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The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy

Viral infections constitute a tectonic convulsion in the normophysiology of the hosts. The current coronavirus disease 2019 (COVID-19) pandemic is not an exception, and therefore the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, like any other invading microbe, enacts a gen...

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Autores principales: Ramos, Eva, López-Muñoz, Francisco, Gil-Martín, Emilio, Egea, Javier, Álvarez-Merz, Iris, Painuli, Sakshi, Semwal, Prabhakar, Martins, Natália, Hernández-Guijo, Jesús M., Romero, Alejandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301107/
https://www.ncbi.nlm.nih.gov/pubmed/34356384
http://dx.doi.org/10.3390/antiox10071152
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author Ramos, Eva
López-Muñoz, Francisco
Gil-Martín, Emilio
Egea, Javier
Álvarez-Merz, Iris
Painuli, Sakshi
Semwal, Prabhakar
Martins, Natália
Hernández-Guijo, Jesús M.
Romero, Alejandro
author_facet Ramos, Eva
López-Muñoz, Francisco
Gil-Martín, Emilio
Egea, Javier
Álvarez-Merz, Iris
Painuli, Sakshi
Semwal, Prabhakar
Martins, Natália
Hernández-Guijo, Jesús M.
Romero, Alejandro
author_sort Ramos, Eva
collection PubMed
description Viral infections constitute a tectonic convulsion in the normophysiology of the hosts. The current coronavirus disease 2019 (COVID-19) pandemic is not an exception, and therefore the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, like any other invading microbe, enacts a generalized immune response once the virus contacts the body. Melatonin is a systemic dealer that does not overlook any homeostasis disturbance, which consequently brings into play its cooperative triad, antioxidant, anti-inflammatory, and immune-stimulant backbone, to stop the infective cycle of SARS-CoV-2 or any other endogenous or exogenous threat. In COVID-19, the corporal propagation of SARS-CoV-2 involves an exacerbated oxidative activity and therefore the overproduction of great amounts of reactive oxygen and nitrogen species (RONS). The endorsement of melatonin as a possible protective agent against the current pandemic is indirectly supported by its widely demonstrated beneficial role in preclinical and clinical studies of other respiratory diseases. In addition, focusing the therapeutic action on strengthening the host protection responses in critical phases of the infective cycle makes it likely that multi-tasking melatonin will provide multi-protection, maintaining its efficacy against the virus variants that are already emerging and will emerge as long as SARS-CoV-2 continues to circulate among us.
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spelling pubmed-83011072021-07-24 The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy Ramos, Eva López-Muñoz, Francisco Gil-Martín, Emilio Egea, Javier Álvarez-Merz, Iris Painuli, Sakshi Semwal, Prabhakar Martins, Natália Hernández-Guijo, Jesús M. Romero, Alejandro Antioxidants (Basel) Review Viral infections constitute a tectonic convulsion in the normophysiology of the hosts. The current coronavirus disease 2019 (COVID-19) pandemic is not an exception, and therefore the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, like any other invading microbe, enacts a generalized immune response once the virus contacts the body. Melatonin is a systemic dealer that does not overlook any homeostasis disturbance, which consequently brings into play its cooperative triad, antioxidant, anti-inflammatory, and immune-stimulant backbone, to stop the infective cycle of SARS-CoV-2 or any other endogenous or exogenous threat. In COVID-19, the corporal propagation of SARS-CoV-2 involves an exacerbated oxidative activity and therefore the overproduction of great amounts of reactive oxygen and nitrogen species (RONS). The endorsement of melatonin as a possible protective agent against the current pandemic is indirectly supported by its widely demonstrated beneficial role in preclinical and clinical studies of other respiratory diseases. In addition, focusing the therapeutic action on strengthening the host protection responses in critical phases of the infective cycle makes it likely that multi-tasking melatonin will provide multi-protection, maintaining its efficacy against the virus variants that are already emerging and will emerge as long as SARS-CoV-2 continues to circulate among us. MDPI 2021-07-20 /pmc/articles/PMC8301107/ /pubmed/34356384 http://dx.doi.org/10.3390/antiox10071152 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ramos, Eva
López-Muñoz, Francisco
Gil-Martín, Emilio
Egea, Javier
Álvarez-Merz, Iris
Painuli, Sakshi
Semwal, Prabhakar
Martins, Natália
Hernández-Guijo, Jesús M.
Romero, Alejandro
The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy
title The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy
title_full The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy
title_fullStr The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy
title_full_unstemmed The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy
title_short The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy
title_sort coronavirus disease 2019 (covid-19): key emphasis on melatonin safety and therapeutic efficacy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301107/
https://www.ncbi.nlm.nih.gov/pubmed/34356384
http://dx.doi.org/10.3390/antiox10071152
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