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Comparing Patient Characteristics, Clinical Outcomes, and Biomarkers of Severe Asthma Patients in Taiwan

Purpose: To understand the association between biomarkers and exacerbations of severe asthma in adult patients in Taiwan. Materials and Methods: Demographic, clinical characteristics and biomarkers were retrospectively collected from the medical charts of severe asthma patients in six hospitals in T...

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Autores principales: Cheng, Shih-Lung, Chiu, Kuo-Chin, Ko, Hsin-Kuo, Perng, Diahn-Warng, Wang, Hao-Chien, Yu, Chong-Jen, Sheu, Chau-Chyun, Lin, Sheng-Hao, Lin, Ching-Hsiung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301447/
https://www.ncbi.nlm.nih.gov/pubmed/34356828
http://dx.doi.org/10.3390/biomedicines9070764
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author Cheng, Shih-Lung
Chiu, Kuo-Chin
Ko, Hsin-Kuo
Perng, Diahn-Warng
Wang, Hao-Chien
Yu, Chong-Jen
Sheu, Chau-Chyun
Lin, Sheng-Hao
Lin, Ching-Hsiung
author_facet Cheng, Shih-Lung
Chiu, Kuo-Chin
Ko, Hsin-Kuo
Perng, Diahn-Warng
Wang, Hao-Chien
Yu, Chong-Jen
Sheu, Chau-Chyun
Lin, Sheng-Hao
Lin, Ching-Hsiung
author_sort Cheng, Shih-Lung
collection PubMed
description Purpose: To understand the association between biomarkers and exacerbations of severe asthma in adult patients in Taiwan. Materials and Methods: Demographic, clinical characteristics and biomarkers were retrospectively collected from the medical charts of severe asthma patients in six hospitals in Taiwan. Exacerbations were defined as those requiring asthma-specific emergency department visits/hospitalizations, or systemic steroids. Enrolled patients were divided into: (1) those with no exacerbations (non-exacerbators) and (2) those with one or more exacerbations (exacerbators). Receiver operating characteristic curves were used to determine the optimal cut-off value for biomarkers. Generalized linear models evaluated the association between exacerbation and biomarkers. Results: 132 patients were enrolled in the study with 80 non-exacerbators and 52 exacerbators. There was no significant difference in demographic and clinical characteristics between the two groups. Exacerbators had significantly higher eosinophils (EOS) counts (367.8 ± 357.18 vs. 210.05 ± 175.24, p = 0.0043) compared to non-exacerbators. The optimal cut-off values were 292 for EOS counts and 19 for the Fractional exhaled Nitric Oxide (FeNO) measure. Patients with an EOS count ≥ 300 (RR = 1.88; 95% CI, 1.26–2.81; p = 0.002) or FeNO measure ≥ 20 (RR = 2.10; 95% CI, 1.05–4.18; p = 0.0356) had a significantly higher risk of exacerbation. Moreover, patients with both an EOS count ≥ 300 and FeNO measure ≥ 20 had a significantly higher risk of exacerbation than those with lower EOS count or lower FeNO measure (RR = 2.16; 95% CI, 1.47–3.18; p = < 0.0001). Conclusions: Higher EOS counts and FeNO measures were associated with increased risk of exacerbation. These biomarkers may help physicians identify patients at risk of exacerbations and personalize treatment for asthma patients.
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spelling pubmed-83014472021-07-24 Comparing Patient Characteristics, Clinical Outcomes, and Biomarkers of Severe Asthma Patients in Taiwan Cheng, Shih-Lung Chiu, Kuo-Chin Ko, Hsin-Kuo Perng, Diahn-Warng Wang, Hao-Chien Yu, Chong-Jen Sheu, Chau-Chyun Lin, Sheng-Hao Lin, Ching-Hsiung Biomedicines Article Purpose: To understand the association between biomarkers and exacerbations of severe asthma in adult patients in Taiwan. Materials and Methods: Demographic, clinical characteristics and biomarkers were retrospectively collected from the medical charts of severe asthma patients in six hospitals in Taiwan. Exacerbations were defined as those requiring asthma-specific emergency department visits/hospitalizations, or systemic steroids. Enrolled patients were divided into: (1) those with no exacerbations (non-exacerbators) and (2) those with one or more exacerbations (exacerbators). Receiver operating characteristic curves were used to determine the optimal cut-off value for biomarkers. Generalized linear models evaluated the association between exacerbation and biomarkers. Results: 132 patients were enrolled in the study with 80 non-exacerbators and 52 exacerbators. There was no significant difference in demographic and clinical characteristics between the two groups. Exacerbators had significantly higher eosinophils (EOS) counts (367.8 ± 357.18 vs. 210.05 ± 175.24, p = 0.0043) compared to non-exacerbators. The optimal cut-off values were 292 for EOS counts and 19 for the Fractional exhaled Nitric Oxide (FeNO) measure. Patients with an EOS count ≥ 300 (RR = 1.88; 95% CI, 1.26–2.81; p = 0.002) or FeNO measure ≥ 20 (RR = 2.10; 95% CI, 1.05–4.18; p = 0.0356) had a significantly higher risk of exacerbation. Moreover, patients with both an EOS count ≥ 300 and FeNO measure ≥ 20 had a significantly higher risk of exacerbation than those with lower EOS count or lower FeNO measure (RR = 2.16; 95% CI, 1.47–3.18; p = < 0.0001). Conclusions: Higher EOS counts and FeNO measures were associated with increased risk of exacerbation. These biomarkers may help physicians identify patients at risk of exacerbations and personalize treatment for asthma patients. MDPI 2021-07-01 /pmc/articles/PMC8301447/ /pubmed/34356828 http://dx.doi.org/10.3390/biomedicines9070764 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cheng, Shih-Lung
Chiu, Kuo-Chin
Ko, Hsin-Kuo
Perng, Diahn-Warng
Wang, Hao-Chien
Yu, Chong-Jen
Sheu, Chau-Chyun
Lin, Sheng-Hao
Lin, Ching-Hsiung
Comparing Patient Characteristics, Clinical Outcomes, and Biomarkers of Severe Asthma Patients in Taiwan
title Comparing Patient Characteristics, Clinical Outcomes, and Biomarkers of Severe Asthma Patients in Taiwan
title_full Comparing Patient Characteristics, Clinical Outcomes, and Biomarkers of Severe Asthma Patients in Taiwan
title_fullStr Comparing Patient Characteristics, Clinical Outcomes, and Biomarkers of Severe Asthma Patients in Taiwan
title_full_unstemmed Comparing Patient Characteristics, Clinical Outcomes, and Biomarkers of Severe Asthma Patients in Taiwan
title_short Comparing Patient Characteristics, Clinical Outcomes, and Biomarkers of Severe Asthma Patients in Taiwan
title_sort comparing patient characteristics, clinical outcomes, and biomarkers of severe asthma patients in taiwan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301447/
https://www.ncbi.nlm.nih.gov/pubmed/34356828
http://dx.doi.org/10.3390/biomedicines9070764
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