Cargando…

Bisphenol a Exposure and Kidney Diseases: Systematic Review, Meta-Analysis, and NHANES 03–16 Study

Bisphenol A (BPA) is a compound that is especially widespread in most commonly used objects due to its multiple uses in the plastic industry. However, several data support the need to restrict its use. In recent years, new implications of BPA on the renal system have been discovered, which denotes t...

Descripción completa

Detalles Bibliográficos
Autores principales: Moreno-Gómez-Toledano, Rafael, Arenas, María I., Vélez-Vélez, Esperanza, Coll, Elisabeth, Quiroga, Borja, Bover, Jordi, Bosch, Ricardo J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301850/
https://www.ncbi.nlm.nih.gov/pubmed/34356670
http://dx.doi.org/10.3390/biom11071046
_version_ 1783726766646362112
author Moreno-Gómez-Toledano, Rafael
Arenas, María I.
Vélez-Vélez, Esperanza
Coll, Elisabeth
Quiroga, Borja
Bover, Jordi
Bosch, Ricardo J.
author_facet Moreno-Gómez-Toledano, Rafael
Arenas, María I.
Vélez-Vélez, Esperanza
Coll, Elisabeth
Quiroga, Borja
Bover, Jordi
Bosch, Ricardo J.
author_sort Moreno-Gómez-Toledano, Rafael
collection PubMed
description Bisphenol A (BPA) is a compound that is especially widespread in most commonly used objects due to its multiple uses in the plastic industry. However, several data support the need to restrict its use. In recent years, new implications of BPA on the renal system have been discovered, which denotes the need to expand studies in patients. To this end, a systematic review and a meta-analysis was performed to explore existing literature that examines the BPA-kidney disease paradigm and to determine what and how future studies will need to be carried out. Our systematic review revealed that only few relevant publications have focused on the problem. However, the subsequent meta-analysis revealed that high blood concentrations of BPA could be a factor in developing kidney disease, at least in people with previous pathologies such as diabetes or hypertension. Furthermore, BPA could also represent a risk factor in healthy people whose urinary excretion is higher. Finally, the data analyzed from the NHANES 03-16 cohort provided new evidence on the possible involvement of BPA in kidney disease. Therefore, our results underline the need to carry out a thorough and methodologically homogeneous study, delving into the relationship between urinary and blood BPA, glomerular filtration rate, and urine albumin-to-creatinine ratio, preferably in population groups at risk, and subsequently in the general population, to solve this relevant conundrum with critical potential implications in Public Health.
format Online
Article
Text
id pubmed-8301850
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-83018502021-07-24 Bisphenol a Exposure and Kidney Diseases: Systematic Review, Meta-Analysis, and NHANES 03–16 Study Moreno-Gómez-Toledano, Rafael Arenas, María I. Vélez-Vélez, Esperanza Coll, Elisabeth Quiroga, Borja Bover, Jordi Bosch, Ricardo J. Biomolecules Article Bisphenol A (BPA) is a compound that is especially widespread in most commonly used objects due to its multiple uses in the plastic industry. However, several data support the need to restrict its use. In recent years, new implications of BPA on the renal system have been discovered, which denotes the need to expand studies in patients. To this end, a systematic review and a meta-analysis was performed to explore existing literature that examines the BPA-kidney disease paradigm and to determine what and how future studies will need to be carried out. Our systematic review revealed that only few relevant publications have focused on the problem. However, the subsequent meta-analysis revealed that high blood concentrations of BPA could be a factor in developing kidney disease, at least in people with previous pathologies such as diabetes or hypertension. Furthermore, BPA could also represent a risk factor in healthy people whose urinary excretion is higher. Finally, the data analyzed from the NHANES 03-16 cohort provided new evidence on the possible involvement of BPA in kidney disease. Therefore, our results underline the need to carry out a thorough and methodologically homogeneous study, delving into the relationship between urinary and blood BPA, glomerular filtration rate, and urine albumin-to-creatinine ratio, preferably in population groups at risk, and subsequently in the general population, to solve this relevant conundrum with critical potential implications in Public Health. MDPI 2021-07-16 /pmc/articles/PMC8301850/ /pubmed/34356670 http://dx.doi.org/10.3390/biom11071046 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moreno-Gómez-Toledano, Rafael
Arenas, María I.
Vélez-Vélez, Esperanza
Coll, Elisabeth
Quiroga, Borja
Bover, Jordi
Bosch, Ricardo J.
Bisphenol a Exposure and Kidney Diseases: Systematic Review, Meta-Analysis, and NHANES 03–16 Study
title Bisphenol a Exposure and Kidney Diseases: Systematic Review, Meta-Analysis, and NHANES 03–16 Study
title_full Bisphenol a Exposure and Kidney Diseases: Systematic Review, Meta-Analysis, and NHANES 03–16 Study
title_fullStr Bisphenol a Exposure and Kidney Diseases: Systematic Review, Meta-Analysis, and NHANES 03–16 Study
title_full_unstemmed Bisphenol a Exposure and Kidney Diseases: Systematic Review, Meta-Analysis, and NHANES 03–16 Study
title_short Bisphenol a Exposure and Kidney Diseases: Systematic Review, Meta-Analysis, and NHANES 03–16 Study
title_sort bisphenol a exposure and kidney diseases: systematic review, meta-analysis, and nhanes 03–16 study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301850/
https://www.ncbi.nlm.nih.gov/pubmed/34356670
http://dx.doi.org/10.3390/biom11071046
work_keys_str_mv AT morenogomeztoledanorafael bisphenolaexposureandkidneydiseasessystematicreviewmetaanalysisandnhanes0316study
AT arenasmariai bisphenolaexposureandkidneydiseasessystematicreviewmetaanalysisandnhanes0316study
AT velezvelezesperanza bisphenolaexposureandkidneydiseasessystematicreviewmetaanalysisandnhanes0316study
AT collelisabeth bisphenolaexposureandkidneydiseasessystematicreviewmetaanalysisandnhanes0316study
AT quirogaborja bisphenolaexposureandkidneydiseasessystematicreviewmetaanalysisandnhanes0316study
AT boverjordi bisphenolaexposureandkidneydiseasessystematicreviewmetaanalysisandnhanes0316study
AT boschricardoj bisphenolaexposureandkidneydiseasessystematicreviewmetaanalysisandnhanes0316study