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High-Density Lipoprotein Subfractions: Much Ado about Nothing or Clinically Important?
High-density lipoproteins (HDL) are a heterogenous group of plasma molecules with a large variety in composition. There is a wide specter in lipid content and the number of different proteins that has been associated with HDL is approaching 100. Given this heterogeneity and the fact that the total a...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301429/ https://www.ncbi.nlm.nih.gov/pubmed/34356900 http://dx.doi.org/10.3390/biomedicines9070836 |
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author | Lappegård, Knut Tore Kjellmo, Christian Abendstein Hovland, Anders |
author_facet | Lappegård, Knut Tore Kjellmo, Christian Abendstein Hovland, Anders |
author_sort | Lappegård, Knut Tore |
collection | PubMed |
description | High-density lipoproteins (HDL) are a heterogenous group of plasma molecules with a large variety in composition. There is a wide specter in lipid content and the number of different proteins that has been associated with HDL is approaching 100. Given this heterogeneity and the fact that the total amount of HDL is inversely related to the risk of coronary heart disease (CHD), there has been increasing interest in the function of specific HDL subgroups and in what way measuring and quantifying these subgroups could be of clinical importance in determining individual CHD risk. If certain subgroups appear to be more protective than others, it may also in the future be possible to pharmacologically increase beneficial and decrease harmful subgroups in order to reduce CHD risk. In this review we give a short historical perspective, summarize some of the recent clinical findings regarding HDL subclassifications and discuss why such classification may or may not be of clinical relevance. |
format | Online Article Text |
id | pubmed-8301429 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83014292021-07-24 High-Density Lipoprotein Subfractions: Much Ado about Nothing or Clinically Important? Lappegård, Knut Tore Kjellmo, Christian Abendstein Hovland, Anders Biomedicines Review High-density lipoproteins (HDL) are a heterogenous group of plasma molecules with a large variety in composition. There is a wide specter in lipid content and the number of different proteins that has been associated with HDL is approaching 100. Given this heterogeneity and the fact that the total amount of HDL is inversely related to the risk of coronary heart disease (CHD), there has been increasing interest in the function of specific HDL subgroups and in what way measuring and quantifying these subgroups could be of clinical importance in determining individual CHD risk. If certain subgroups appear to be more protective than others, it may also in the future be possible to pharmacologically increase beneficial and decrease harmful subgroups in order to reduce CHD risk. In this review we give a short historical perspective, summarize some of the recent clinical findings regarding HDL subclassifications and discuss why such classification may or may not be of clinical relevance. MDPI 2021-07-18 /pmc/articles/PMC8301429/ /pubmed/34356900 http://dx.doi.org/10.3390/biomedicines9070836 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lappegård, Knut Tore Kjellmo, Christian Abendstein Hovland, Anders High-Density Lipoprotein Subfractions: Much Ado about Nothing or Clinically Important? |
title | High-Density Lipoprotein Subfractions: Much Ado about Nothing or Clinically Important? |
title_full | High-Density Lipoprotein Subfractions: Much Ado about Nothing or Clinically Important? |
title_fullStr | High-Density Lipoprotein Subfractions: Much Ado about Nothing or Clinically Important? |
title_full_unstemmed | High-Density Lipoprotein Subfractions: Much Ado about Nothing or Clinically Important? |
title_short | High-Density Lipoprotein Subfractions: Much Ado about Nothing or Clinically Important? |
title_sort | high-density lipoprotein subfractions: much ado about nothing or clinically important? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301429/ https://www.ncbi.nlm.nih.gov/pubmed/34356900 http://dx.doi.org/10.3390/biomedicines9070836 |
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