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Naïve T Cell Quiescence in Immune Aging

Naïve T cells are critical for protection against emerging viral and bacterial infections. However, the ability of these cells to elicit effective long-term immune responses declines with age and contributes to increased disease susceptibility in older individuals. This decline has been linked with...

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Detalles Bibliográficos
Autor principal: Gustafson, Claire E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302006/
https://www.ncbi.nlm.nih.gov/pubmed/34308428
http://dx.doi.org/10.20900/agmr20210015
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author Gustafson, Claire E.
author_facet Gustafson, Claire E.
author_sort Gustafson, Claire E.
collection PubMed
description Naïve T cells are critical for protection against emerging viral and bacterial infections. However, the ability of these cells to elicit effective long-term immune responses declines with age and contributes to increased disease susceptibility in older individuals. This decline has been linked with the breakdown of cellular quiescence that causes partial differentiation of naïve T cells with age, but the underlying mediators of this breakdown are unclear. Comparisons to stem cell quiescence in mice and man offer insight into naïve T cells and aging. However, the utilization of single cell technologies in combination with advances in the biology of human tissue aging is needed to provide further understanding of naïve T cell complexity and quiescence breakdown with age.
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spelling pubmed-83020062021-07-23 Naïve T Cell Quiescence in Immune Aging Gustafson, Claire E. Adv Geriatr Med Res Article Naïve T cells are critical for protection against emerging viral and bacterial infections. However, the ability of these cells to elicit effective long-term immune responses declines with age and contributes to increased disease susceptibility in older individuals. This decline has been linked with the breakdown of cellular quiescence that causes partial differentiation of naïve T cells with age, but the underlying mediators of this breakdown are unclear. Comparisons to stem cell quiescence in mice and man offer insight into naïve T cells and aging. However, the utilization of single cell technologies in combination with advances in the biology of human tissue aging is needed to provide further understanding of naïve T cell complexity and quiescence breakdown with age. 2021-06-26 2021 /pmc/articles/PMC8302006/ /pubmed/34308428 http://dx.doi.org/10.20900/agmr20210015 Text en https://creativecommons.org/licenses/by/4.0/Licensee Hapres, London, United Kingdom. This is an open access article distributed under the terms and conditions of Creative Commons Attribution 4.0 International License.
spellingShingle Article
Gustafson, Claire E.
Naïve T Cell Quiescence in Immune Aging
title Naïve T Cell Quiescence in Immune Aging
title_full Naïve T Cell Quiescence in Immune Aging
title_fullStr Naïve T Cell Quiescence in Immune Aging
title_full_unstemmed Naïve T Cell Quiescence in Immune Aging
title_short Naïve T Cell Quiescence in Immune Aging
title_sort naïve t cell quiescence in immune aging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302006/
https://www.ncbi.nlm.nih.gov/pubmed/34308428
http://dx.doi.org/10.20900/agmr20210015
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