β-Elemene Suppresses Obesity-Induced Imbalance in the Microbiota-Gut-Brain Axis

As a kind of metabolically triggered inflammation, obesity influences the interplay between the central nervous system and the enteral environment. The present study showed that β-elemene, which is contained in various plant substances, had effects on recovering the changes in metabolites occurring...

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Autores principales: Zhou, Yingyu, Qiu, Wanyi, Wang, Yimei, Wang, Rong, Takano, Tomohiro, Li, Xuyang, Zhu, Zhangliang, Nakajima-Adachi, Haruyo, Tanokura, Masaru, Hachimura, Satoshi, Miyakawa, Takuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301405/
https://www.ncbi.nlm.nih.gov/pubmed/34206511
http://dx.doi.org/10.3390/biomedicines9070704
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author Zhou, Yingyu
Qiu, Wanyi
Wang, Yimei
Wang, Rong
Takano, Tomohiro
Li, Xuyang
Zhu, Zhangliang
Nakajima-Adachi, Haruyo
Tanokura, Masaru
Hachimura, Satoshi
Miyakawa, Takuya
author_facet Zhou, Yingyu
Qiu, Wanyi
Wang, Yimei
Wang, Rong
Takano, Tomohiro
Li, Xuyang
Zhu, Zhangliang
Nakajima-Adachi, Haruyo
Tanokura, Masaru
Hachimura, Satoshi
Miyakawa, Takuya
author_sort Zhou, Yingyu
collection PubMed
description As a kind of metabolically triggered inflammation, obesity influences the interplay between the central nervous system and the enteral environment. The present study showed that β-elemene, which is contained in various plant substances, had effects on recovering the changes in metabolites occurring in high-fat diet (HFD)-induced obese C57BL/6 male mice brains, especially in the prefrontal cortex (PFC) and hippocampus (HIP). β-elemene also partially reversed HFD-induced changes in the composition and contents of mouse gut bacteria. Furthermore, we evaluated the interaction between cerebral metabolites and intestinal microbiota via Pearson correlations. The prediction results suggested that Firmicutes were possibly controlled by neuron integrity, cerebral inflammation, and neurotransmitters, and Bacteroidetes in mouse intestines might be related to cerebral aerobic respiration and the glucose cycle. Such results also implied that Actinobacteria probably affected cerebral energy metabolism. These findings suggested that β-elemene has regulatory effects on the imbalanced microbiota-gut-brain axis caused by obesity and, therefore, would contribute to the future study in on the interplay between cerebral metabolites from different brain regions and the intestinal microbiota of mice.
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spelling pubmed-83014052021-07-24 β-Elemene Suppresses Obesity-Induced Imbalance in the Microbiota-Gut-Brain Axis Zhou, Yingyu Qiu, Wanyi Wang, Yimei Wang, Rong Takano, Tomohiro Li, Xuyang Zhu, Zhangliang Nakajima-Adachi, Haruyo Tanokura, Masaru Hachimura, Satoshi Miyakawa, Takuya Biomedicines Article As a kind of metabolically triggered inflammation, obesity influences the interplay between the central nervous system and the enteral environment. The present study showed that β-elemene, which is contained in various plant substances, had effects on recovering the changes in metabolites occurring in high-fat diet (HFD)-induced obese C57BL/6 male mice brains, especially in the prefrontal cortex (PFC) and hippocampus (HIP). β-elemene also partially reversed HFD-induced changes in the composition and contents of mouse gut bacteria. Furthermore, we evaluated the interaction between cerebral metabolites and intestinal microbiota via Pearson correlations. The prediction results suggested that Firmicutes were possibly controlled by neuron integrity, cerebral inflammation, and neurotransmitters, and Bacteroidetes in mouse intestines might be related to cerebral aerobic respiration and the glucose cycle. Such results also implied that Actinobacteria probably affected cerebral energy metabolism. These findings suggested that β-elemene has regulatory effects on the imbalanced microbiota-gut-brain axis caused by obesity and, therefore, would contribute to the future study in on the interplay between cerebral metabolites from different brain regions and the intestinal microbiota of mice. MDPI 2021-06-22 /pmc/articles/PMC8301405/ /pubmed/34206511 http://dx.doi.org/10.3390/biomedicines9070704 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhou, Yingyu
Qiu, Wanyi
Wang, Yimei
Wang, Rong
Takano, Tomohiro
Li, Xuyang
Zhu, Zhangliang
Nakajima-Adachi, Haruyo
Tanokura, Masaru
Hachimura, Satoshi
Miyakawa, Takuya
β-Elemene Suppresses Obesity-Induced Imbalance in the Microbiota-Gut-Brain Axis
title β-Elemene Suppresses Obesity-Induced Imbalance in the Microbiota-Gut-Brain Axis
title_full β-Elemene Suppresses Obesity-Induced Imbalance in the Microbiota-Gut-Brain Axis
title_fullStr β-Elemene Suppresses Obesity-Induced Imbalance in the Microbiota-Gut-Brain Axis
title_full_unstemmed β-Elemene Suppresses Obesity-Induced Imbalance in the Microbiota-Gut-Brain Axis
title_short β-Elemene Suppresses Obesity-Induced Imbalance in the Microbiota-Gut-Brain Axis
title_sort β-elemene suppresses obesity-induced imbalance in the microbiota-gut-brain axis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301405/
https://www.ncbi.nlm.nih.gov/pubmed/34206511
http://dx.doi.org/10.3390/biomedicines9070704
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