Ligands of Adrenergic Receptors: A Structural Point of View

Adrenergic receptors are G protein-coupled receptors for epinephrine and norepinephrine. They are targets of many drugs for various conditions, including treatment of hypertension, hypotension, and asthma. Adrenergic receptors are intensively studied in structural biology, displayed for binding pose...

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Detalles Bibliográficos
Autores principales: Wu, Yiran, Zeng, Liting, Zhao, Suwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301793/
https://www.ncbi.nlm.nih.gov/pubmed/34202543
http://dx.doi.org/10.3390/biom11070936
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author Wu, Yiran
Zeng, Liting
Zhao, Suwen
author_facet Wu, Yiran
Zeng, Liting
Zhao, Suwen
author_sort Wu, Yiran
collection PubMed
description Adrenergic receptors are G protein-coupled receptors for epinephrine and norepinephrine. They are targets of many drugs for various conditions, including treatment of hypertension, hypotension, and asthma. Adrenergic receptors are intensively studied in structural biology, displayed for binding poses of different types of ligands. Here, we summarized molecular mechanisms of ligand recognition and receptor activation exhibited by structure. We also reviewed recent advances in structure-based ligand discovery against adrenergic receptors.
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spelling pubmed-83017932021-07-24 Ligands of Adrenergic Receptors: A Structural Point of View Wu, Yiran Zeng, Liting Zhao, Suwen Biomolecules Review Adrenergic receptors are G protein-coupled receptors for epinephrine and norepinephrine. They are targets of many drugs for various conditions, including treatment of hypertension, hypotension, and asthma. Adrenergic receptors are intensively studied in structural biology, displayed for binding poses of different types of ligands. Here, we summarized molecular mechanisms of ligand recognition and receptor activation exhibited by structure. We also reviewed recent advances in structure-based ligand discovery against adrenergic receptors. MDPI 2021-06-24 /pmc/articles/PMC8301793/ /pubmed/34202543 http://dx.doi.org/10.3390/biom11070936 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wu, Yiran
Zeng, Liting
Zhao, Suwen
Ligands of Adrenergic Receptors: A Structural Point of View
title Ligands of Adrenergic Receptors: A Structural Point of View
title_full Ligands of Adrenergic Receptors: A Structural Point of View
title_fullStr Ligands of Adrenergic Receptors: A Structural Point of View
title_full_unstemmed Ligands of Adrenergic Receptors: A Structural Point of View
title_short Ligands of Adrenergic Receptors: A Structural Point of View
title_sort ligands of adrenergic receptors: a structural point of view
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301793/
https://www.ncbi.nlm.nih.gov/pubmed/34202543
http://dx.doi.org/10.3390/biom11070936
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AT zengliting ligandsofadrenergicreceptorsastructuralpointofview
AT zhaosuwen ligandsofadrenergicreceptorsastructuralpointofview

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