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Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology †
Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways which are produced in part from a terpenoid co-substrate. These mixed biosynthetically hybrid compounds are widely produced by bacteria, algae, plants, and animals. Notably amazing chemical diversity is generated amon...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301922/ https://www.ncbi.nlm.nih.gov/pubmed/34209734 http://dx.doi.org/10.3390/biom11070957 |
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| author | Nazir, Mamona Saleem, Muhammad Tousif, Muhammad Imran Anwar, Muhammad Aijaz Surup, Frank Ali, Iftikhar Wang, Daijie Mamadalieva, Nilufar Z. Alshammari, Elham Ashour, Mohamed L. Ashour, Ahmed M. Ahmed, Ishtiaq , Elizbit Green, Ivan R. Hussain, Hidayat |
| author_facet | Nazir, Mamona Saleem, Muhammad Tousif, Muhammad Imran Anwar, Muhammad Aijaz Surup, Frank Ali, Iftikhar Wang, Daijie Mamadalieva, Nilufar Z. Alshammari, Elham Ashour, Mohamed L. Ashour, Ahmed M. Ahmed, Ishtiaq , Elizbit Green, Ivan R. Hussain, Hidayat |
| author_sort | Nazir, Mamona |
| collection | PubMed |
| description | Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways which are produced in part from a terpenoid co-substrate. These mixed biosynthetically hybrid compounds are widely produced by bacteria, algae, plants, and animals. Notably amazing chemical diversity is generated among meroterpenoids via a combination of terpenoid scaffolds with polyketides, alkaloids, phenols, and amino acids. This review deals with the isolation, chemical diversity, and biological effects of 452 new meroterpenoids reported from natural sources from January 2016 to December 2020. Most of the meroterpenoids possess antimicrobial, cytotoxic, antioxidant, anti-inflammatory, antiviral, enzyme inhibitory, and immunosupressive effects. |
| format | Online Article Text |
| id | pubmed-8301922 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-83019222021-07-24 Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology † Nazir, Mamona Saleem, Muhammad Tousif, Muhammad Imran Anwar, Muhammad Aijaz Surup, Frank Ali, Iftikhar Wang, Daijie Mamadalieva, Nilufar Z. Alshammari, Elham Ashour, Mohamed L. Ashour, Ahmed M. Ahmed, Ishtiaq , Elizbit Green, Ivan R. Hussain, Hidayat Biomolecules Review Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways which are produced in part from a terpenoid co-substrate. These mixed biosynthetically hybrid compounds are widely produced by bacteria, algae, plants, and animals. Notably amazing chemical diversity is generated among meroterpenoids via a combination of terpenoid scaffolds with polyketides, alkaloids, phenols, and amino acids. This review deals with the isolation, chemical diversity, and biological effects of 452 new meroterpenoids reported from natural sources from January 2016 to December 2020. Most of the meroterpenoids possess antimicrobial, cytotoxic, antioxidant, anti-inflammatory, antiviral, enzyme inhibitory, and immunosupressive effects. MDPI 2021-06-29 /pmc/articles/PMC8301922/ /pubmed/34209734 http://dx.doi.org/10.3390/biom11070957 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Review Nazir, Mamona Saleem, Muhammad Tousif, Muhammad Imran Anwar, Muhammad Aijaz Surup, Frank Ali, Iftikhar Wang, Daijie Mamadalieva, Nilufar Z. Alshammari, Elham Ashour, Mohamed L. Ashour, Ahmed M. Ahmed, Ishtiaq , Elizbit Green, Ivan R. Hussain, Hidayat Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology † |
| title | Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology † |
| title_full | Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology † |
| title_fullStr | Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology † |
| title_full_unstemmed | Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology † |
| title_short | Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology † |
| title_sort | meroterpenoids: a comprehensive update insight on structural diversity and biology † |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8301922/ https://www.ncbi.nlm.nih.gov/pubmed/34209734 http://dx.doi.org/10.3390/biom11070957 |
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