Acute Tubular Injury in a Patient on a Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor

A 72-year-old man with coronary artery disease, statin intolerance, and chronic kidney disease stage IIIa was initiated on alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, and developed acute kidney injury. A kidney biopsy was performed and suggested acute tubular injury. The s...

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Autores principales: Pickett, June K., Shah, Maulin, Gillette, Michael, Jones, Peter, Virani, Salim, Ballantyne, Christie, Nambi, Vijay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302111/
https://www.ncbi.nlm.nih.gov/pubmed/34317411
http://dx.doi.org/10.1016/j.jaccas.2020.04.039
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author Pickett, June K.
Shah, Maulin
Gillette, Michael
Jones, Peter
Virani, Salim
Ballantyne, Christie
Nambi, Vijay
author_facet Pickett, June K.
Shah, Maulin
Gillette, Michael
Jones, Peter
Virani, Salim
Ballantyne, Christie
Nambi, Vijay
author_sort Pickett, June K.
collection PubMed
description A 72-year-old man with coronary artery disease, statin intolerance, and chronic kidney disease stage IIIa was initiated on alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, and developed acute kidney injury. A kidney biopsy was performed and suggested acute tubular injury. The serum creatinine returned to baseline after discontinuation of alirocumab. (Level of Difficulty: Intermediate.)
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spelling pubmed-83021112021-07-26 Acute Tubular Injury in a Patient on a Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor Pickett, June K. Shah, Maulin Gillette, Michael Jones, Peter Virani, Salim Ballantyne, Christie Nambi, Vijay JACC Case Rep Case Report A 72-year-old man with coronary artery disease, statin intolerance, and chronic kidney disease stage IIIa was initiated on alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, and developed acute kidney injury. A kidney biopsy was performed and suggested acute tubular injury. The serum creatinine returned to baseline after discontinuation of alirocumab. (Level of Difficulty: Intermediate.) Elsevier 2020-06-17 /pmc/articles/PMC8302111/ /pubmed/34317411 http://dx.doi.org/10.1016/j.jaccas.2020.04.039 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Pickett, June K.
Shah, Maulin
Gillette, Michael
Jones, Peter
Virani, Salim
Ballantyne, Christie
Nambi, Vijay
Acute Tubular Injury in a Patient on a Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor
title Acute Tubular Injury in a Patient on a Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor
title_full Acute Tubular Injury in a Patient on a Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor
title_fullStr Acute Tubular Injury in a Patient on a Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor
title_full_unstemmed Acute Tubular Injury in a Patient on a Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor
title_short Acute Tubular Injury in a Patient on a Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitor
title_sort acute tubular injury in a patient on a proprotein convertase subtilisin/kexin type 9 inhibitor
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302111/
https://www.ncbi.nlm.nih.gov/pubmed/34317411
http://dx.doi.org/10.1016/j.jaccas.2020.04.039
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