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Estimated Phytate Intake Is Associated with Improved Cognitive Function in the Elderly, NHANES 2013–2014

Phytate, an antioxidant, may improve cognition by inhibiting iron catalyzed hydroxyl radical formation. Particularly in the elderly, this provides a potential dietary approach for mitigating age-related brain neuronal dysfunction and loss. In this study, we investigated the relationship between phyt...

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Autores principales: Larvie, Doreen Y, Armah, Seth M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301199/
https://www.ncbi.nlm.nih.gov/pubmed/34356337
http://dx.doi.org/10.3390/antiox10071104
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author Larvie, Doreen Y
Armah, Seth M
author_facet Larvie, Doreen Y
Armah, Seth M
author_sort Larvie, Doreen Y
collection PubMed
description Phytate, an antioxidant, may improve cognition by inhibiting iron catalyzed hydroxyl radical formation. Particularly in the elderly, this provides a potential dietary approach for mitigating age-related brain neuronal dysfunction and loss. In this study, we investigated the relationship between phytate intake and cognitive function in the elderly. We used data from the 2013–2014 National Health and Nutrition Examination Survey (NHANES) and the corresponding Food Patterns Equivalents Database (FPED). Phytate content of food groups from published data were merged with the appropriate FPED data to estimate the total phytate intake for each subject. Principal component analysis was used to develop a composite score from four cognitive function scores in NHANES data, and regression analysis was used to determine the relationship between this score and phytate intake. Median phytate intake was 0.65 (0.61, 0.71) g/day. It was low among females, non-Hispanic blacks, and people with history of at least one chronic disease (p < 0.05). In regression analysis adjusted for confounders, phytate intake was positively associated with cognitive function (β (95% CI) = 1.90 (0.73–3.07); p = 0.015). These results suggest that phytate may be associated with improved cognition, hence the need to consider including phytate-rich foods in the diet among the elderly.
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spelling pubmed-83011992021-07-24 Estimated Phytate Intake Is Associated with Improved Cognitive Function in the Elderly, NHANES 2013–2014 Larvie, Doreen Y Armah, Seth M Antioxidants (Basel) Article Phytate, an antioxidant, may improve cognition by inhibiting iron catalyzed hydroxyl radical formation. Particularly in the elderly, this provides a potential dietary approach for mitigating age-related brain neuronal dysfunction and loss. In this study, we investigated the relationship between phytate intake and cognitive function in the elderly. We used data from the 2013–2014 National Health and Nutrition Examination Survey (NHANES) and the corresponding Food Patterns Equivalents Database (FPED). Phytate content of food groups from published data were merged with the appropriate FPED data to estimate the total phytate intake for each subject. Principal component analysis was used to develop a composite score from four cognitive function scores in NHANES data, and regression analysis was used to determine the relationship between this score and phytate intake. Median phytate intake was 0.65 (0.61, 0.71) g/day. It was low among females, non-Hispanic blacks, and people with history of at least one chronic disease (p < 0.05). In regression analysis adjusted for confounders, phytate intake was positively associated with cognitive function (β (95% CI) = 1.90 (0.73–3.07); p = 0.015). These results suggest that phytate may be associated with improved cognition, hence the need to consider including phytate-rich foods in the diet among the elderly. MDPI 2021-07-10 /pmc/articles/PMC8301199/ /pubmed/34356337 http://dx.doi.org/10.3390/antiox10071104 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Larvie, Doreen Y
Armah, Seth M
Estimated Phytate Intake Is Associated with Improved Cognitive Function in the Elderly, NHANES 2013–2014
title Estimated Phytate Intake Is Associated with Improved Cognitive Function in the Elderly, NHANES 2013–2014
title_full Estimated Phytate Intake Is Associated with Improved Cognitive Function in the Elderly, NHANES 2013–2014
title_fullStr Estimated Phytate Intake Is Associated with Improved Cognitive Function in the Elderly, NHANES 2013–2014
title_full_unstemmed Estimated Phytate Intake Is Associated with Improved Cognitive Function in the Elderly, NHANES 2013–2014
title_short Estimated Phytate Intake Is Associated with Improved Cognitive Function in the Elderly, NHANES 2013–2014
title_sort estimated phytate intake is associated with improved cognitive function in the elderly, nhanes 2013–2014
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301199/
https://www.ncbi.nlm.nih.gov/pubmed/34356337
http://dx.doi.org/10.3390/antiox10071104
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