Medullary Carcinoma of the Colon: A Histopathologic Challenge

Medullary carcinoma (MC) of the colon is a rare and unique histologic subtype of colorectal cancer. It is commonly associated with deficient mismatch repair proteins and has a strong association with Lynch syndrome. Diagnosis is challenging as it does not have the usual immunohistochemical stains on...

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Autores principales: Fatima, Zainab, Sharma, Purva, Youssef, Bahaaeldin, Krishnan, Koyamangalath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301270/
https://www.ncbi.nlm.nih.gov/pubmed/34327072
http://dx.doi.org/10.7759/cureus.15831
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author Fatima, Zainab
Sharma, Purva
Youssef, Bahaaeldin
Krishnan, Koyamangalath
author_facet Fatima, Zainab
Sharma, Purva
Youssef, Bahaaeldin
Krishnan, Koyamangalath
author_sort Fatima, Zainab
collection PubMed
description Medullary carcinoma (MC) of the colon is a rare and unique histologic subtype of colorectal cancer. It is commonly associated with deficient mismatch repair proteins and has a strong association with Lynch syndrome. Diagnosis is challenging as it does not have the usual immunohistochemical stains on pathology seen in colorectal adenocarcinoma. Here, we discuss an interesting case of MC of the colon that was metastatic on presentation and constituted a diagnostic challenge.
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spelling pubmed-83012702021-07-28 Medullary Carcinoma of the Colon: A Histopathologic Challenge Fatima, Zainab Sharma, Purva Youssef, Bahaaeldin Krishnan, Koyamangalath Cureus Internal Medicine Medullary carcinoma (MC) of the colon is a rare and unique histologic subtype of colorectal cancer. It is commonly associated with deficient mismatch repair proteins and has a strong association with Lynch syndrome. Diagnosis is challenging as it does not have the usual immunohistochemical stains on pathology seen in colorectal adenocarcinoma. Here, we discuss an interesting case of MC of the colon that was metastatic on presentation and constituted a diagnostic challenge. Cureus 2021-06-22 /pmc/articles/PMC8301270/ /pubmed/34327072 http://dx.doi.org/10.7759/cureus.15831 Text en Copyright © 2021, Fatima et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Fatima, Zainab
Sharma, Purva
Youssef, Bahaaeldin
Krishnan, Koyamangalath
Medullary Carcinoma of the Colon: A Histopathologic Challenge
title Medullary Carcinoma of the Colon: A Histopathologic Challenge
title_full Medullary Carcinoma of the Colon: A Histopathologic Challenge
title_fullStr Medullary Carcinoma of the Colon: A Histopathologic Challenge
title_full_unstemmed Medullary Carcinoma of the Colon: A Histopathologic Challenge
title_short Medullary Carcinoma of the Colon: A Histopathologic Challenge
title_sort medullary carcinoma of the colon: a histopathologic challenge
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301270/
https://www.ncbi.nlm.nih.gov/pubmed/34327072
http://dx.doi.org/10.7759/cureus.15831
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