Biologic Therapy and Severe Asthma in Children

Severe asthma is a heterogeneous, complex and chronic disease widespread in the pediatric population. According to the recent findings about the different endotypes of asthma in children, each one characterized by specific intracellular molecular pathways, several innovative biologic therapies have...

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Detalles Bibliográficos
Autores principales: Russo, Daniele, Di Filippo, Paola, Attanasi, Marina, Lizzi, Mauro, Di Pillo, Sabrina, Chiarelli, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301339/
https://www.ncbi.nlm.nih.gov/pubmed/34209312
http://dx.doi.org/10.3390/biomedicines9070760
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author Russo, Daniele
Di Filippo, Paola
Attanasi, Marina
Lizzi, Mauro
Di Pillo, Sabrina
Chiarelli, Francesco
author_facet Russo, Daniele
Di Filippo, Paola
Attanasi, Marina
Lizzi, Mauro
Di Pillo, Sabrina
Chiarelli, Francesco
author_sort Russo, Daniele
collection PubMed
description Severe asthma is a heterogeneous, complex and chronic disease widespread in the pediatric population. According to the recent findings about the different endotypes of asthma in children, each one characterized by specific intracellular molecular pathways, several innovative biologic therapies have been developed. Due to their precise ability to target specific inflammatory type 2 mediators, biologics have revolutionized the care of chronic allergic diseases in the pediatric and adult population. In this review, we aim to provide the latest evidence about the use, indications, efficacy and safety of biologic therapies to treat severe asthma in children and adolescents.
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spelling pubmed-83013392021-07-24 Biologic Therapy and Severe Asthma in Children Russo, Daniele Di Filippo, Paola Attanasi, Marina Lizzi, Mauro Di Pillo, Sabrina Chiarelli, Francesco Biomedicines Review Severe asthma is a heterogeneous, complex and chronic disease widespread in the pediatric population. According to the recent findings about the different endotypes of asthma in children, each one characterized by specific intracellular molecular pathways, several innovative biologic therapies have been developed. Due to their precise ability to target specific inflammatory type 2 mediators, biologics have revolutionized the care of chronic allergic diseases in the pediatric and adult population. In this review, we aim to provide the latest evidence about the use, indications, efficacy and safety of biologic therapies to treat severe asthma in children and adolescents. MDPI 2021-06-30 /pmc/articles/PMC8301339/ /pubmed/34209312 http://dx.doi.org/10.3390/biomedicines9070760 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Russo, Daniele
Di Filippo, Paola
Attanasi, Marina
Lizzi, Mauro
Di Pillo, Sabrina
Chiarelli, Francesco
Biologic Therapy and Severe Asthma in Children
title Biologic Therapy and Severe Asthma in Children
title_full Biologic Therapy and Severe Asthma in Children
title_fullStr Biologic Therapy and Severe Asthma in Children
title_full_unstemmed Biologic Therapy and Severe Asthma in Children
title_short Biologic Therapy and Severe Asthma in Children
title_sort biologic therapy and severe asthma in children
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301339/
https://www.ncbi.nlm.nih.gov/pubmed/34209312
http://dx.doi.org/10.3390/biomedicines9070760
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