Beyond the single average tumor: Understanding IO combinations using a clinical QSP model that incorporates heterogeneity in patient response

A quantitative systems pharmacology model for metastatic melanoma was developed for immuno‐oncology with the goal of predicting efficacy of combination checkpoint therapy with pembrolizumab and ipilimumab. This literature‐based model is developed at multiple scales: (i) tumor and immune cell interac...

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Detalles Bibliográficos
Autores principales: Kumar, Rukmini, Thiagarajan, Kannan, Jagannathan, Lakshmanan, Liu, Liming, Mayawala, Kapil, de Alwis, Dinesh, Topp, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302246/
https://www.ncbi.nlm.nih.gov/pubmed/33938166
http://dx.doi.org/10.1002/psp4.12637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302246/
https://www.ncbi.nlm.nih.gov/pubmed/33938166
http://dx.doi.org/10.1002/psp4.12637

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