Cargando…

Data‐driven personalization of a physiologically based pharmacokinetic model for caffeine: A systematic assessment

Physiologically based pharmacokinetic (PBPK) models have been proposed as a tool for more accurate individual pharmacokinetic (PK) predictions and model‐informed precision dosing, but their application in clinical practice is still rare. This study systematically assesses the benefit of using indivi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fendt, Rebekka, Hofmann, Ute, Schneider, Annika R. P., Schaeffeler, Elke, Burghaus, Rolf, Yilmaz, Ali, Blank, Lars Mathias, Kerb, Reinhold, Lippert, Jörg, Schlender, Jan‐Frederik, Schwab, Matthias, Kuepfer, Lars
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302243/ https://www.ncbi.nlm.nih.gov/pubmed/34053199 http://dx.doi.org/10.1002/psp4.12646

Ejemplares similares

Translational learning from clinical studies predicts drug pharmacokinetics across patient populations
por: Krauss, Markus, et al.
Publicado: (2017)

Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice
por: Fendt, Rebekka, et al.
Publicado: (2023)

Prediction of Drug–Drug–Gene Interaction Scenarios of (E)-Clomiphene and Its Metabolites Using Physiologically Based Pharmacokinetic Modeling
por: Kovar, Christina, et al.
Publicado: (2022)

Predictive Performance of Physiology‐Based Pharmacokinetic Dose Estimates for Pediatric Trials: Evaluation With 10 Bayer Small‐Molecule Compounds in Children
por: Ince, Ibrahim, et al.
Publicado: (2021)

Using Bayesian-PBPK modeling for assessment of inter-individual variability and subgroup stratification
por: Krauss, Markus, et al.
Publicado: (2013)

Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other membrane transporters
por: Matthaei, Johannes, et al.
Publicado: (2016)

Evaluation of the Efficacy and Safety of Rivaroxaban Using a Computer Model for Blood Coagulation
por: Burghaus, Rolf, et al.
Publicado: (2011)

A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim
por: Niederalt, Christoph, et al.
Publicado: (2017)

Integrating Cellular Metabolism into a Multiscale Whole-Body Model
por: Krauss, Markus, et al.
Publicado: (2012)

Physiologically Based Pharmacokinetic Modeling to Describe the CYP2D6 Activity Score-Dependent Metabolism of Paroxetine, Atomoxetine and Risperidone
por: Rüdesheim, Simeon, et al.
Publicado: (2022)

A Physiologically Based Pharmacokinetic Model of Isoniazid and Its Application in Individualizing Tuberculosis Chemotherapy
por: Cordes, Henrik, et al.
Publicado: (2016)

Proton Pump Inhibitors Inhibit Metformin Uptake by Organic Cation Transporters (OCTs)
por: Nies, Anne T., et al.
Publicado: (2011)

Development of a Paediatric Population-Based Model of the Pharmacokinetics of Rivaroxaban
por: Willmann, Stefan, et al.
Publicado: (2013)

Pharmacokinetics of rivaroxaban in children using physiologically based and population pharmacokinetic modelling: an EINSTEIN-Jr phase I study
por: Willmann, Stefan, et al.
Publicado: (2018)

Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen‐induced toxicity in humans
por: Thiel, C, et al.
Publicado: (2017)

Clinical Translation in the Virtual Liver Network
por: Kuepfer, L, et al.
Publicado: (2014)

A generic framework for the physiologically‐based pharmacokinetic platform qualification of PK‐Sim and its application to predicting cytochrome P450 3A4–mediated drug–drug interactions
por: Frechen, Sebastian, et al.
Publicado: (2021)

Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model
por: Kuepfer, L, et al.
Publicado: (2016)

Large-scale (13)C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast
por: Blank, Lars M, et al.
Publicado: (2005)

Development of a Physiologically Based Computational Kidney Model to Describe the Renal Excretion of Hydrophilic Agents in Rats
por: Niederalt, Christoph, et al.
Publicado: (2013)

Pharmacogenomics: a key component of personalized therapy
por: Schwab, Matthias, et al.
Publicado: (2012)

Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients
por: Thiel, Christoph, et al.
Publicado: (2016)

Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situations
por: Thiel, Christoph, et al.
Publicado: (2018)

Data-driven identification of heart failure disease states and progression pathways using electronic health records
por: Nagamine, Tasha, et al.
Publicado: (2022)

Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals
por: Schlender, Jan-Frederik, et al.
Publicado: (2016)

Representative Sinusoids for Hepatic Four-Scale Pharmacokinetics Simulations
por: Schwen, Lars Ole, et al.
Publicado: (2015)

Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy
por: Fisel, Pascale, et al.
Publicado: (2018)

A Physiologically-Based Pharmacokinetic Model to Describe Ciprofloxacin Pharmacokinetics Over the Entire Span of Life
por: Schlender, Jan-Frederik, et al.
Publicado: (2018)

Integration of genome-scale metabolic networks into whole-body PBPK models shows phenotype-specific cases of drug-induced metabolic perturbation
por: Cordes, Henrik, et al.
Publicado: (2018)

Pharmacokinetic Interaction of Chrysin with Caffeine in Rats
por: Noh, Keumhan, et al.
Publicado: (2016)

Inherited and Acquired Determinants of Hepatic CYP3A Activity in Humans
por: Matthaei, Johannes, et al.
Publicado: (2020)

CKD subpopulations defined by risk‐factors: A longitudinal analysis of electronic health records
por: Ramaswamy, Rajagopalan, et al.
Publicado: (2021)

Bayesian Population Physiologically-Based Pharmacokinetic (PBPK) Approach for a Physiologically Realistic Characterization of Interindividual Variability in Clinically Relevant Populations
por: Krauss, Markus, et al.
Publicado: (2015)

Effects of Baicalin on Oral Pharmacokinetics of Caffeine in Rats
por: Noh, Keumhan, et al.
Publicado: (2015)

Time effect of rutaecarpine on caffeine pharmacokinetics in rats
por: Estari, Rohit Kumar, et al.
Publicado: (2021)

A Comparative Analysis of Drug-Induced Hepatotoxicity in Clinically Relevant Situations
por: Thiel, Christoph, et al.
Publicado: (2017)

DNA methylation is associated with downregulation of the organic cation transporter OCT1 (SLC22A1) in human hepatocellular carcinoma
por: Schaeffeler, Elke, et al.
Publicado: (2011)

Multiscale classification of heart failure phenotypes by unsupervised clustering of unstructured electronic medical record data
por: Nagamine, Tasha, et al.
Publicado: (2020)

Myocardial extracellular volume fraction (ECV) measurements based on T1-mapping in healthy monozygotic twins - another similarity or rather disagreement in twins?
por: Florian, Anca R, et al.
Publicado: (2015)

The Impact of CYP3A4*22 on Tacrolimus Pharmacokinetics and Outcome in Clinical Practice at a Single Kidney Transplant Center
por: Abdel-Kahaar, Emaad, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_jn9s97ma9khn9onbl222udlmr9