Cargando…

Neuroinflammation in Ischemic Stroke: Inhibition of cAMP-Specific Phosphodiesterases (PDEs) to the Rescue

Ischemic stroke is caused by a thromboembolic occlusion of a major cerebral artery, with the impaired blood flow triggering neuroinflammation and subsequent neuronal damage. Both the innate immune system (e.g., neutrophils, monocytes/macrophages) in the acute ischemic stroke phase and the adaptive i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ponsaerts, Laura, Alders, Lotte, Schepers, Melissa, de Oliveira, Rúbia Maria Weffort, Prickaerts, Jos, Vanmierlo, Tim, Bronckaers, Annelies
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301462/ https://www.ncbi.nlm.nih.gov/pubmed/34206420 http://dx.doi.org/10.3390/biomedicines9070703

Ejemplares similares

Editorial: Cyclic Nucleotide Phosphodiesterases (PDEs) in Immune Regulation and Inflammation
por: Brocke, Stefan, et al.
Publicado: (2022)

Metabolic benefits of inhibiting cAMP-PDEs with resveratrol
por: Chung, Jay H.
Publicado: (2012)

Novel insights in phosphodiesterase 4 subtype inhibition to target neuroinflammation and stimulate remyelination
por: Schepers, Melissa, et al.
Publicado: (2023)

Unleashing Spinal Cord Repair: The Role of cAMP-Specific PDE Inhibition in Attenuating Neuroinflammation and Boosting Regeneration after Traumatic Spinal Cord Injury
por: Mussen, Femke, et al.
Publicado: (2023)

Phosphodiesterases and cAMP Pathway in Pituitary Diseases
por: Bizzi, Mariana Ferreira, et al.
Publicado: (2019)

Targeting Phosphodiesterases—Towards a Tailor-Made Approach in Multiple Sclerosis Treatment
por: Schepers, Melissa, et al.
Publicado: (2019)

Expression and function of phosphodiesterases (PDEs) in the rat urinary bladder
por: Zhu, Xiaofei, et al.
Publicado: (2017)

Erratum to: Expression and function of phosphodiesterases (PDEs) in the rat urinary bladder
por: Zhu, Xiaofei, et al.
Publicado: (2017)

An evolutionary analysis of cAMP-specific Phosphodiesterase 4 alternative splicing
por: Johnson, Keven R, et al.
Publicado: (2010)

Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases
por: Park, Sung-Jun, et al.
Publicado: (2012)

Phosphodiesterase-induced cAMP degradation restricts hepatitis B virus infection
por: Evripioti, Antonia Alexandra, et al.
Publicado: (2019)

A cAMP phosphodiesterase is essential for sclerotia formation and virulence in Sclerotinia sclerotiorum
por: Xu, Yan, et al.
Publicado: (2023)

Impaired cAMP processivity by phosphodiesterase-protein kinase A complexes in acrodysostosis
por: Venkatakrishnan, Varun, et al.
Publicado: (2023)

Evolution of multiple phosphodiesterase isoforms in stickleback involved in cAMP signal transduction pathway
por: Sato, Yukuto, et al.
Publicado: (2009)

Overexpression of the Rv0805 phosphodiesterase elicits a cAMP-independent transcriptional response()
por: Matange, Nishad, et al.
Publicado: (2013)

Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4
por: Perera, Ruwan K., et al.
Publicado: (2017)

Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion
por: Flueck, Christian, et al.
Publicado: (2019)

Plasticity and therapeutic potential of cAMP and cGMP-specific phosphodiesterases in Toxoplasma gondii
por: Vo, Kim Chi, et al.
Publicado: (2022)

Inhibition of PDE10A-Rescued TBI-Induced Neuroinflammation and Apoptosis through the cAMP/PKA/NLRP3 Pathway
por: Huang, Jin, et al.
Publicado: (2022)

The Role of Type 4 Phosphodiesterases in Generating Microdomains of cAMP: Large Scale Stochastic Simulations
por: Oliveira, Rodrigo F., et al.
Publicado: (2010)

Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins
por: Tibbo, Amy J., et al.
Publicado: (2022)

Functional Analysis of Two Affinity cAMP Phosphodiesterases in the Nematode-Trapping Fungus Arthrobotrys oligospora
por: Ma, Ni, et al.
Publicado: (2022)

Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis
por: Zhou, Qian, et al.
Publicado: (2023)

Inhibition of cAMP phosphodiesterase by milrinone improves cardiac recovery after deep hypothermic circulatory arrest
por: Troitzsch, D, et al.
Publicado: (2001)

Rolipram, a Phosphodiesterase 4 Inhibitor, Stimulates Inducible cAMP Early Repressor Expression in Osteoblasts
por: Cho, Eun Sook, et al.
Publicado: (2005)

Concerted Regulation of cGMP and cAMP Phosphodiesterases in Early Cardiac Hypertrophy Induced by Angiotensin II
por: Mokni, Walid, et al.
Publicado: (2010)

The cAMP phosphodiesterase Prune localizes to the mitochondrial matrix and promotes mtDNA replication by stabilizing TFAM
por: Zhang, Fan, et al.
Publicado: (2015)

Nucleotide signaling pathway convergence in a cAMP‐sensing bacterial c‐di‐GMP phosphodiesterase
por: Cadby, Ian T, et al.
Publicado: (2019)

Mitochondrial sub-cellular localization of cAMP-specific phosphodiesterase 8A in ovarian follicular cells
por: Lounas, Amel, et al.
Publicado: (2019)

Phosphodiesterases and Compartmentation of cAMP and cGMP Signaling in Regulation of Cardiac Contractility in Normal and Failing Hearts
por: Calamera, Gaia, et al.
Publicado: (2022)

Distribution of adenylyl cyclase/cAMP phosphodiesterase gene, CAPE, in streptophytes reproducing via motile sperm
por: Yamamoto, Chiaki, et al.
Publicado: (2021)

Resveratrol modulates cocaine-induced inhibitory synaptic plasticity in VTA dopamine neurons by inhibiting phosphodiesterases (PDEs)
por: Li, Yan, et al.
Publicado: (2017)

Phosphodiesterase 4 inhibitors and db-cAMP inhibit TNF-α release from human mononuclear cells. Effects of cAMP and cGMP-dependent protein kinase inhibitors
por: Hichami, A., et al.
Publicado: (1996)

EHMTI-0033. The phosphodiesterase 3 inhibitor cilostazol induces migraine-like attacks via cAMP increase
por: Song, G, et al.
Publicado: (2014)

Pharmacophore Modeling and Virtual Screening for the Discovery of New type 4 cAMP Phosphodiesterase (PDE4) Inhibitors
por: Niu, Miaomiao, et al.
Publicado: (2013)

Dominant-Negative Attenuation of cAMP-Selective Phosphodiesterase PDE4D Action Affects Learning and Behavior
por: Bolger, Graeme B., et al.
Publicado: (2020)

Upregulation of Phosphodiesterase 2A Augments T Cell Activation by Changing cGMP/cAMP Cross-Talk
por: Kurelic, Roberta, et al.
Publicado: (2021)

The Complexity and Multiplicity of the Specific cAMP Phosphodiesterase Family: PDE4, Open New Adapted Therapeutic Approaches
por: Lugnier, Claire
Publicado: (2022)

From OPC to Oligodendrocyte: An Epigenetic Journey
por: Tiane, Assia, et al.
Publicado: (2019)

N-Docosahexaenoylethanolamine ameliorates LPS-induced neuroinflammation via cAMP/PKA-dependent signaling
por: Park, Taeyeop, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_j712rk0alc37pr9vnicovmov9e