Cognitive Impact by Blood Circulating Anti-NMDAR1 Autoantibodies

Antibodies persist months and years in blood. Chronic presence of low titers of blood circulating anti-NMDAR1 autoantibodies are sufficient to impair cognitive function in the integrity of the BBB in mice, suggesting potential cognitive damaging effects of low titers of blood circulating anti-NMDAR1...

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Detalles Bibliográficos
Autor principal: Zhou, Xianjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301263/
https://www.ncbi.nlm.nih.gov/pubmed/34307898
http://dx.doi.org/10.20900/jpbs.20210009
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author Zhou, Xianjin
author_facet Zhou, Xianjin
author_sort Zhou, Xianjin
collection PubMed
description Antibodies persist months and years in blood. Chronic presence of low titers of blood circulating anti-NMDAR1 autoantibodies are sufficient to impair cognitive function in the integrity of the BBB in mice, suggesting potential cognitive damaging effects of low titers of blood circulating anti-NMDAR1 autoantibodies in the general human population and psychiatric patients. Investigation of anti-NMDAR1 autoantibodies against individual NMDAR1 antigenic epitopes may potentially provide risk biomarkers and therapeutic targets for development of immunotherapy as a precision medicine for psychiatric patients in the future.
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spelling pubmed-83012632021-07-23 Cognitive Impact by Blood Circulating Anti-NMDAR1 Autoantibodies Zhou, Xianjin J Psychiatr Brain Sci Article Antibodies persist months and years in blood. Chronic presence of low titers of blood circulating anti-NMDAR1 autoantibodies are sufficient to impair cognitive function in the integrity of the BBB in mice, suggesting potential cognitive damaging effects of low titers of blood circulating anti-NMDAR1 autoantibodies in the general human population and psychiatric patients. Investigation of anti-NMDAR1 autoantibodies against individual NMDAR1 antigenic epitopes may potentially provide risk biomarkers and therapeutic targets for development of immunotherapy as a precision medicine for psychiatric patients in the future. 2021-06-28 2021 /pmc/articles/PMC8301263/ /pubmed/34307898 http://dx.doi.org/10.20900/jpbs.20210009 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms and conditions of Creative Commons Attribution 4.0 International License. http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Article
Zhou, Xianjin
Cognitive Impact by Blood Circulating Anti-NMDAR1 Autoantibodies
title Cognitive Impact by Blood Circulating Anti-NMDAR1 Autoantibodies
title_full Cognitive Impact by Blood Circulating Anti-NMDAR1 Autoantibodies
title_fullStr Cognitive Impact by Blood Circulating Anti-NMDAR1 Autoantibodies
title_full_unstemmed Cognitive Impact by Blood Circulating Anti-NMDAR1 Autoantibodies
title_short Cognitive Impact by Blood Circulating Anti-NMDAR1 Autoantibodies
title_sort cognitive impact by blood circulating anti-nmdar1 autoantibodies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301263/
https://www.ncbi.nlm.nih.gov/pubmed/34307898
http://dx.doi.org/10.20900/jpbs.20210009
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