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Naïve T Cell Quiescence in Immune Aging
Naïve T cells are critical for protection against emerging viral and bacterial infections. However, the ability of these cells to elicit effective long-term immune responses declines with age and contributes to increased disease susceptibility in older individuals. This decline has been linked with...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302006/ https://www.ncbi.nlm.nih.gov/pubmed/34308428 http://dx.doi.org/10.20900/agmr20210015 |
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author | Gustafson, Claire E. |
author_facet | Gustafson, Claire E. |
author_sort | Gustafson, Claire E. |
collection | PubMed |
description | Naïve T cells are critical for protection against emerging viral and bacterial infections. However, the ability of these cells to elicit effective long-term immune responses declines with age and contributes to increased disease susceptibility in older individuals. This decline has been linked with the breakdown of cellular quiescence that causes partial differentiation of naïve T cells with age, but the underlying mediators of this breakdown are unclear. Comparisons to stem cell quiescence in mice and man offer insight into naïve T cells and aging. However, the utilization of single cell technologies in combination with advances in the biology of human tissue aging is needed to provide further understanding of naïve T cell complexity and quiescence breakdown with age. |
format | Online Article Text |
id | pubmed-8302006 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
record_format | MEDLINE/PubMed |
spelling | pubmed-83020062021-07-23 Naïve T Cell Quiescence in Immune Aging Gustafson, Claire E. Adv Geriatr Med Res Article Naïve T cells are critical for protection against emerging viral and bacterial infections. However, the ability of these cells to elicit effective long-term immune responses declines with age and contributes to increased disease susceptibility in older individuals. This decline has been linked with the breakdown of cellular quiescence that causes partial differentiation of naïve T cells with age, but the underlying mediators of this breakdown are unclear. Comparisons to stem cell quiescence in mice and man offer insight into naïve T cells and aging. However, the utilization of single cell technologies in combination with advances in the biology of human tissue aging is needed to provide further understanding of naïve T cell complexity and quiescence breakdown with age. 2021-06-26 2021 /pmc/articles/PMC8302006/ /pubmed/34308428 http://dx.doi.org/10.20900/agmr20210015 Text en https://creativecommons.org/licenses/by/4.0/Licensee Hapres, London, United Kingdom. This is an open access article distributed under the terms and conditions of Creative Commons Attribution 4.0 International License. |
spellingShingle | Article Gustafson, Claire E. Naïve T Cell Quiescence in Immune Aging |
title | Naïve T Cell Quiescence in Immune Aging |
title_full | Naïve T Cell Quiescence in Immune Aging |
title_fullStr | Naïve T Cell Quiescence in Immune Aging |
title_full_unstemmed | Naïve T Cell Quiescence in Immune Aging |
title_short | Naïve T Cell Quiescence in Immune Aging |
title_sort | naïve t cell quiescence in immune aging |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302006/ https://www.ncbi.nlm.nih.gov/pubmed/34308428 http://dx.doi.org/10.20900/agmr20210015 |
work_keys_str_mv | AT gustafsonclairee naivetcellquiescenceinimmuneaging |