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The Oscillatory Profile Induced by the Anxiogenic Drug FG-7142 in the Amygdala–Hippocampal Network Is Reversed by Infralimbic Deep Brain Stimulation: Relevance for Mood Disorders

Anxiety and depression exhibit high comorbidity and share the alteration of the amygdala–hippocampal–prefrontal network, playing different roles in the ventral and dorsal hippocampi. Deep brain stimulation of the infralimbic cortex in rodents or the human equivalent—the subgenual cingulate cortex—co...

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Autores principales: Vila-Merkle, Hanna, González-Martínez, Alicia, Campos-Jiménez, Rut, Martínez-Ricós, Joana, Teruel-Martí, Vicent, Blasco-Serra, Arantxa, Lloret, Ana, Celada, Pau, Cervera-Ferri, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301458/
https://www.ncbi.nlm.nih.gov/pubmed/34356846
http://dx.doi.org/10.3390/biomedicines9070783
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author Vila-Merkle, Hanna
González-Martínez, Alicia
Campos-Jiménez, Rut
Martínez-Ricós, Joana
Teruel-Martí, Vicent
Blasco-Serra, Arantxa
Lloret, Ana
Celada, Pau
Cervera-Ferri, Ana
author_facet Vila-Merkle, Hanna
González-Martínez, Alicia
Campos-Jiménez, Rut
Martínez-Ricós, Joana
Teruel-Martí, Vicent
Blasco-Serra, Arantxa
Lloret, Ana
Celada, Pau
Cervera-Ferri, Ana
author_sort Vila-Merkle, Hanna
collection PubMed
description Anxiety and depression exhibit high comorbidity and share the alteration of the amygdala–hippocampal–prefrontal network, playing different roles in the ventral and dorsal hippocampi. Deep brain stimulation of the infralimbic cortex in rodents or the human equivalent—the subgenual cingulate cortex—constitutes a fast antidepressant treatment. The aim of this work was: (1) to describe the oscillatory profile in a rodent model of anxiety, and (2) to deepen the therapeutic basis of infralimbic deep brain stimulation in mood disorders. First, the anxiogenic drug FG-7142 was administered to anaesthetized rats to characterize neural oscillations within the amygdala and the dorsoventral axis of the hippocampus. Next, deep brain stimulation was applied. FG-7142 administration drastically reduced the slow waves, increasing delta, low theta, and beta oscillations in the network. Moreover, FG-7142 altered communication in these bands in selective subnetworks. Deep brain stimulation of the infralimbic cortex reversed most of these FG-7142 effects. Cross-frequency coupling was also inversely modified by FG-7142 and by deep brain stimulation. Our study demonstrates that the hyperactivated amygdala–hippocampal network associated with the anxiogenic drug exhibits an oscillatory fingerprint. The study contributes to comprehending the neurobiological basis of anxiety and the effects of infralimbic deep brain stimulation.
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spelling pubmed-83014582021-07-24 The Oscillatory Profile Induced by the Anxiogenic Drug FG-7142 in the Amygdala–Hippocampal Network Is Reversed by Infralimbic Deep Brain Stimulation: Relevance for Mood Disorders Vila-Merkle, Hanna González-Martínez, Alicia Campos-Jiménez, Rut Martínez-Ricós, Joana Teruel-Martí, Vicent Blasco-Serra, Arantxa Lloret, Ana Celada, Pau Cervera-Ferri, Ana Biomedicines Article Anxiety and depression exhibit high comorbidity and share the alteration of the amygdala–hippocampal–prefrontal network, playing different roles in the ventral and dorsal hippocampi. Deep brain stimulation of the infralimbic cortex in rodents or the human equivalent—the subgenual cingulate cortex—constitutes a fast antidepressant treatment. The aim of this work was: (1) to describe the oscillatory profile in a rodent model of anxiety, and (2) to deepen the therapeutic basis of infralimbic deep brain stimulation in mood disorders. First, the anxiogenic drug FG-7142 was administered to anaesthetized rats to characterize neural oscillations within the amygdala and the dorsoventral axis of the hippocampus. Next, deep brain stimulation was applied. FG-7142 administration drastically reduced the slow waves, increasing delta, low theta, and beta oscillations in the network. Moreover, FG-7142 altered communication in these bands in selective subnetworks. Deep brain stimulation of the infralimbic cortex reversed most of these FG-7142 effects. Cross-frequency coupling was also inversely modified by FG-7142 and by deep brain stimulation. Our study demonstrates that the hyperactivated amygdala–hippocampal network associated with the anxiogenic drug exhibits an oscillatory fingerprint. The study contributes to comprehending the neurobiological basis of anxiety and the effects of infralimbic deep brain stimulation. MDPI 2021-07-06 /pmc/articles/PMC8301458/ /pubmed/34356846 http://dx.doi.org/10.3390/biomedicines9070783 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vila-Merkle, Hanna
González-Martínez, Alicia
Campos-Jiménez, Rut
Martínez-Ricós, Joana
Teruel-Martí, Vicent
Blasco-Serra, Arantxa
Lloret, Ana
Celada, Pau
Cervera-Ferri, Ana
The Oscillatory Profile Induced by the Anxiogenic Drug FG-7142 in the Amygdala–Hippocampal Network Is Reversed by Infralimbic Deep Brain Stimulation: Relevance for Mood Disorders
title The Oscillatory Profile Induced by the Anxiogenic Drug FG-7142 in the Amygdala–Hippocampal Network Is Reversed by Infralimbic Deep Brain Stimulation: Relevance for Mood Disorders
title_full The Oscillatory Profile Induced by the Anxiogenic Drug FG-7142 in the Amygdala–Hippocampal Network Is Reversed by Infralimbic Deep Brain Stimulation: Relevance for Mood Disorders
title_fullStr The Oscillatory Profile Induced by the Anxiogenic Drug FG-7142 in the Amygdala–Hippocampal Network Is Reversed by Infralimbic Deep Brain Stimulation: Relevance for Mood Disorders
title_full_unstemmed The Oscillatory Profile Induced by the Anxiogenic Drug FG-7142 in the Amygdala–Hippocampal Network Is Reversed by Infralimbic Deep Brain Stimulation: Relevance for Mood Disorders
title_short The Oscillatory Profile Induced by the Anxiogenic Drug FG-7142 in the Amygdala–Hippocampal Network Is Reversed by Infralimbic Deep Brain Stimulation: Relevance for Mood Disorders
title_sort oscillatory profile induced by the anxiogenic drug fg-7142 in the amygdala–hippocampal network is reversed by infralimbic deep brain stimulation: relevance for mood disorders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301458/
https://www.ncbi.nlm.nih.gov/pubmed/34356846
http://dx.doi.org/10.3390/biomedicines9070783
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