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Beyond the single average tumor: Understanding IO combinations using a clinical QSP model that incorporates heterogeneity in patient response
A quantitative systems pharmacology model for metastatic melanoma was developed for immuno‐oncology with the goal of predicting efficacy of combination checkpoint therapy with pembrolizumab and ipilimumab. This literature‐based model is developed at multiple scales: (i) tumor and immune cell interac...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8302246/ https://www.ncbi.nlm.nih.gov/pubmed/33938166 http://dx.doi.org/10.1002/psp4.12637 |