Cargando…

Lipid droplet screen in human hepatocytes identifies TRRAP as a regulator of cellular triglyceride metabolism

Hepatocytes store triglycerides (TGs) in the form of lipid droplets (LDs), which are increased in hepatosteatosis. The regulation of hepatic LDs is poorly understood and new therapies to reduce hepatosteatosis are needed. We performed a siRNA kinase and phosphatase screen in HuH‐7 cells using high‐c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abbey, Deepti, Conlon, Donna, Rainville, Christopher, Elwyn, Susannah, Quiroz‐Figueroa, Katherine, Billheimer, Jeffrey, Schultz, David C., Hand, Nicholas J., Cherry, Sara, Rader, Daniel J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301584/ https://www.ncbi.nlm.nih.gov/pubmed/34156146 http://dx.doi.org/10.1111/cts.12988

Ejemplares similares

Self‐Organizing Human Induced Pluripotent Stem Cell Hepatocyte 3D Organoids Inform the Biology of the Pleiotropic TRIB1 Gene
por: Abbey, Deepti, et al.
Publicado: (2020)

Involvement of the zebrafish trrap gene in craniofacial development
por: Suzuki, Taichi, et al.
Publicado: (2021)

Sortilin restricts secretion of apolipoprotein B-100 by hepatocytes under stressed but not basal conditions
por: Conlon, Donna M., et al.
Publicado: (2022)

Triglyceride Mobilization from Lipid Droplets Sustains the Anti-Steatotic Action of Iodothyronines in Cultured Rat Hepatocytes
por: Grasselli, Elena, et al.
Publicado: (2016)

Luminescence complementation technology for the identification of MYC:TRRAP inhibitors
por: Feris, Edmond J., et al.
Publicado: (2021)

LSDP5 Enhances Triglyceride Storage in Hepatocytes by Influencing Lipolysis and Fatty Acid β-Oxidation of Lipid Droplets
por: Li, Hang, et al.
Publicado: (2012)

TRRAP is a central regulator of human multiciliated cell formation
por: Wang, Zhao, et al.
Publicado: (2018)

TRRAP stimulates the tumorigenic potential of ovarian cancer stem cells
por: Kang, Kyung Taek, et al.
Publicado: (2018)

TRRAP-mediated acetylation on Sp1 regulates adult neurogenesis
por: Yin, Bo-Kun, et al.
Publicado: (2022)

Beyond HAT Adaptor: TRRAP Liaisons with Sp1-Mediated Transcription
por: Yin, Bo-Kun, et al.
Publicado: (2021)

Analysis of TRRAP as a Potential Molecular Marker and Therapeutic Target for Breast Cancer
por: Wang, Ji, et al.
Publicado: (2016)

Formation of a structurally-stable conformation by the intrinsically disordered MYC:TRRAP complex
por: Feris, Edmond J., et al.
Publicado: (2019)

The Diarylheptanoid Curcumin Induces MYC Inhibition and Cross-Links This Oncoprotein to the Coactivator TRRAP
por: Mödlhammer, Alexander, et al.
Publicado: (2021)

The TRRAP transcription cofactor represses interferon-stimulated genes in colorectal cancer cells
por: Detilleux, Dylane, et al.
Publicado: (2022)

Lipid Droplet-Associated Hydrolase Promotes Lipid Droplet Fusion and Enhances ATGL Degradation and Triglyceride Accumulation
por: Goo, Young-Hwa, et al.
Publicado: (2017)

ARFGAP1 Is Dynamically Associated with Lipid Droplets in Hepatocytes
por: Gannon, Joan, et al.
Publicado: (2014)

Direct lysosome-based autophagy of lipid droplets in hepatocytes
por: Schulze, Ryan J., et al.
Publicado: (2020)

Microsomal triglyceride transfer protein contributes to lipid droplet maturation in adipocytes
por: Swift, Larry L., et al.
Publicado: (2017)

Triglyceride breakdown from lipid droplets regulates the inflammatory response in macrophages
por: van Dierendonck, Xanthe A. M. H., et al.
Publicado: (2022)

HAT cofactor TRRAP modulates microtubule dynamics via SP1 signaling to prevent neurodegeneration
por: Tapias, Alicia, et al.
Publicado: (2021)

Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes
por: Schott, Micah B., et al.
Publicado: (2019)

Lipid droplets are intracellular mechanical stressors that impair hepatocyte function
por: Loneker, Abigail E., et al.
Publicado: (2023)

Endothelial lipase mediates efficient lipolysis of triglyceride-rich lipoproteins
por: Khetarpal, Sumeet A., et al.
Publicado: (2021)

FSP27 Promotes Lipid Droplet Clustering and Then Fusion to Regulate Triglyceride Accumulation
por: Jambunathan, Srikarthika, et al.
Publicado: (2011)

Identification of Diverse Lipid Droplet Targeting Motifs in the PNPLA Family of Triglyceride Lipases
por: Murugesan, Sricharan, et al.
Publicado: (2013)

Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase
por: Padmanabha Das, Krishna M., et al.
Publicado: (2018)

Insulin activates intracellular transport of lipid droplets to release triglycerides from the liver
por: Kumar, Mukesh, et al.
Publicado: (2019)

Making Droplet-Embedded Vesicles to Model Cellular Lipid Droplets
por: Chorlay, Aymeric, et al.
Publicado: (2020)

TRRAP Enhances Cancer Stem Cell Characteristics by Regulating NANOG Protein Stability in Colon Cancer Cells
por: Kang, Kyung-Taek, et al.
Publicado: (2023)

Altered Lipid Droplet Dynamics in Hepatocytes Lacking Triacylglycerol Hydrolase Expression
por: Wang, Huajin, et al.
Publicado: (2010)

Lipid Droplets and the Management of Cellular Stress
por: Jarc, Eva, et al.
Publicado: (2019)

ELMOD2 is anchored to lipid droplets by palmitoylation and regulates adipocyte triglyceride lipase recruitment
por: Suzuki, Michitaka, et al.
Publicado: (2015)

Pre-existing bilayer stresses modulate triglyceride accumulation in the ER versus lipid droplets
por: Zoni, Valeria, et al.
Publicado: (2021)

Triglyceride lipolysis triggers liquid crystalline phases in lipid droplets and alters the LD proteome
por: Rogers, Sean, et al.
Publicado: (2022)

Mutational analysis of the GNA11, MMP27, FGD1, TRRAP and GRM3 genes in thyroid cancer
por: MURUGAN, AVANIYAPURAM KANNAN, et al.
Publicado: (2013)

HSF1 phosphorylation establishes an active chromatin state via the TRRAP–TIP60 complex and promotes tumorigenesis
por: Fujimoto, Mitsuaki, et al.
Publicado: (2022)

Perspectives on Mitochondria–ER and Mitochondria–Lipid Droplet Contact in Hepatocytes and Hepatic Lipid Metabolism
por: Ma, Xiaowen, et al.
Publicado: (2021)

Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis
por: Schlager, Stefanie, et al.
Publicado: (2015)

Triglyceride Blisters in Lipid Bilayers: Implications for Lipid Droplet Biogenesis and the Mobile Lipid Signal in Cancer Cell Membranes
por: Khandelia, Himanshu, et al.
Publicado: (2010)

Lipid droplet breakdown requires Dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes
por: Schulze, Ryan J., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_fp5fhe9nq5ks0fd4kvvaiutaqk