiple molecular mechanisms. A deficit of transforming growth factor-β1 (TGF-β1) pathway is an early event in the pathophysiology of cognitive impairment in different neuropsychiatric disorders, from depression to AD. In the present review, we provide evidence that different nutraceuticals, such as Hypericum perforatum (hypericin and hyperforin), flavonoids such as hesperidin, omega-3, and carnosine, can target TGF-β1 signaling and increase TGF-β1 production in the central nervous system as well as cognitive function. The bioavailability of these nutraceuticals, in particular carnosine, can be significantly improved with novel formulations (nanoparticulate systems, nanoliposomes) that increase the efficacy and stability of this peptide. Overall, these studies suggest that the synergism between nutraceuticals targeting the TGF-β1 pathway and current approved drugs might represent a novel pharmacological approach for reverting cognitive deficits in AD patients. |
format | Online Article Text |
id | pubmed-8301008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83010082021-07-24 Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling Grasso, Margherita Caruso, Giuseppe Godos, Justyna Bonaccorso, Angela Carbone, Claudia Castellano, Sabrina Currenti, Walter Grosso, Giuseppe Musumeci, Teresa Caraci, Filippo Antioxidants (Basel) Review Rescue of cognitive function represents an unmet need in the treatment of neurodegenerative disorders such as Alzheimer’s disease (AD). Nutraceuticals deliver a concentrated form of a presumed bioactive(s) agent(s) that can improve cognitive function alone or in combination with current approved drugs for the treatment of cognitive disorders. Nutraceuticals include different natural compounds such as flavonoids and their subclasses (flavan-3-ols, catechins, anthocyanins, and flavonols), omega-3, and carnosine that can improve synaptic plasticity and rescue cognitive deficits through multiple molecular mechanisms. A deficit of transforming growth factor-β1 (TGF-β1) pathway is an early event in the pathophysiology of cognitive impairment in different neuropsychiatric disorders, from depression to AD. In the present review, we provide evidence that different nutraceuticals, such as Hypericum perforatum (hypericin and hyperforin), flavonoids such as hesperidin, omega-3, and carnosine, can target TGF-β1 signaling and increase TGF-β1 production in the central nervous system as well as cognitive function. The bioavailability of these nutraceuticals, in particular carnosine, can be significantly improved with novel formulations (nanoparticulate systems, nanoliposomes) that increase the efficacy and stability of this peptide. Overall, these studies suggest that the synergism between nutraceuticals targeting the TGF-β1 pathway and current approved drugs might represent a novel pharmacological approach for reverting cognitive deficits in AD patients. MDPI 2021-07-05 /pmc/articles/PMC8301008/ /pubmed/34356309 http://dx.doi.org/10.3390/antiox10071075 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Grasso, Margherita Caruso, Giuseppe Godos, Justyna Bonaccorso, Angela Carbone, Claudia Castellano, Sabrina Currenti, Walter Grosso, Giuseppe Musumeci, Teresa Caraci, Filippo Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling |
title | Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling |
title_full | Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling |
title_fullStr | Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling |
title_full_unstemmed | Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling |
title_short | Improving Cognition with Nutraceuticals Targeting TGF-β1 Signaling |
title_sort | improving cognition with nutraceuticals targeting tgf-β1 signaling |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301008/ https://www.ncbi.nlm.nih.gov/pubmed/34356309 http://dx.doi.org/10.3390/antiox10071075 |
work_keys_str_mv | AT grassomargherita improvingcognitionwithnutraceuticalstargetingtgfb1signaling AT carusogiuseppe improvingcognitionwithnutraceuticalstargetingtgfb1signaling AT godosjustyna improvingcognitionwithnutraceuticalstargetingtgfb1signaling AT bonaccorsoangela improvingcognitionwithnutraceuticalstargetingtgfb1signaling AT carboneclaudia improvingcognitionwithnutraceuticalstargetingtgfb1signaling AT castellanosabrina improvingcognitionwithnutraceuticalstargetingtgfb1signaling AT currentiwalter improvingcognitionwithnutraceuticalstargetingtgfb1signaling AT grossogiuseppe improvingcognitionwithnutraceuticalstargetingtgfb1signaling AT musumeciteresa improvingcognitionwithnutraceuticalstargetingtgfb1signaling AT caracifilippo improvingcognitionwithnutraceuticalstargetingtgfb1signaling |