Human Trisomic iPSCs from Down Syndrome Fibroblasts Manifest Mitochondrial Alterations Early during Neuronal Differentiation

SIMPLE SUMMARY: Down Syndrome, which is due to the presence of three copies of chromosome 21, always presents with mental retardation, possibly caused by defects in the development of neurons. In recent years, it has been shown that cells and tissues in Down syndrome manifest alterations in the func...

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Detalles Bibliográficos
Autores principales: Mollo, Nunzia, Esposito, Matteo, Aurilia, Miriam, Scognamiglio, Roberta, Accarino, Rossella, Bonfiglio, Ferdinando, Cicatiello, Rita, Charalambous, Maria, Procaccini, Claudio, Micillo, Teresa, Genesio, Rita, Calì, Gaetano, Secondo, Agnese, Paladino, Simona, Matarese, Giuseppe, Vita, Gabriella De, Conti, Anna, Nitsch, Lucio, Izzo, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301075/
https://www.ncbi.nlm.nih.gov/pubmed/34209429
http://dx.doi.org/10.3390/biology10070609

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