Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology †

Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways which are produced in part from a terpenoid co-substrate. These mixed biosynthetically hybrid compounds are widely produced by bacteria, algae, plants, and animals. Notably amazing chemical diversity is generated amon...

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Detalles Bibliográficos
Autores principales: Nazir, Mamona, Saleem, Muhammad, Tousif, Muhammad Imran, Anwar, Muhammad Aijaz, Surup, Frank, Ali, Iftikhar, Wang, Daijie, Mamadalieva, Nilufar Z., Alshammari, Elham, Ashour, Mohamed L., Ashour, Ahmed M., Ahmed, Ishtiaq, , Elizbit, Green, Ivan R., Hussain, Hidayat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301922/
https://www.ncbi.nlm.nih.gov/pubmed/34209734
http://dx.doi.org/10.3390/biom11070957
Descripción
Sumario:Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways which are produced in part from a terpenoid co-substrate. These mixed biosynthetically hybrid compounds are widely produced by bacteria, algae, plants, and animals. Notably amazing chemical diversity is generated among meroterpenoids via a combination of terpenoid scaffolds with polyketides, alkaloids, phenols, and amino acids. This review deals with the isolation, chemical diversity, and biological effects of 452 new meroterpenoids reported from natural sources from January 2016 to December 2020. Most of the meroterpenoids possess antimicrobial, cytotoxic, antioxidant, anti-inflammatory, antiviral, enzyme inhibitory, and immunosupressive effects.

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