Cargando…
Discriminant Validity of the WAIS-R Digit Symbol Substitution Test in Subjective Cognitive Decline, Mild Cognitive Impairment (Amnestic Subtype) and Alzheimer’s Disease Dementia (ADD) in Greece
Objective: The aim of the current study was to estimate the discriminant potential and validity of the Digit Symbol Substitution Test (DSST) of the WAIS-R in the Greek elderly population meeting criteria for subjective cognitive decline (SCD), mild cognitive impairment (aMCI; amnestic subtype), or A...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301784/ https://www.ncbi.nlm.nih.gov/pubmed/34209189 http://dx.doi.org/10.3390/brainsci11070881 |
_version_ | 1783726750693326848 |
---|---|
author | Tsatali, Marianna Poptsi, Eleni Moraitou, Despina Agogiatou, Christina Bakoglidou, Evaggelia Gialaouzidis, Moses Papasozomenou, Chrysa Soumpourou, Aikaterini Tsolaki, Magdalini |
author_facet | Tsatali, Marianna Poptsi, Eleni Moraitou, Despina Agogiatou, Christina Bakoglidou, Evaggelia Gialaouzidis, Moses Papasozomenou, Chrysa Soumpourou, Aikaterini Tsolaki, Magdalini |
author_sort | Tsatali, Marianna |
collection | PubMed |
description | Objective: The aim of the current study was to estimate the discriminant potential and validity of the Digit Symbol Substitution Test (DSST) of the WAIS-R in the Greek elderly population meeting criteria for subjective cognitive decline (SCD), mild cognitive impairment (aMCI; amnestic subtype), or Alzheimer’s disease dementia (ADD). Method: Four hundred eighty-eight community-dwelling older adults, visitors of the Day Center of Alzheimer Hellas, participated in the study. Two hundred forty-three of them met the criteria for ADD, one hundred eighty-two for aMCI and sixty-three for SCD. Results: Path analysis indicated that the DSST score is affected by age group, educational level, and diagnostic category, but is not affected by gender. The ROC curve analysis showed that the DSST sum score could perfectly differentiate SCD from ADD patients, whereas test’s discriminant potential between aMCI and dementia ADD’s subtype was satisfactory. However, DSST was unable to separate the SCD from the aMCI group. Conclusion: It appears that the DSST is unable to separate the SCD from aMCI population. Therefore, the test in question may be insensitive to incipient cognitive decline. On the contrary, the discriminant potential of the DSST as regards SCD and ADD is excellent, while discrimination between aMCI and ADD is good. |
format | Online Article Text |
id | pubmed-8301784 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83017842021-07-24 Discriminant Validity of the WAIS-R Digit Symbol Substitution Test in Subjective Cognitive Decline, Mild Cognitive Impairment (Amnestic Subtype) and Alzheimer’s Disease Dementia (ADD) in Greece Tsatali, Marianna Poptsi, Eleni Moraitou, Despina Agogiatou, Christina Bakoglidou, Evaggelia Gialaouzidis, Moses Papasozomenou, Chrysa Soumpourou, Aikaterini Tsolaki, Magdalini Brain Sci Article Objective: The aim of the current study was to estimate the discriminant potential and validity of the Digit Symbol Substitution Test (DSST) of the WAIS-R in the Greek elderly population meeting criteria for subjective cognitive decline (SCD), mild cognitive impairment (aMCI; amnestic subtype), or Alzheimer’s disease dementia (ADD). Method: Four hundred eighty-eight community-dwelling older adults, visitors of the Day Center of Alzheimer Hellas, participated in the study. Two hundred forty-three of them met the criteria for ADD, one hundred eighty-two for aMCI and sixty-three for SCD. Results: Path analysis indicated that the DSST score is affected by age group, educational level, and diagnostic category, but is not affected by gender. The ROC curve analysis showed that the DSST sum score could perfectly differentiate SCD from ADD patients, whereas test’s discriminant potential between aMCI and dementia ADD’s subtype was satisfactory. However, DSST was unable to separate the SCD from the aMCI group. Conclusion: It appears that the DSST is unable to separate the SCD from aMCI population. Therefore, the test in question may be insensitive to incipient cognitive decline. On the contrary, the discriminant potential of the DSST as regards SCD and ADD is excellent, while discrimination between aMCI and ADD is good. MDPI 2021-06-30 /pmc/articles/PMC8301784/ /pubmed/34209189 http://dx.doi.org/10.3390/brainsci11070881 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tsatali, Marianna Poptsi, Eleni Moraitou, Despina Agogiatou, Christina Bakoglidou, Evaggelia Gialaouzidis, Moses Papasozomenou, Chrysa Soumpourou, Aikaterini Tsolaki, Magdalini Discriminant Validity of the WAIS-R Digit Symbol Substitution Test in Subjective Cognitive Decline, Mild Cognitive Impairment (Amnestic Subtype) and Alzheimer’s Disease Dementia (ADD) in Greece |
title | Discriminant Validity of the WAIS-R Digit Symbol Substitution Test in Subjective Cognitive Decline, Mild Cognitive Impairment (Amnestic Subtype) and Alzheimer’s Disease Dementia (ADD) in Greece |
title_full | Discriminant Validity of the WAIS-R Digit Symbol Substitution Test in Subjective Cognitive Decline, Mild Cognitive Impairment (Amnestic Subtype) and Alzheimer’s Disease Dementia (ADD) in Greece |
title_fullStr | Discriminant Validity of the WAIS-R Digit Symbol Substitution Test in Subjective Cognitive Decline, Mild Cognitive Impairment (Amnestic Subtype) and Alzheimer’s Disease Dementia (ADD) in Greece |
title_full_unstemmed | Discriminant Validity of the WAIS-R Digit Symbol Substitution Test in Subjective Cognitive Decline, Mild Cognitive Impairment (Amnestic Subtype) and Alzheimer’s Disease Dementia (ADD) in Greece |
title_short | Discriminant Validity of the WAIS-R Digit Symbol Substitution Test in Subjective Cognitive Decline, Mild Cognitive Impairment (Amnestic Subtype) and Alzheimer’s Disease Dementia (ADD) in Greece |
title_sort | discriminant validity of the wais-r digit symbol substitution test in subjective cognitive decline, mild cognitive impairment (amnestic subtype) and alzheimer’s disease dementia (add) in greece |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301784/ https://www.ncbi.nlm.nih.gov/pubmed/34209189 http://dx.doi.org/10.3390/brainsci11070881 |
work_keys_str_mv | AT tsatalimarianna discriminantvalidityofthewaisrdigitsymbolsubstitutiontestinsubjectivecognitivedeclinemildcognitiveimpairmentamnesticsubtypeandalzheimersdiseasedementiaaddingreece AT poptsieleni discriminantvalidityofthewaisrdigitsymbolsubstitutiontestinsubjectivecognitivedeclinemildcognitiveimpairmentamnesticsubtypeandalzheimersdiseasedementiaaddingreece AT moraitoudespina discriminantvalidityofthewaisrdigitsymbolsubstitutiontestinsubjectivecognitivedeclinemildcognitiveimpairmentamnesticsubtypeandalzheimersdiseasedementiaaddingreece AT agogiatouchristina discriminantvalidityofthewaisrdigitsymbolsubstitutiontestinsubjectivecognitivedeclinemildcognitiveimpairmentamnesticsubtypeandalzheimersdiseasedementiaaddingreece AT bakoglidouevaggelia discriminantvalidityofthewaisrdigitsymbolsubstitutiontestinsubjectivecognitivedeclinemildcognitiveimpairmentamnesticsubtypeandalzheimersdiseasedementiaaddingreece AT gialaouzidismoses discriminantvalidityofthewaisrdigitsymbolsubstitutiontestinsubjectivecognitivedeclinemildcognitiveimpairmentamnesticsubtypeandalzheimersdiseasedementiaaddingreece AT papasozomenouchrysa discriminantvalidityofthewaisrdigitsymbolsubstitutiontestinsubjectivecognitivedeclinemildcognitiveimpairmentamnesticsubtypeandalzheimersdiseasedementiaaddingreece AT soumpourouaikaterini discriminantvalidityofthewaisrdigitsymbolsubstitutiontestinsubjectivecognitivedeclinemildcognitiveimpairmentamnesticsubtypeandalzheimersdiseasedementiaaddingreece AT tsolakimagdalini discriminantvalidityofthewaisrdigitsymbolsubstitutiontestinsubjectivecognitivedeclinemildcognitiveimpairmentamnesticsubtypeandalzheimersdiseasedementiaaddingreece |