Identification of HSP47 Binding Site on Native Collagen and Its Implications for the Development of HSP47 Inhibitors

HSP47 (heat shock protein 47) is a collagen-specific molecular chaperone that is essential for procollagen folding and function. Previous studies have shown that HSP47 binding requires a critical Arg residue at the Y position of the (Gly-Xaa-Yaa) repeats of collagen; however, the exact binding sites...

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Detalles Bibliográficos
Autores principales: Cai, Haiyan, Sasikumar, Parvathy, Little, Gemma, Bihan, Dominique, Hamaia, Samir W., Zhou, Aiwu, Gibbins, Jonathan M., Farndale, Richard W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301893/
https://www.ncbi.nlm.nih.gov/pubmed/34356607
http://dx.doi.org/10.3390/biom11070983

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