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Engineering the Vasculature of Stem-Cell-Derived Liver Organoids
The vasculature of stem-cell-derived liver organoids can be engineered using methods that recapitulate embryonic liver development. Hepatic organoids with a vascular network offer great application prospects for drug screening, disease modeling, and therapeutics. However, the application of stem cel...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301828/ https://www.ncbi.nlm.nih.gov/pubmed/34208902 http://dx.doi.org/10.3390/biom11070966 |
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author | Zhang, Xv Tang, Liling Yi, Qian |
author_facet | Zhang, Xv Tang, Liling Yi, Qian |
author_sort | Zhang, Xv |
collection | PubMed |
description | The vasculature of stem-cell-derived liver organoids can be engineered using methods that recapitulate embryonic liver development. Hepatic organoids with a vascular network offer great application prospects for drug screening, disease modeling, and therapeutics. However, the application of stem cell-derived organoids is hindered by insufficient vascularization and maturation. Here, we review different theories about the origin of hepatic cells and the morphogenesis of hepatic vessels to provide potential approaches for organoid generation. We also review the main protocols for generating vascularized liver organoids from stem cells and consider their potential and limitations in the generation of vascularized liver organoids. |
format | Online Article Text |
id | pubmed-8301828 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-83018282021-07-24 Engineering the Vasculature of Stem-Cell-Derived Liver Organoids Zhang, Xv Tang, Liling Yi, Qian Biomolecules Review The vasculature of stem-cell-derived liver organoids can be engineered using methods that recapitulate embryonic liver development. Hepatic organoids with a vascular network offer great application prospects for drug screening, disease modeling, and therapeutics. However, the application of stem cell-derived organoids is hindered by insufficient vascularization and maturation. Here, we review different theories about the origin of hepatic cells and the morphogenesis of hepatic vessels to provide potential approaches for organoid generation. We also review the main protocols for generating vascularized liver organoids from stem cells and consider their potential and limitations in the generation of vascularized liver organoids. MDPI 2021-06-30 /pmc/articles/PMC8301828/ /pubmed/34208902 http://dx.doi.org/10.3390/biom11070966 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhang, Xv Tang, Liling Yi, Qian Engineering the Vasculature of Stem-Cell-Derived Liver Organoids |
title | Engineering the Vasculature of Stem-Cell-Derived Liver Organoids |
title_full | Engineering the Vasculature of Stem-Cell-Derived Liver Organoids |
title_fullStr | Engineering the Vasculature of Stem-Cell-Derived Liver Organoids |
title_full_unstemmed | Engineering the Vasculature of Stem-Cell-Derived Liver Organoids |
title_short | Engineering the Vasculature of Stem-Cell-Derived Liver Organoids |
title_sort | engineering the vasculature of stem-cell-derived liver organoids |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301828/ https://www.ncbi.nlm.nih.gov/pubmed/34208902 http://dx.doi.org/10.3390/biom11070966 |
work_keys_str_mv | AT zhangxv engineeringthevasculatureofstemcellderivedliverorganoids AT tangliling engineeringthevasculatureofstemcellderivedliverorganoids AT yiqian engineeringthevasculatureofstemcellderivedliverorganoids |