Dual Mechanisms of Cardiac Action Potential Prolongation by 4-Oxo-Nonenal Increasing the Risk of Arrhythmia; Late Na(+) Current Induction and hERG K(+) Channel Inhibition

4-Oxo-nonenal (4-ONE) is an endogenous lipid peroxidation product that is more reactive than 4-hydroxy-nonenal (4-HNE). We previously reported the arrhythmic potential of 4-HNE by suppression of cardiac human Ether-a-go-go Related Gene (hERG) K(+) channels with prolonged action potential duration (A...

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Detalles Bibliográficos
Autores principales: Choi, Seong-Woo, Yin, Ming-Zhe, Park, Na-Kyeong, Woo, Joo-Han, Kim, Sung-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301175/
https://www.ncbi.nlm.nih.gov/pubmed/34356372
http://dx.doi.org/10.3390/antiox10071139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301175/
https://www.ncbi.nlm.nih.gov/pubmed/34356372
http://dx.doi.org/10.3390/antiox10071139

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