Cargando…

A New Pentafluorothio-Substituted Curcuminoid with Superior Antitumor Activity

A new and readily available pentafluorothiophenyl-substituted N-methyl-piperidone curcuminoid 1a was prepared and investigated for its anti-proliferative, pro-apoptotic and cancer stem cell-differentiating activities against a panel of human tumor cell lines derived from various tumor entities. The...

Descripción completa

Detalles Bibliográficos
Autores principales:	Linder, Benedikt, Köhler, Leonhard H. F., Reisbeck, Lisa, Menger, Dominic, Subramaniam, Dharmalingam, Herold-Mende, Christel, Anant, Shrikant, Schobert, Rainer, Biersack, Bernhard, Kögel, Donat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301868/ https://www.ncbi.nlm.nih.gov/pubmed/34202286 http://dx.doi.org/10.3390/biom11070947

Ejemplares similares

Antitumor Effects of a New Retinoate of the Fungal Cytotoxin Illudin M in Brain Tumor Models
por: Linder, Benedikt, et al.
Publicado: (2022)

Improved Anticancer Activities of a New Pentafluorothio-Substituted Vorinostat-Type Histone Deacetylase Inhibitor
por: Goehringer, Nils, et al.
Publicado: (2021)

A New Synthetic Curcuminoid Displays Antitumor Activities in Metastasized Melanoma
por: Kaps, Leonard, et al.
Publicado: (2023)

CHRDL1 Regulates Stemness in Glioma Stem-like Cells
por: Berglar, Inka, et al.
Publicado: (2022)

Fluorinated and N-Acryloyl-Modified 3,5-Di[(E)-benzylidene]piperidin-4-one Curcuminoids for the Treatment of Pancreatic Carcinoma
por: Ghosh, Hindole, et al.
Publicado: (2023)

STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death
por: Remy, Janina, et al.
Publicado: (2022)

Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases Their Susceptibility to Temozolomide
por: Gerstmeier, Julia, et al.
Publicado: (2021)

Autophagy in Cancer Cell Death
por: Linder, Benedikt, et al.
Publicado: (2019)

2‐Amino‐4‐aryl‐5‐oxo‐4,5‐dihydropyrano[3,2‐c]chromene‐3‐carbonitriles with Microtubule‐Disruptive, Centrosome‐Declustering, and Antiangiogenic Effects in vitro and in vivo
por: Köhler, Leonhard H. F., et al.
Publicado: (2022)

DNA Methyltransferases: A Novel Target for Prevention and Therapy
por: Subramaniam, Dharmalingam, et al.
Publicado: (2014)

Multimodal 4-arylchromene derivatives with microtubule-destabilizing, anti-angiogenic, and MYB-inhibitory activities
por: Köhler, Leonhard H. F., et al.
Publicado: (2023)

3508 Ciclopirox Olamine Demonstrates Inhibitory Effects on Esophageal Tumor Cells
por: Ryan, Randi, et al.
Publicado: (2019)

At the Crossroads of Apoptosis and Autophagy: Multiple Roles of the Co-Chaperone BAG3 in Stress and Therapy Resistance of Cancer
por: Kögel, Donat, et al.
Publicado: (2020)

Structure-Activity Relationships of the Antitumor C(5)-Curcuminoid GO-Y030
por: Kohyama, Aki, et al.
Publicado: (2015)

Molecular Determinants of Calcitriol Signaling and Sensitivity in Glioma Stem-like Cells
por: Rehbein, Sarah, et al.
Publicado: (2023)

Guided Antitumoural Drugs: (Imidazol‐2‐ylidene)(L)gold(I) Complexes Seeking Cellular Targets Controlled by the Nature of Ligand L
por: Bär, Sofia I., et al.
Publicado: (2021)

Natural compounds targeting major cell signaling pathways: a novel paradigm for osteosarcoma therapy
por: Angulo, Pablo, et al.
Publicado: (2017)

Curcuminoid Co-Loading Platinum Heparin-Poloxamer P403 Nanogel Increasing Effectiveness in Antitumor Activity
por: Nguyen, Ngoc The, et al.
Publicado: (2022)

An In Vitro and In Silico Study of Antioxidant Properties of Curcuminoid N-alkylpyridinium Salts: Initial Assessment of Their Antitumoral Properties
por: Forero-Doria, Oscar, et al.
Publicado: (2022)

Curcumin Induces Cell Death in Esophageal Cancer Cells through Modulating Notch Signaling
por: Subramaniam, Dharmalingam, et al.
Publicado: (2012)

Recent advances in the investigation of curcuminoids
por: Itokawa, Hideji, et al.
Publicado: (2008)

Synthesis of curcuminoid-imprinted polymers applied to the solid-phase extraction of curcuminoids from turmeric samples
por: Thongchai, Wisanu, et al.
Publicado: (2018)

Super-enhancers: novel target for pancreatic ductal adenocarcinoma
por: Ghosh, Chandrayee, et al.
Publicado: (2019)

3D cell cultures, as a surrogate for animal models, enhance the diagnostic value of preclinical in vitro investigations by adding information on the tumour microenvironment: a comparative study of new dual-mode HDAC inhibitors
por: Bär, Sofia I., et al.
Publicado: (2022)

Reversed-phase High-performance Liquid Chromatography Method for Analysis of Curcuminoids and Curcuminoid-loaded Liposome Formulation
por: Jangle, R. D., et al.
Publicado: (2013)

Efficacy of Oral Curcuminoid Fraction from Curcuma xanthorrhiza and Curcuminoid Cider in High-cholesterol Fed Rats
por: Mauren, Flavia Maria, et al.
Publicado: (2016)

Bcr-TMP, a Novel Nanomolar-Active Compound That Exhibits Both MYB- and Microtubule-Inhibitory Activity
por: Yusenko, Maria V., et al.
Publicado: (2021)

Arsenic Trioxide and (−)-Gossypol Synergistically Target Glioma Stem-Like Cells via Inhibition of Hedgehog and Notch Signaling
por: Linder, Benedikt, et al.
Publicado: (2019)

Dose escalation of a curcuminoid formulation
por: Lao, Christopher D, et al.
Publicado: (2006)

The antioxidant activity of some curcuminoids and chalcones
por: Sökmen, Münevver, et al.
Publicado: (2016)

Antitumor and antiangiogenic activity of the novel chimeric inhibitor animacroxam in testicular germ cell cancer
por: Steinemann, Gustav, et al.
Publicado: (2019)

Methanolic Extracts of Bitter Melon Inhibit Colon Cancer Stem Cells by Affecting Energy Homeostasis and Autophagy
por: Kwatra, Deep, et al.
Publicado: (2013)

Synthesis of Curcuminoids and Evaluation of Their Cytotoxic and Antioxidant Properties
por: Lozada-García, María Concepción, et al.
Publicado: (2017)

Synthesis and Biological Evaluation of Novel Curcuminoid Derivatives
por: Cao, Ya-Kun, et al.
Publicado: (2014)

Microencapsulation Curcuminoids for Effective Delivery in Pharmaceutical Application
por: Ang, Lee Fung, et al.
Publicado: (2019)

Associating gene expressions with curcuminoid biosynthesis in turmeric
por: Ayer, Dipendra Kumar, et al.
Publicado: (2020)

Improved Synthesis of Asymmetric Curcuminoids and Their Assessment as Antioxidants
por: Cheng, Yang-Je, et al.
Publicado: (2022)

Editorial: Curcuminoids: their pleiotropism against hallmarks of cancers
por: Pouliquen, Daniel L., et al.
Publicado: (2023)

MetaboDiff: an R package for differential metabolomic analysis
por: Mock, Andreas, et al.
Publicado: (2018)

BAG3 Overexpression and Cytoprotective Autophagy Mediate Apoptosis Resistance in Chemoresistant Breast Cancer Cells
por: Das, Chandan Kanta, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_aselbt6u3ho97js8upj9r6b5er