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A molecular sensor for cholesterol in the human serotonin(1A) receptor

The function of several G protein–coupled receptors (GPCRs) exhibits cholesterol sensitivity. Cholesterol sensitivity of GPCRs could be attributed to specific sequence and structural features, such as the cholesterol recognition/interaction amino acid consensus (CRAC) motif, that facilitate their ch...

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Detalles Bibliográficos
Autores principales: Kumar, G. Aditya, Sarkar, Parijat, Stepniewski, Tomasz Maciej, Jafurulla, Md., Singh, Shishu Pal, Selent, Jana, Chattopadhyay, Amitabha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302130/
https://www.ncbi.nlm.nih.gov/pubmed/34301606
http://dx.doi.org/10.1126/sciadv.abh2922