Cargando…

Relationship between Circulating PCSK9 and Markers of Subclinical Atherosclerosis—The IMPROVE Study

(1) Background and purpose: circulating proprotein convertase subtilisin/kexin type 9 (PCSK9) is one of the key regulators of cholesterol metabolism. Despite this, its role as a player in atherosclerosis development is still matter of debate. Here, we investigated the relationships between this prot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Coggi, Daniela, Frigerio, Beatrice, Bonomi, Alice, Ruscica, Massimiliano, Ferri, Nicola, Sansaro, Daniela, Ravani, Alessio, Ferrante, Palma, Damigella, Manuela, Veglia, Fabrizio, Capra, Nicolò, Lupo, Maria Giovanna, Macchi, Chiara, Savonen, Kai, Silveira, Angela, Kurl, Sudhir, Giral, Philippe, Pirro, Matteo, Strawbridge, Rona Juliette, Gigante, Bruna, Smit, Andries Jan, Tremoli, Elena, Amato, Mauro, Baldassarre, Damiano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301759/ https://www.ncbi.nlm.nih.gov/pubmed/34356905 http://dx.doi.org/10.3390/biomedicines9070841

Ejemplares similares

The Association between HDL-C and Subclinical Atherosclerosis Depends on CETP Plasma Concentration: Insights from the IMPROVE Study
por: Colombo, Gualtiero I., et al.
Publicado: (2021)

Relationship between Influenza Vaccination Coverage Rate and COVID-19 Outbreak: An Italian Ecological Study
por: Amato, Mauro, et al.
Publicado: (2020)

Neutrophil to lymphocyte ratio is not related to carotid atherosclerosis progression and cardiovascular events in the primary prevention of cardiovascular disease: Results from the IMPROVE study
por: Mannarino, Massimo R., et al.
Publicado: (2021)

Association Between Uric Acid, Carotid Intima‐Media Thickness, and Cardiovascular Events: Prospective Results From the IMPROVE Study
por: Mannarino, Massimo R., et al.
Publicado: (2021)

A priori-defined Mediterranean-like dietary pattern predicts cardiovascular events better in north Europe than in Mediterranean countries()
por: Veglia, Fabrizio, et al.
Publicado: (2019)

Data on the association between a simplified Mediterranean diet score and the incidence of combined, cardio and cerebro vascular events
por: Veglia, Fabrizio, et al.
Publicado: (2019)

Cross-Sectional Gene-Smoking Interaction Analysis in Relation to Subclinical Atherosclerosis-Results From the IMPROVE Study
por: Maitusong, Buamina, et al.
Publicado: (2023)

Carotid plaque-thickness and common carotid IMT show additive value in cardiovascular risk prediction and reclassification
por: Amato, Mauro, et al.
Publicado: (2017)

Assessment of New Coronary Features on Quantitative Coronary Angiographic Images With Innovative Unsupervised Artificial Adaptive Systems: A Proof-of-Concept Study
por: Amato, Mauro, et al.
Publicado: (2021)

Assessment and Relevance of Carotid Intima-Media Thickness (C-IMT) in Primary and Secondary Cardiovascular Prevention
por: Ravani, Alessio, et al.
Publicado: (2015)

Intake of food rich in saturated fat in relation to subclinical atherosclerosis and potential modulating effects from single genetic variants
por: Laguzzi, Federica, et al.
Publicado: (2021)

Analysis of the genetic variants associated with circulating levels of sgp130. Results from the IMPROVE study
por: Bonomi, Alice, et al.
Publicado: (2020)

Genetic Variants Associated with Non-Alcoholic Fatty Liver Disease Do Not Associate with Measures of Sub-Clinical Atherosclerosis: Results from the IMPROVE Study
por: Castaldo, Luigi, et al.
Publicado: (2020)

The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals
por: Strawbridge, Rona J., et al.
Publicado: (2021)

Alcohol consumption in relation to carotid subclinical atherosclerosis and its progression: results from a European longitudinal multicentre study
por: Laguzzi, Federica, et al.
Publicado: (2020)

Naturally Occurring PCSK9 Inhibitors
por: Adorni, Maria Pia, et al.
Publicado: (2020)

Proteomics and Lipidomics to unveil the contribution of PCSK9 beyond cholesterol lowering: a narrative review
por: Gianazza, Erica, et al.
Publicado: (2023)

Plasma IL-5 concentration and subclinical carotid atherosclerosis
por: Silveira, Angela, et al.
Publicado: (2015)

PCSK9 induces a pro-inflammatory response in macrophages
por: Ricci, Chiara, et al.
Publicado: (2018)

Analysis of the Role of Interleukin 6 Receptor Haplotypes in the Regulation of Circulating Levels of Inflammatory Biomarkers and Risk of Coronary Heart Disease
por: Gigante, Bruna, et al.
Publicado: (2015)

Genetic variation in CADM2 as a link between psychological traits and obesity
por: Morris, Julia, et al.
Publicado: (2019)

PCSK9 Expression in Epicardial Adipose Tissue: Molecular Association with Local Tissue Inflammation
por: Dozio, Elena, et al.
Publicado: (2020)

PCSK9 Levels Are Raised in Chronic HCV Patients with Hepatocellular Carcinoma
por: Fasolato, Silvano, et al.
Publicado: (2020)

PCSK9 Induces Rat Smooth Muscle Cell Proliferation and Counteracts the Pleiotropic Effects of Simvastatin
por: Lupo, Maria Giovanna, et al.
Publicado: (2021)

Impact of Soy β-Conglycinin Peptides on PCSK9 Protein Expression in HepG2 Cells
por: Macchi, Chiara, et al.
Publicado: (2021)

Lipoprotein(a) and PCSK9 inhibition: clinical evidence
por: Ruscica, Massimiliano, et al.
Publicado: (2020)

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease
por: Folkersen, Lasse, et al.
Publicado: (2017)

Subclinical atherosclerosis and its progression are modulated by PLIN2 through a feed‐forward loop between LXR and autophagy
por: Saliba‐Gustafsson, P., et al.
Publicado: (2019)

PCSK9 Inhibition and Risk of Diabetes: Should We Worry?
por: Carugo, Stefano, et al.
Publicado: (2022)

Genetic analysis of the PCSK9 locus in psychological, psychiatric, metabolic and cardiovascular traits in UK Biobank
por: Hay, Rachel, et al.
Publicado: (2022)

Investigating the potential impact of PCSK9-inhibitors on mood disorders using eQTL-based Mendelian randomization
por: Aman, Alisha, et al.
Publicado: (2022)

Hypocholesterolaemic treatment in coronary unit: from statins to anti PCSK9 therapies and bempedoic acid
por: Ferri, Nicola, et al.
Publicado: (2023)

Depression and cardiovascular risk—association among Beck Depression Inventory, PCSK9 levels and insulin resistance
por: Macchi, C., et al.
Publicado: (2020)

Associations Among PCSK9 Levels, Atherosclerosis-Derived Extracellular Vesicles, and Their miRNA Content in Adults With Obesity
por: Macchi, Chiara, et al.
Publicado: (2022)

Trials in “True” Dyslipidemic Patients Are Urged to Reconsider Comprehensive Lipid Management as a Means to Reduce Residual Cardiovascular Risk
por: Werba, José P., et al.
Publicado: (2019)

Circulating PCSK9 as a prognostic biomarker of cardiovascular events in individuals with type 2 diabetes: evidence from a 16.8-year follow-up study
por: Ruscica, Massimiliano, et al.
Publicado: (2023)

PCSK9 Confers Inflammatory Properties to Extracellular Vesicles Released by Vascular Smooth Muscle Cells
por: Greco, Maria Francesca, et al.
Publicado: (2022)

Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease
por: Persson, Jonas, et al.
Publicado: (2015)

Aortic Valve Sclerosis Adds to Prediction of Short-Term Mortality in Patients with Documented Coronary Atherosclerosis
por: Poggio, Paolo, et al.
Publicado: (2019)

PCSK9 Affects Astrocyte Cholesterol Metabolism and Reduces Neuron Cholesterol Supplying In Vitro: Potential Implications in Alzheimer’s Disease
por: Papotti, Bianca, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_820s7b0ngmdsin63723jqlbft4