Cargando…

New Benzimidazothiazolone Derivatives as Tyrosinase Inhibitors with Potential Anti-Melanogenesis and Reactive Oxygen Species Scavenging Activities

Thirteen (Z)-2-(substituted benzylidene)benzimidazothiazolone analogs were synthesized and evaluated for their inhibitory activity against mushroom tyrosinase. Among the compounds synthesized, compounds 1–3 showed greater inhibitory activity than kojic acid (IC(50) = 18.27 ± 0.89 μM); IC(50) = 3.70...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jung, Hee Jin, Choi, Dong Chan, Noh, Sang Gyun, Choi, Heejeong, Choi, Inkyu, Ryu, Il Young, Chung, Hae Young, Moon, Hyung Ryong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301170/ https://www.ncbi.nlm.nih.gov/pubmed/34356311 http://dx.doi.org/10.3390/antiox10071078

Ejemplares similares

Urolithin and Reduced Urolithin Derivatives as Potent Inhibitors of Tyrosinase and Melanogenesis: Importance of the 4-Substituted Resorcinol Moiety
por: Lee, Sanggwon, et al.
Publicado: (2021)

(E)-1-(Furan-2-yl)-(substituted phenyl)prop-2-en-1-one Derivatives as Tyrosinase Inhibitors and Melanogenesis Inhibition: An In Vitro and In Silico Study
por: Jung, Hee Jin, et al.
Publicado: (2020)

In silico and in vitro insights into tyrosinase inhibitors with a 2-thioxooxazoline-4-one template
por: Choi, Inkyu, et al.
Publicado: (2020)

Identification of (Z)-2-benzylidene-dihydroimidazothiazolone derivatives as tyrosinase inhibitors: Anti-melanogenic effects and in silico studies
por: Choi, Heejeong, et al.
Publicado: (2022)

Identification of a Novel Class of Anti-Melanogenic Compounds, (Z)-5-(Substituted benzylidene)-3-phenyl-2-thioxothiazolidin-4-one Derivatives, and Their Reactive Oxygen Species Scavenging Activities
por: Jeong, Yeongmu, et al.
Publicado: (2022)

A Potent Tyrosinase Inhibitor, (E)-3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one, with Anti-Melanogenesis Properties in α-MSH and IBMX-Induced B16F10 Melanoma Cells
por: Kim, Chang Seok, et al.
Publicado: (2018)

In vitro and in silico insights into tyrosinase inhibitors with (E)-benzylidene-1-indanone derivatives
por: Jung, Hee Jin, et al.
Publicado: (2019)

Influence of plasma-activated compounds on melanogenesis and tyrosinase activity
por: Ali, Anser, et al.
Publicado: (2016)

Maclurin Exhibits Antioxidant and Anti-Tyrosinase Activities, Suppressing Melanogenesis
por: Moon, Kyoung Mi, et al.
Publicado: (2022)

Fermented Broth in Tyrosinase- and Melanogenesis Inhibition
por: Chan, Chin-Feng, et al.
Publicado: (2014)

Preventive effects of nano-graphene oxide against Parkinson’s disease via reactive oxygen species scavenging and anti-inflammation
por: Kim, Hee-Yeong, et al.
Publicado: (2023)

Tyrosinase Nanoparticles: Understanding the Melanogenesis Pathway by Isolating the Products of Tyrosinase Enzymatic Reaction
por: Varghese, Paul K., et al.
Publicado: (2021)

Tyrosinase-Targeting Gallacetophenone Inhibits Melanogenesis in Melanocytes and Human Skin- Equivalents
por: Lee, Ji Young, et al.
Publicado: (2020)

Upregulation of Melanogenesis and Tyrosinase Activity: Potential Agents for Vitiligo
por: Niu, Chao, et al.
Publicado: (2017)

Brassinin Abundant in Brassicaceae Suppresses Melanogenesis through Dual Mechanisms of Tyrosinase Inhibition
por: Lee, Min-Kyeong, et al.
Publicado: (2022)

Bamboo Lignin Fractions with In Vitro Tyrosinase Inhibition Activity Downregulate Melanogenesis in B16F10 Cells via PKA/CREB Signaling Pathway
por: Choi, Moon-Hee, et al.
Publicado: (2022)

Kinetics of Mushroom Tyrosinase and Melanogenesis Inhibition by N-Acetyl-pentapeptides
por: Lien, Ching-Yi, et al.
Publicado: (2014)

Inhibitory Effect of Curcumin-Inspired Derivatives on Tyrosinase Activity and Melanogenesis
por: Rocchitta, Gaia, et al.
Publicado: (2022)

Inhibitory Effect of Avenanthramides (Avn) on Tyrosinase Activity and Melanogenesis in α-MSH-Activated SK-MEL-2 Cells: In Vitro and In Silico Analysis
por: Park, Jun-Young, et al.
Publicado: (2021)

Natural Melanogenesis Inhibitors Acting Through the Down-Regulation of Tyrosinase Activity
por: Chang, Te-Sheng
Publicado: (2012)

Evaluation of the Novel Synthetic Tyrosinase Inhibitor (Z)-3-(3-bromo-4-hydroxybenzylidene)thiochroman-4-one (MHY1498) In Vitro and In Silico
por: Bang, EunJin, et al.
Publicado: (2018)

Melanogenesis-Inducing Effect of Cirsimaritin through Increases in Microphthalmia-Associated Transcription Factor and Tyrosinase Expression
por: Kim, Hyo Jung, et al.
Publicado: (2015)

Biochemistry of melanin synthesis: in vivo effects of MSH on tyrosinase and melanogenesis of pigmentary system.
por: Lee, T. H., et al.
Publicado: (1973)

Thioquinoline derivatives conjugated to thiosemicarbazide as potent tyrosinase inhibitors with anti-melanogenesis properties
por: Noori, Milad, et al.
Publicado: (2023)

Novel SIRT Inhibitor, MHY2256, Induces Cell Cycle Arrest, Apoptosis, and Autophagic Cell Death in HCT116 Human Colorectal Cancer Cells
por: Kim, Min Jeong, et al.
Publicado: (2020)

Antipathogenic Compounds That Are Effective at Very Low Concentrations and Have Both Antibiofilm and Antivirulence Effects against Pseudomonas aeruginosa
por: Hwang, Hyeon-Ji, et al.
Publicado: (2021)

The effect of Aspalathus linearis (Burm.f.) R.Dahlgren and its compounds on tyrosinase and melanogenesis
por: Blom van Staden, Analike, et al.
Publicado: (2021)

Molecular Docking, Synthesis, and Tyrosinase Inhibition Activity of Acetophenone Amide: Potential Inhibitor of Melanogenesis
por: Nazir, Yasir, et al.
Publicado: (2022)

IDO1 scavenges reactive oxygen species in myeloid-derived suppressor cells to prevent graft-versus-host disease
por: Ju, Ji-Min, et al.
Publicado: (2021)

Novel Anti-Melanogenic Compounds, (Z)-5-(Substituted Benzylidene)-4-thioxothiazolidin-2-one Derivatives: In Vitro and In Silico Insights
por: Choi, Heejeong, et al.
Publicado: (2021)

Auraptene Mitigates Parkinson’s Disease-Like Behavior by Protecting Inhibition of Mitochondrial Respiration and Scavenging Reactive Oxygen Species
por: Jang, Yunseon, et al.
Publicado: (2019)

Novel tyrosinase inhibitory peptide with free radical scavenging ability
por: Shen, Zhiwei, et al.
Publicado: (2019)

Aflatoxins are natural scavengers of reactive oxygen species
por: Finotti, E., et al.
Publicado: (2021)

Primary Cilia Negatively Regulate Melanogenesis in Melanocytes and Pigmentation in a Human Skin Model
por: Choi, Hyunjung, et al.
Publicado: (2016)

Plumbagin Suppresses α-MSH-Induced Melanogenesis in B16F10 Mouse Melanoma Cells by Inhibiting Tyrosinase Activity
por: Oh, Taek-In, et al.
Publicado: (2017)

(2E,5E)-2,5-Bis(3-hydroxy-4-methoxybenzylidene) cyclopentanone Exerts Anti-Melanogenesis and Anti-Wrinkle Activities in B16F10 Melanoma and Hs27 Fibroblast Cells
por: Jung, Hee Jin, et al.
Publicado: (2018)

Increased therapeutic efficacy of a newly synthesized tyrosinase inhibitor by solid lipid nanoparticles in the topical treatment of hyperpigmentation
por: Al-Amin, Md, et al.
Publicado: (2016)

5G Electromagnetic Radiation Attenuates Skin Melanogenesis In Vitro by Suppressing ROS Generation
por: Kim, Kyuri, et al.
Publicado: (2022)

The Potential of Minor Ginsenosides Isolated from the Leaves of Panax ginseng as Inhibitors of Melanogenesis
por: Lee, Dae-Young, et al.
Publicado: (2015)

Tyrosinase inhibitory components from Aloe vera and their antiviral activity
por: Kim, Jang Hoon, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_enagt1n1qvv4ahi8rrj3dqqcsj