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Medullary Carcinoma of the Colon: A Histopathologic Challenge

Medullary carcinoma (MC) of the colon is a rare and unique histologic subtype of colorectal cancer. It is commonly associated with deficient mismatch repair proteins and has a strong association with Lynch syndrome. Diagnosis is challenging as it does not have the usual immunohistochemical stains on...

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Detalles Bibliográficos
Autores principales: Fatima, Zainab, Sharma, Purva, Youssef, Bahaaeldin, Krishnan, Koyamangalath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301270/
https://www.ncbi.nlm.nih.gov/pubmed/34327072
http://dx.doi.org/10.7759/cureus.15831
Descripción
Sumario:Medullary carcinoma (MC) of the colon is a rare and unique histologic subtype of colorectal cancer. It is commonly associated with deficient mismatch repair proteins and has a strong association with Lynch syndrome. Diagnosis is challenging as it does not have the usual immunohistochemical stains on pathology seen in colorectal adenocarcinoma. Here, we discuss an interesting case of MC of the colon that was metastatic on presentation and constituted a diagnostic challenge.