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Eliciting and Recording Event Related Potentials (ERPs) in Behaviourally Unresponsive Populations: A Retrospective Commentary on Critical Factors

A consistent limitation when designing event-related potential paradigms and interpreting results is a lack of consideration of the multivariate factors that affect their elicitation and detection in behaviorally unresponsive individuals. This paper provides a retrospective commentary on three facto...

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Autores principales: Rokos, Alexander, Mah, Richard, Boshra, Rober, Harrison, Amabilis, Choy, Tsee Leng, Blain-Moraes, Stefanie, Connolly, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301772/
https://www.ncbi.nlm.nih.gov/pubmed/34202435
http://dx.doi.org/10.3390/brainsci11070835
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author Rokos, Alexander
Mah, Richard
Boshra, Rober
Harrison, Amabilis
Choy, Tsee Leng
Blain-Moraes, Stefanie
Connolly, John F.
author_facet Rokos, Alexander
Mah, Richard
Boshra, Rober
Harrison, Amabilis
Choy, Tsee Leng
Blain-Moraes, Stefanie
Connolly, John F.
author_sort Rokos, Alexander
collection PubMed
description A consistent limitation when designing event-related potential paradigms and interpreting results is a lack of consideration of the multivariate factors that affect their elicitation and detection in behaviorally unresponsive individuals. This paper provides a retrospective commentary on three factors that influence the presence and morphology of long-latency event-related potentials—the P3b and N400. We analyze event-related potentials derived from electroencephalographic (EEG) data collected from small groups of healthy youth and healthy elderly to illustrate the effect of paradigm strength and subject age; we analyze ERPs collected from an individual with severe traumatic brain injury to illustrate the effect of stimulus presentation speed. Based on these critical factors, we support that: (1) the strongest paradigms should be used to elicit event-related potentials in unresponsive populations; (2) interpretation of event-related potential results should account for participant age; and (3) speed of stimulus presentation should be slower in unresponsive individuals. The application of these practices when eliciting and recording event-related potentials in unresponsive individuals will help to minimize result interpretation ambiguity, increase confidence in conclusions, and advance the understanding of the relationship between long-latency event-related potentials and states of consciousness.
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spelling pubmed-83017722021-07-24 Eliciting and Recording Event Related Potentials (ERPs) in Behaviourally Unresponsive Populations: A Retrospective Commentary on Critical Factors Rokos, Alexander Mah, Richard Boshra, Rober Harrison, Amabilis Choy, Tsee Leng Blain-Moraes, Stefanie Connolly, John F. Brain Sci Article A consistent limitation when designing event-related potential paradigms and interpreting results is a lack of consideration of the multivariate factors that affect their elicitation and detection in behaviorally unresponsive individuals. This paper provides a retrospective commentary on three factors that influence the presence and morphology of long-latency event-related potentials—the P3b and N400. We analyze event-related potentials derived from electroencephalographic (EEG) data collected from small groups of healthy youth and healthy elderly to illustrate the effect of paradigm strength and subject age; we analyze ERPs collected from an individual with severe traumatic brain injury to illustrate the effect of stimulus presentation speed. Based on these critical factors, we support that: (1) the strongest paradigms should be used to elicit event-related potentials in unresponsive populations; (2) interpretation of event-related potential results should account for participant age; and (3) speed of stimulus presentation should be slower in unresponsive individuals. The application of these practices when eliciting and recording event-related potentials in unresponsive individuals will help to minimize result interpretation ambiguity, increase confidence in conclusions, and advance the understanding of the relationship between long-latency event-related potentials and states of consciousness. MDPI 2021-06-24 /pmc/articles/PMC8301772/ /pubmed/34202435 http://dx.doi.org/10.3390/brainsci11070835 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rokos, Alexander
Mah, Richard
Boshra, Rober
Harrison, Amabilis
Choy, Tsee Leng
Blain-Moraes, Stefanie
Connolly, John F.
Eliciting and Recording Event Related Potentials (ERPs) in Behaviourally Unresponsive Populations: A Retrospective Commentary on Critical Factors
title Eliciting and Recording Event Related Potentials (ERPs) in Behaviourally Unresponsive Populations: A Retrospective Commentary on Critical Factors
title_full Eliciting and Recording Event Related Potentials (ERPs) in Behaviourally Unresponsive Populations: A Retrospective Commentary on Critical Factors
title_fullStr Eliciting and Recording Event Related Potentials (ERPs) in Behaviourally Unresponsive Populations: A Retrospective Commentary on Critical Factors
title_full_unstemmed Eliciting and Recording Event Related Potentials (ERPs) in Behaviourally Unresponsive Populations: A Retrospective Commentary on Critical Factors
title_short Eliciting and Recording Event Related Potentials (ERPs) in Behaviourally Unresponsive Populations: A Retrospective Commentary on Critical Factors
title_sort eliciting and recording event related potentials (erps) in behaviourally unresponsive populations: a retrospective commentary on critical factors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301772/
https://www.ncbi.nlm.nih.gov/pubmed/34202435
http://dx.doi.org/10.3390/brainsci11070835
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